Person: İZZETTİN, FIKRET VEHBI
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Publication Metadata only Assessment of pharmacy technicians- attitudes and responsibilities toward patient oriented pharmacy practices at community pharmacy(2012-02-01T00:00:00Z) SANCAR, MERT; OKUYAN, BETÜL; Tamyuksel, E.; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIPublication Metadata only Assessment of attitude and knowledge in patients utilized disposable insulin pens at community pharmacy setting(2016-04-01T00:00:00Z) OKUYAN, BETÜL; Semerci, Z.; Odabasi, G.; Izzettin, FİKRET VEHBİ; SANCAR, MERT; İZZETTİN, FIKRET VEHBIPublication Metadata only Assessment of individuals- knowledge and attitudes towards utilization of analgesics at community pharmacy setting(2019-02-01T00:00:00Z) Torun, B.; ÖZKAN, ONUR CAN; Zortul, H.; Kesedar, S.; Izzettin, FİKRET VEHBİ; SANCAR, MERT; OKUYAN, BETÜL; İZZETTİN, FIKRET VEHBIPublication Metadata only Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats(2017-09-01T00:00:00Z) Bami, Erliasa; Ozakpinar, Ozlem Bingol; Ozdemir-Kumral, Zarife Nigar; Koroglu, Kutay; ERCAN, FERİHA; CIRAKLI, Zeynep; ŞEKERLER, TURGUT; Izzettin, FİKRET VEHBİ; SANCAR, MESUT; OKUYAN, BETÜL; İZZETTİN, FIKRET VEHBIThis study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.Publication Metadata only Characteristics of the drug-disease information service demanded from the community pharmacist(2011-04-01T00:00:00Z) APIKOGLU-RABUS, S.; Pakalpakcil, O.; OKUYAN, BETÜL; SANCAR, MERT; Soydeger-Carli, B.; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIPublication Metadata only Turkish pharmacists- counseling practices and attitudes regarding emergency contraceptive pills(2012-08-01T00:00:00Z) Apikoglu-Rabus, Sule; Clark, Philip Martin; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIObjective The aim of this study is to assess Turkish pharmacists- counseling practices and attitudes regarding emergency contraception pills (ECPs). Setting This cross-sectional observational study was conducted via a web-based survey in Turkey. Methods Pharmacists registered at a professional web site (n = 822) were invited to fill in the study questionnaire; 624 questionnaires were completed and further analyzed. Pharmacists who agreed to participate in the study completed the questionnaire which was structured to elicit their demography, professional experience, counseling practices and attitudes regarding ECP. Attitudes were measured by 18 items under four domains: -reproductive health; information and availability; risk behavior and regulatory restrictions-. The answer choices consisted of five items as: -totally agree, agree, neither agree nor disagree, disagree and totally disagree-. Main outcome Measures The rate of counseling on various aspects of the ECPs and the rate of negative/positive attitudes. Results The aspects most frequently counseled on by the pharmacists were dosage, timeframes, efficacy and pregnancy testing. Less frequently counseled aspects were mechanism of action, methods of contraception and side-effects. In general, the pharmacists displayed positive attitudes towards all domains of the survey; while they were negative to the items suggesting that ECP should be sold only to women and only on prescription. Another interesting finding is that 58 % of the pharmacists agreed with the item suggesting limiting the ECP sales to those over 18 years of age. Conclusions Our results showed that the pharmacists served the clients in need of emergency contraception more frequently than the other health-care providers and in general had favorable attitudes towards ECP. Some aspects of their counseling practices need to be improved. This can be accomplished through continuous education programs that would equip them with the competence to provide counseling on emergency contraception which will in turn help prevent unintended pregnancies and reduce abortion rates.Publication Open Access Determination of Potential Drug-Drug Interactions Using Various Software Programs in a Community Pharmacy Setting(2019-03-01T00:00:00Z) SANCAR, MESUT; Kasik, Aksa; OKUYAN, BETÜL; Batuhan, Sevda; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIObjectives: The aim of the present study was to compare various software programs in detecting potential drug-drug interactions in a community pharmacy setting. Materials and methods: Details of prescriptions were collected from 50 community pharmacies located in İstanbul in March and April 2015 (two days per week). From each pharmacy, the first 20 prescriptions that included more than one drug were collected to evaluate potential drug-drug interactions. The following software programs were utilized to detect potential drug-drug interactions: micromedexsolutions.com, medscape.com, and drugs.com. The number of potential interactions detected by the software programs was determined. Results: At least one potential drug-drug interaction was detected in 39.2% of the 1000 prescriptions by one of the software programs. According to the rates of total drug-drug interactions gathered from various software programs, these programs gave the following results: medscape.com 33.3%, drugs.com 31.3%, and micromedexsolutions.com 21.2%. Conclusion: After comparing different software programs, the potential drug-drug interactions found by the programs proved to be different. Therefore, we recommend that pharmacists confirm with a different program before making a decision when they detect clinically significant potential drug-drug interactions.Publication Metadata only Comparison of conditioning regimen toxicities among autologous stem cell transplantation eligible multiple myeloma patients: High-dose melphalan versus high-dose melphalan and bortezomib(2018-06-01T00:00:00Z) Aypar, Eda; Izzettin, FİKRET VEHBİ; Aki, Sahika Zeynep; SANCAR, MESUT; Yegin, Zeynep Arzu; Turkoz-Sucak, Gulsan; İZZETTİN, FIKRET VEHBIBackground Autologous hematopoietic stem cell transplantation (AHSCT) remains the standard of care for younger patients with multiple myeloma (MM). Currently, high-dose melphalan (HDM) is recommended as conditioning regimen before AHSCT. Preclinical data suggest that combining bortezomib and melphalan has synergistic effect against multiple myeloma cells. Bortezomib and HDM (Bor-HDM) combination as conditioning regimen has been investigated by many other investigators.Publication Metadata only How much do the faculty courses contribute to daily pharmacy practice?(2011-04-01T00:00:00Z) APIKOGLU-RABUS, S.; SANCAR, MERT; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIPublication Metadata only Outcomes of diabetes risk-testing performed at community pharmacy setting(2011-04-01T00:00:00Z) APIKOGLU-RABUS, S.; Ture, Z.; SANCAR, MERT; OKUYAN, BETÜL; Soydeger-Carli, B.; YILMAZ, ZAHİT; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBI