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Now showing 1 - 6 of 6
  • PublicationMetadata only
    Relationship between fecal calprotectin level and disease activity in patients with hidradenitis suppurativa
    (2020-03-01T00:00:00Z) Eser, Emel; Engin, Burhan; Yuksel, PELİN; Kocazeybek, Bekir Sami; Kutlubay, Zekayi; Serdaroglu, Server; Askin, Ozge; YÜKSEL MAYDA, PELİN
    Background Hidradenitis suppurativa is a chronic, inflammatory, recurrent disease with recurrent abscesses, and sinus tract formation leading to scarring. Calprotectin has immunomodulatory, antimicrobial, and antiproliferative properties and is a calcium-binding protein primarily found in the neutrophil cytoplasm. In recent years, a significant relationship between the activity of various diseases and the level of calprotectin has led to the conclusion that there may be a similar relationship in hidradenitis suppurativa.
  • PublicationOpen Access
    Clostridium difficile Colonization Before and After Hospitalization in Children
    (2021-11-01T00:00:00Z) Rzayev, Turkay; YÜKSEL MAYDA, PELİN; ERKAN, Tülay; KOCAZEYBEK, Bekir Sami; KUTLU, Hüseyin Tufan; YÜKSEL MAYDA, PELİN
    Background: Beginning in the early 2000s, Clostridium difficile infection has become a major health problem in the United States, Canada, and in most European countries and has not only increased in incidence but also the severity. There are 2 conditions for the development of C. difficile infection: disruption of the normal gastrointestinal flora, and exogenous ingestion of the microorganism. We aimed to study C. difficile colonization in hospitalized children. We identified 2 issues: (1) the relationship between risks before hospital admission and colonization on the first day of hospitalization and (2) the effect of the factors that patients are exposed to during hospitalization on the colonization status at discharge. Methods: Patients aged between 2 and 18 years who were hospitalized with various diagnoses were included in this study. C. difficile toxin A/B was investigated in the stool samples taken on the admission and discharge days. Results: One hundred six patients were included in the study, of whom 24.5% and 48.1% of hemato-oncology patients were positive for C. difficile toxin A/B. Antibiotic usage within 1 month preceding hospitalization and the presence of underlying disease impact the C. difficile colonization status on the first day of hospitalization. Conclusion: Toxigenic C. difficile colonization prevalence is high in hospitalized children, especially in the hemato-oncology patient group.
  • PublicationMetadata only
    The role of typical and atypical pathogens in acute exacerbations of chronic obstructive pulmonary disease
    (2020-10-01T00:00:00Z) Yildiz, Sevilay; GÖNÜLLÜ, Nevriye; Yildiz, Birsen Pinar; Hattatoglu, Didem Gorgun; Kuskucu, Mert; MİDİLLİ, Kenan; AYGÜN, Gökhan; YÜKSEL MAYDA, PELİN; Musellim, Benan; YÜKSEL MAYDA, PELİN
    Objectives The exact role of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila in the development of chronic obstructive pulmonary disease exacerbations remains to be elucidated. This study was conducted to identify nonspecific and atypical pathogens associated with acute exacerbations of COPD.
  • PublicationOpen Access
    History of Epidemics and COVID-19
    (2020-12-01T00:00:00Z) YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    In archaeological excavations, it has been reported that formations resembling bacterial fossils are found among the rock layers and they belong to millions of years ago. There are those who have created the flora and preserved us by creating our flora, and those that have brought us to the end, as well as those that help us to form the microorganisms that we share with the same planet, whose existence dates back to ancient times. Although our immune system and medical facilities are trump cards against microorganisms living in the world for much longer than human beings, these are not always enough to protect us, and microorganisms are causing outbreaks that will make history. In this review, we aimed to examine the epidemic diseases experienced by human beings from past to present and their effects.
  • PublicationMetadata only
    Point Mutations at gyrA and gyrB Genes of Levofloxacin Resistant Helicobacter pylori Strains and Dual Resistance with Clarithromycin
    (2021-01-01T00:00:00Z) Ziver-Sarp, Tevhide; YÜKSEL MAYDA, PELİN; Saribas, Suat; DEMİRYAS, Süleyman; Gareayaghi, Nesrin; ERGİN, Sevgi; TAŞÇI, İhsan; Ozbey, Dogukan; BAL, Kadir; Erzin, Yusuf; AKKUŞ, Seher; BAHAR TOKMAN, Hrisi; Demirci, Mehmet; Tufan-Kocak, Banu; KOCAZEYBEK, Bekir Sami; YÜKSEL MAYDA, PELİN
    Background: Spontaneous point mutations in genes encoding gyrA/B subunits of DNA gyrase are responsible for fluoroquinolone resistance. We aimed to determine the clarithromycin and levofloxacin resistance phenotypically in H. pylori strains and to investigate the mutations responsible for levofloxacin resistance and the effects of these mutations on dual antibiotic resistance. Methods: A total of 65 H. pylori isolates were included. The E-test method was used for the clarithromycin and le-vofloxacin antimicrobial susceptibility test. Real-time PCR was used to detect the point mutations. Results: Twenty-four (36.9%) of 65 H. pylori strains were phenotypically resistant to clarithromycin and 14 (21.5%) to levofloxacin. The phenotypic levofloxacin resistance rate of strains with Asn87Lys and Asp91Asn mu-tations were significantly higher (gyrA gene) (p < 0.05). The phenotypic levofloxacin resistance rate of strains with Arg484Lys and Asp481Glu mutations were significantly higher (gyrB gene) (p < 0.05). The Asn87Lys mutation in-creased the risk of phenotypes being resistant to levofloxacin 70.156 times and Asp91Asn mutation increased 125,427 times higher. Seven (10.8%) of 65 H. pylori strains showed dual resistance to both levofloxacin and cla-rithromycin. The rate of being dual resistant with A2143G mutation (clarithromycin resistance) was found to be significantly higher (p < 0.05). Conclusions: The Asn87Lys and Asp91Asn mutations in the gyrA gene had a phenotypically enhancing effect on levofloxacin resistance, while the presence of Asp481Glu and Arg484Lys mutations in the gyrB gene did not. The existence of dual resistance was developed with the increase in clarithromycin and levofloxacin resistance rates. (Clin. Lab. 2021;67:2369-2377. DOI: 10.7754/Clin.Lab.2021.210843)
  • PublicationOpen Access
    SARS CoV-2 Pathogenesis and Immune Response
    (2020-12-01T00:00:00Z) Dinç, Harika Öykü; Yüksel Mayda, Pelin; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
    The agent responsible for the epidemic that first appeared in Wuhan, China, in December 2019 was detected to be the new coronavirus (2019-nCoV). Later, the virus that caused respiratory tract infection was discovered to be a member of the beta-coronavirus family, it was named as severe acute respiratory syndrome-CoV2 (SARS-CoV 2), and the disease it caused was called CoV infection disease-19 (COVID-19). The epidemic started in China, spread rapidly first to East Asian countries, then Europe and America, affected the whole world, and was declared a pandemic by the World Health Organization. This review presents an overview of SARS-CoV2 and aims to examine its intracellular pathogenesis and host immune responses.