Person:
ÖZER, ÖMER FARUK

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ÖMER FARUK
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Now showing 1 - 7 of 7
  • PublicationMetadata only
    Investigation of Oxidative Stress Markers in the Pathogenesis of the Lung, Breast and Colon Cancer
    (2017-09-23T00:00:00Z) ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHBETTİN; ÇOBAN, GANİME; TÜRK, HACI MEHMET; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİN; ÇOBAN, GANİME; TÜRK, HACI MEHMET
  • PublicationOpen Access
    Paraoxonase-1 Phenotype and Its Relationship with Mean Platelet Volume and Oxidative Stress in Coronary Artery Disease
    (2015-09-01) SELEK, ŞAHBETTİN ; ÖZER, ÖMER FARUK ; GOKTEKİN, Omer ; KOÇYİĞİT, ABDÜRRAHİM; KALINBACOGLU, Ceren; ISLEK, Irem ; ISLEK, Tuğba; ARPACI, Beyza; Erol, Neval; MEYDAN, Sedat; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; MEYDAN, SEDAT; GÜLER, ERAY METİN
    Objective: Paraoxonase-1 (PON1) 192 QR polymorphism is believed to be an important protective factor for coronary artery disease (CAD); oxidative stress plays a key role in the development of atherosclerotic CAD. Mean platelet volume (MPV) is also central to the processes, including pathophysiology of CAD and endothelial dysfunction. Thus, we aimed to determine the PON1 phenotype, MPV, and oxidative stress parameters in patients with angiographically proven CAD and to compare them with those in healthy subjects. Methods: Fifty-five CAD patients were diagnosed according to the angiography results, and 37 healthy subjects were present in this study. Serum paraoxonase and arylesterase activities were spectrophotometrically measured. Phenotype distribution was evaluated by the salt-stimulated paraoxonase activity according to arylesterase activity. Oxidative stress markers were evaluated by measuring serum total oxidant status (TOS) and total antioxidant status (TAS) as well as oxidative stress index. Results: In this study, the ratio of salt-stimulated paraoxonase/ OSI levels (S-PON1/OSI) were lower in the CAD patients and the differences were statistically significant (p<0.05). Therefore, the ratio of salt-stimulated paraoxonase/MPV (S -PON1/MPV) and S- PON1/OSI level were significantly different in the CAD patients as compared with controls group (p<0.01). Conclusion: Our study has suggested that S-PON1/OSI and SPON1/ MPV may play a significant role in CAD. To the best of our knowledge, the present study is the first to study the relationship among PON1 phenotype, MPV, and OSI in CAD patients. Thus, lowering of the oxidative stress and the regulation of MPV strategies may be a promising approach for the treatment of CAD.
  • PublicationMetadata only
    Raftlin, presepsin levels and thiol-disulfide homeostasis in acute appendicitis: A pilot study
    (2018-11-01) KOÇYİĞİT, ABDÜRRAHİM; ERSOY, YELİZ EMİNE; SELEK, ŞAHBETTİN; SÜMBÜL, BİLGE; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; MERAL, İSMAİL; YİĞİT, MEHMET; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; MERAL, İSMAİL; SÜMBÜL, BİLGE; SELEK, ŞAHABETTİN; ERSOY, YELIZ EMINE
    Objective: To investigate some of the new inflammatory and oxidative stress markers in acute appendicitis.
  • PublicationMetadata only
    Protective effect of beta-glucan on renal ischemia and reperfusion injury in young and aged rats.
    (2014-09-12) EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; AYDIN, M. S.; IRAZ, M.; SELEK, ŞAHBETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; SELEK, ŞAHABETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM
  • PublicationMetadata only
    Raftlin, Presepsin Levels and ThioDisulfide Homeostasis in Acute Appendicitis
    (2017-09-23) ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; GÜLTEPE, BİLGE; YİĞİT, MEHMET; ERSOY, YELİZ EMİNE; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİN; SÜMBÜL, BİLGE; ERSOY, YELIZ EMINE
  • PublicationMetadata only
    Akciğer, meme ve kolon kanserli hastalarda oksidatif stres parametrelerinin değişimi
    (2019-01-01) ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; SELEK, ŞAHBETTİN; ÇOBAN, GANİME; KOÇYİĞİT, ABDÜRRAHİM; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; ÇOBAN, GANİME; KOÇYİĞİT, ABDÜRRAHİM
  • PublicationOpen Access
    Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor
    (2016-10-13) Kılıç, Elif; Ozer, Omer Faruk; Erek, Aybala Toprak; ERMAN, HAYRİYE; Torun, EMEL; AYHAN, Siddika Kesgin; Caglar, HİFA GÜLRU; Selek, Sahbettin; Kocyigit, ABDÜRRAHİM; ÖZER, ÖMER FARUK; TORUN, EMEL; ÇAĞLAR, HİFA GÜLRU; SELEK, ŞAHABETTİN; KOÇYİĞİT, ABDÜRRAHİM
    Background: Childhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association between childhood obesity and inflammatory and oxidative status. Material/Methods: Thirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS) levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test. Results: Body mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism, insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS (med: 2.5 µmol Trolox eq/L (1.7–3.3)) and TOS (med: 49.1 µmol H2 O2 eq/L (34.5–78.8)) levels and TTL (med: 0.22 mmol/L (0.16–0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=–0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=–0.347). Conclusions: In conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complications