Person: İZZETTİN, FIKRET VEHBI
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Publication Metadata only Determination of CYP2C19 polymorphisms, adverse drug reaction, and medication adherence in patients utilized selective serotonin reuptake inhibitors(2015-02-01T00:00:00Z) Deniz, Semanur; SANCAR, MESUT; OKUYAN, BETÜL; ATA, PINAR; Bingol-Ozakpinar, Ozlem; TALAS, Anil; GUNES, Tufan; CALISKAN, Mecit; Izzettin, Fikret Vehbi; İZZETTİN, FIKRET VEHBIPublication Metadata only Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats(2017-09-01T00:00:00Z) Bami, Erliasa; Ozakpinar, Ozlem Bingol; Ozdemir-Kumral, Zarife Nigar; Koroglu, Kutay; ERCAN, FERİHA; CIRAKLI, Zeynep; ŞEKERLER, TURGUT; Izzettin, FİKRET VEHBİ; SANCAR, MESUT; OKUYAN, BETÜL; İZZETTİN, FIKRET VEHBIThis study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.Publication Metadata only The role of the clinical pharmacist in patient education and monıtoring of patients under warfarin treatment(2019-01-01) İZZETTİN, FİKRET VEHBİ; SANCAR, MESUT; AKSOY, NİLAY; TEZCAN, SONGÜL; BEKTAY, MUHAMMED YUNUS; İZZETTİN, FIKRET VEHBI; BEKTAY, MUHAMMED YUNUSThis study was carried out on patients who were under anticoagulation treatment with warfarin, at the outpatient cardiology clinic. The aim was to determine the effectiveness of pharmacist consultation, education, and intervention on each patient-s therapeutic results. A cross-sectional randomized trial has been done. Twenty-five patients were included in the study. The Oral Anticoagulation Knowledge (OAK) Test, Short Form-36 (SF-36) and Duke Anticoagulation Satisfaction Scale (DASS) were applied. Patients resumed their routine anticoagulation treatment and INR and complications were recorded during the study. Additionally, patients received patient education, consultation on lifestyle and anticoagulant usage issues from a pharmacist. The same tests were applied again to the patients on the 90th day of the study and the results were compared with the initial test. Maintenance of INR within the target range and complication rates were compared before and after the intervention. Pre-test and post-test results of the patients revealed statistically significant improvements on the physical and mental score components of the SF-36 (p = 0.001; p = 0.001), OAK test scores (p <= 0.001) and the (negative) -limitations- and -burdens- and -positive effects- components of the DASS (p = 0.005; p < 0.001; p = 0.001). The successful maintenance of INR within target range was significantly higher (p = 0.027). The positive effects of pharmacist consultation and education on therapeutic results were demonstrated.Publication Metadata only Influence of Pharmacist Recommendations for Chemotherapy-Related Problems in Diabetic Cancer Patients(2017-01-01T00:00:00Z) Izzettin, Fikret V.; Al-taie, Anmar; SANCAR, MESUT; ALIUSTAOGLU, Mehmet; İZZETTİN, FIKRET VEHBIDrug related-problems pose additional worse outcomes in cancer patients treated with chemotherapy. A vital role of the clinical pharmacist is the detection and prevention of drug-related problems. The provision of patient education is an important step to reduce and prevent drug-related problems during chemotherapy administration. The objective of this study was to assess the occurrence of drug-related problems and the importance of effective provision of patient education and appropriate recommendations by the clinical pharmacist in reducing and solving of these problems in diabetic patients suffering from cancer.Publication Open Access Determination of Potential Drug-Drug Interactions Using Various Software Programs in a Community Pharmacy Setting(2019-03-01T00:00:00Z) SANCAR, MESUT; Kasik, Aksa; OKUYAN, BETÜL; Batuhan, Sevda; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIObjectives: The aim of the present study was to compare various software programs in detecting potential drug-drug interactions in a community pharmacy setting. Materials and methods: Details of prescriptions were collected from 50 community pharmacies located in İstanbul in March and April 2015 (two days per week). From each pharmacy, the first 20 prescriptions that included more than one drug were collected to evaluate potential drug-drug interactions. The following software programs were utilized to detect potential drug-drug interactions: micromedexsolutions.com, medscape.com, and drugs.com. The number of potential interactions detected by the software programs was determined. Results: At least one potential drug-drug interaction was detected in 39.2% of the 1000 prescriptions by one of the software programs. According to the rates of total drug-drug interactions gathered from various software programs, these programs gave the following results: medscape.com 33.3%, drugs.com 31.3%, and micromedexsolutions.com 21.2%. Conclusion: After comparing different software programs, the potential drug-drug interactions found by the programs proved to be different. Therefore, we recommend that pharmacists confirm with a different program before making a decision when they detect clinically significant potential drug-drug interactions.Publication Metadata only Importance of medication dose adjustment in hospitalized patients with impaired renal function at internal medicine ward: the possible impact of clinical pharmacist(2018-02-01T00:00:00Z) Altan, Aysenur; Ozkan, Oznur; DEMIRTUNC, Refik; OKUYAN, BETÜL; Izzettin, Fikret Vehbi; SANCAR, MESUT; İZZETTİN, FIKRET VEHBIPublication Metadata only Evaluation of drug burden index and medication utilization in geriatric patients at community pharmacy(2015-02-01T00:00:00Z) SANCAR, MESUT; Girgin, Irem; Selcuk, Aysu; Yang, Seonkyeong; Izzettin, Fikret Vehbi; OKUYAN, BETÜL; İZZETTİN, FIKRET VEHBIPublication Metadata only Comparison of conditioning regimen toxicities among autologous stem cell transplantation eligible multiple myeloma patients: High-dose melphalan versus high-dose melphalan and bortezomib(2018-06-01T00:00:00Z) Aypar, Eda; Izzettin, FİKRET VEHBİ; Aki, Sahika Zeynep; SANCAR, MESUT; Yegin, Zeynep Arzu; Turkoz-Sucak, Gulsan; İZZETTİN, FIKRET VEHBIBackground Autologous hematopoietic stem cell transplantation (AHSCT) remains the standard of care for younger patients with multiple myeloma (MM). Currently, high-dose melphalan (HDM) is recommended as conditioning regimen before AHSCT. Preclinical data suggest that combining bortezomib and melphalan has synergistic effect against multiple myeloma cells. Bortezomib and HDM (Bor-HDM) combination as conditioning regimen has been investigated by many other investigators.Publication Metadata only Validation of the Turkish version of medication regimen complexity index among elderly patients(2016-10-01T00:00:00Z) OKUYAN, BETÜL; Babi, Bedis; SANCAR, MESUT; Ay, Pinar; YUCEL, Emre; YUCEL, Aylin; Izzettin, Fikret Vehbi; İZZETTİN, FIKRET VEHBIObjectiveThe aim of this study was to validate the Turkish version of the Medication Regimen Complexity Index- (MRCI).Publication Metadata only The assessment of self-medication utilization in pain management at a community pharmacy setting(2013-05-01T00:00:00Z) OKUYAN, BETÜL; Atalay, Mustafa Vakkas; Sahin, Ceren; Sahin, Duygucan; Izzettin, Fikret V.; SANCAR, MESUT; İZZETTİN, FIKRET VEHBI