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Now showing 1 - 3 of 3
  • PublicationMetadata only
    Relationship between fecal calprotectin level and disease activity in patients with hidradenitis suppurativa
    (2020-03-01T00:00:00Z) Eser, Emel; Engin, Burhan; Yuksel, PELİN; Kocazeybek, Bekir Sami; Kutlubay, Zekayi; Serdaroglu, Server; Askin, Ozge; YÜKSEL MAYDA, PELİN
    Background Hidradenitis suppurativa is a chronic, inflammatory, recurrent disease with recurrent abscesses, and sinus tract formation leading to scarring. Calprotectin has immunomodulatory, antimicrobial, and antiproliferative properties and is a calcium-binding protein primarily found in the neutrophil cytoplasm. In recent years, a significant relationship between the activity of various diseases and the level of calprotectin has led to the conclusion that there may be a similar relationship in hidradenitis suppurativa.
  • PublicationMetadata only
    The role of typical and atypical pathogens in acute exacerbations of chronic obstructive pulmonary disease
    (2020-10-01T00:00:00Z) Yildiz, Sevilay; GÖNÜLLÜ, Nevriye; Yildiz, Birsen Pinar; Hattatoglu, Didem Gorgun; Kuskucu, Mert; MİDİLLİ, Kenan; AYGÜN, Gökhan; YÜKSEL MAYDA, PELİN; Musellim, Benan; YÜKSEL MAYDA, PELİN
    Objectives The exact role of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila in the development of chronic obstructive pulmonary disease exacerbations remains to be elucidated. This study was conducted to identify nonspecific and atypical pathogens associated with acute exacerbations of COPD.
  • PublicationMetadata only
    Point Mutations at gyrA and gyrB Genes of Levofloxacin Resistant Helicobacter pylori Strains and Dual Resistance with Clarithromycin
    (2021-01-01T00:00:00Z) Ziver-Sarp, Tevhide; YÜKSEL MAYDA, PELİN; Saribas, Suat; DEMİRYAS, Süleyman; Gareayaghi, Nesrin; ERGİN, Sevgi; TAŞÇI, İhsan; Ozbey, Dogukan; BAL, Kadir; Erzin, Yusuf; AKKUŞ, Seher; BAHAR TOKMAN, Hrisi; Demirci, Mehmet; Tufan-Kocak, Banu; KOCAZEYBEK, Bekir Sami; YÜKSEL MAYDA, PELİN
    Background: Spontaneous point mutations in genes encoding gyrA/B subunits of DNA gyrase are responsible for fluoroquinolone resistance. We aimed to determine the clarithromycin and levofloxacin resistance phenotypically in H. pylori strains and to investigate the mutations responsible for levofloxacin resistance and the effects of these mutations on dual antibiotic resistance. Methods: A total of 65 H. pylori isolates were included. The E-test method was used for the clarithromycin and le-vofloxacin antimicrobial susceptibility test. Real-time PCR was used to detect the point mutations. Results: Twenty-four (36.9%) of 65 H. pylori strains were phenotypically resistant to clarithromycin and 14 (21.5%) to levofloxacin. The phenotypic levofloxacin resistance rate of strains with Asn87Lys and Asp91Asn mu-tations were significantly higher (gyrA gene) (p < 0.05). The phenotypic levofloxacin resistance rate of strains with Arg484Lys and Asp481Glu mutations were significantly higher (gyrB gene) (p < 0.05). The Asn87Lys mutation in-creased the risk of phenotypes being resistant to levofloxacin 70.156 times and Asp91Asn mutation increased 125,427 times higher. Seven (10.8%) of 65 H. pylori strains showed dual resistance to both levofloxacin and cla-rithromycin. The rate of being dual resistant with A2143G mutation (clarithromycin resistance) was found to be significantly higher (p < 0.05). Conclusions: The Asn87Lys and Asp91Asn mutations in the gyrA gene had a phenotypically enhancing effect on levofloxacin resistance, while the presence of Asp481Glu and Arg484Lys mutations in the gyrB gene did not. The existence of dual resistance was developed with the increase in clarithromycin and levofloxacin resistance rates. (Clin. Lab. 2021;67:2369-2377. DOI: 10.7754/Clin.Lab.2021.210843)