Person:
KUŞMAN, TUBA

Profile Picture
Status
Kurumdan Ayrılmıştır
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
TUBA
Last Name
KUŞMAN
Name
Email Address
Birth Date

Filters

2013 - 20142
Reset filters

Settings

Has files: true ×

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    PublicationOpen Access
    Terpenoids, essential oil composition and fatty acids profile, and biological activities of Anatolian Salvia fruticosa Mill.
    (2013-01-01) Topcu, GÜLAÇTI; Ozturk, Mehmet; Kusman, TUBA; BARLA DEMIRKOZ, Ayse Asli; Kolak, Ufuk; Ulubelen, Ayhan; TOPÇU, GÜLAÇTI; KUŞMAN, TUBA
    The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., afforded 7 diterpenoids (carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool), 4 triterpenoids (alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol), a steroid (3-acetylsitosterol), and a flavone (salvigenin). The galls (apples) of the collected plant were separately extracted with hexane to afford fatty acids composed mainly of oleic acid (29%), palmitoleic acid (29%), and stearic acid (23.20%), which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory activity, consisting of mainly 1,8-cineol (58.89%). The antioxidant activity according to 6 complementary tests and anticholinesterase potential of the methanol extracts and triterpenoids alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and sitosterol acetate were also investigated, and methanol extract exhibited the highest antioxidant and anticholinesterase activity, surpassing the other tested extracts and pure compounds.
  • Thumbnail Image
    PublicationOpen Access
    Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer’s Disease
    (2014-02-01) TOPÇU, GÜLAÇTI; KUŞMAN, TUBA; TOPÇU, GÜLAÇTI; KUŞMAN, TUBA
    Alzheimer’s disease (AD) is one of the most common and progressive neurodegenerative disorders with dementia in the world. The precise causes of AD are not fully understood yet, although several important features of its pathophysiology are well described. Current AD treatment is symptomatic and is mainly, but not exclusively, focused on the inhibition of cholinesterases (ChEs). There are four cholinesterase inhibitors approved by the U.S. Food and Drug Administration (FDA): tacrine, donepezil, rivastigmine, and galantamine. Among them, galantamine is a natural drug, and rivastigmine is a derivative of the natural drug physostigmine. In addition, only an NMDA (N-methyl- D-aspartate) receptor antagonist, memantine, is also approved by the FDA in the treatment of patients with moderate to severe AD. However, none of them provides a satisfactory treatment for Alzheimer’s disease, and studies are still going on to find new potential drugs from both synthetic chemicals and natural sources. In this review, studies on the discovery of new cholinesterase inhibitors from natural sources, particularly from Lamiaceae family plants were evaluated, and a number of terpenoids and phenolics/flavonoids isolated are presented as potential drugs in the treatment of Alzheimer’s disease.