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GEPDİREMEN, ALİ AKÇAHAN

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ALİ AKÇAHAN
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GEPDİREMEN
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  • PublicationMetadata only
    Effect of Breast Milk Calcium and Fluidity on Breast Cancer Cells: An In Vitro Cell Culture Study
    (2016-11-01T00:00:00Z) Bayram, Recep; Yavuz, Muhsine Zeynep; Benek, Bedri Selim; BOZKURT, Aysenur Aydogar; UCBEK, Ali; Ozunal, Zeynep Gunes; Gepdiremen, ALİ AKÇAHAN; GEPDİREMEN, ALİ AKÇAHAN
    Aim: The aims of this study were to investigate the effects of calcium at the same concentration as that found in human milk on the viability, proliferation, and adhesion of MCF-7 human breast ductal carcinoma cells by exposing them to calcium at the same frequency as in breastfeeding.
  • PublicationMetadata only
    Possible Cytoprotective Potential of Ruthenium Red in Evaluation of the Rapid Apoptotic Model Induced by H2O2
    (2011-04-01T00:00:00Z) Bayram, Recep; Yavuz, Muhsine Zeynep; Duzenli, Selma; Gepdiremen, ALİ AKÇAHAN; GEPDİREMEN, ALİ AKÇAHAN
    In the present paper, hydrogen peroxide (H2O2) induced an apoptotic process in 1 h and over the doses of 10 mM, while cisplatin did not, in cortical neuronal homogenates of rats. It was proved in DNA fragmentation, MTT and WST-1 assays. Especially, according to WST-1 assay results, apoptotic effect was decided to be very obvious in all tests in the doses of 20 mM of the rapid model of apoptosis of H2O2. Ruthenium red, as a mitochondrial Ca2+ modulator, was tested alone and co-application with H2O2. Without H2O2, at low doses of it, ruthenium red seems to have a slight viability inducing effect in respect to controls in MTT and WST-1, despite that this effect was not observed clearly in DNA fragmentation test. Another point is that the highest dose of ruthenium red (10 M), induces apoptosis, even stronger than the 20 mM H2O2, controversy to the general believing.
  • PublicationMetadata only
    Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line
    (2014-01-01T00:00:00Z) Kaya, Ertugrul; Bayram, Recep; Yaykasli, Kursat Oguz; YILMAZ, Ismail; Bayram, Sait; Yaykasli, Emine; Yavuz, Muhsine Zeynep; Gepdiremen, ALİ AKÇAHAN; GEPDİREMEN, ALİ AKÇAHAN
    Background/aim: Alpha- and beta-amanitins are the main toxins of the poisonous Amanita phalloides mushroom. Although there are many studies available concerning alpha-amanitin, there are limited data about beta-amanitin in the literature. Therefore, this study is aimed at comparing the toxic effects of alpha- and beta-amanitin on the MCF-7 cell line.
  • PublicationMetadata only
    The evaluation and comparison of the alpha and beta amanitin toxicity on MCF-7 cell line
    (2013-07-01T00:00:00Z) Kaya, Ertugrul; Bayram, Recep; Yaykasli, Kursat Oguz; YILMAZ, Ismail; Bayram, Sait; Yaykasli, Emine; Yavuz, Muhsine Zeynep; Gepdiremen, ALİ AKÇAHAN; GEPDİREMEN, ALİ AKÇAHAN
  • PublicationMetadata only
    Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities
    (2014-01-01T00:00:00Z) Durust, Yasar; Karakus, Hamza; Yavuz, Muhsine Zeynep; Gepdiremen, ALİ AKÇAHAN; GEPDİREMEN, ALİ AKÇAHAN
    1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul-fonyl)- 4,5-dihydro-1 H -1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3] triazole-4,6(3 a H, 5 H)-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR (1 H, 1 3 C, 2D), mass spectra, and physical characteristics (mp and R f values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.