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Now showing 1 - 10 of 18
  • PublicationMetadata only
    Can the nucleic acid amplification test (NAT) be an alternative to the serologic tests? A prospective study, the results of 18,200 blood donors from the Turkish Red Crescent
    (2010-12-01T00:00:00Z) Kosan, Erdogan; Kocazeybek, Bekir; Altunay, Husnu; Aymelek, Meryem; Alan, Esra; Saribas, Suat; Aslan, Mustafa; Yenen, Osman Sadi; Yuksel, PELİN; Birinci, Ilhan; Kirali, Kaan; Aksoy, Armagan; YÜKSEL MAYDA, PELİN
    Aim: Serologic tests having high sensitivity and specificity are used in order to prevent contamination with infectious agents from blood and blood products for transfusion safety. The present serologic tests have problems such as low sensitivity and weak detection capacity of infectious agents in the -window period-. We aimed to test the use of NAT (Nucleic Acid Amplification Test) in routine blood screening in the Blood Bank.
  • PublicationMetadata only
    Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey
    (2015-05-01T00:00:00Z) Caliskan, Reyhan; Tokman, Hrisi Bahar; Erzin, Yusuf; Saribas, Suat; Yuksel, Pelin; Bolek, Bora Kazim; Sevuk, Ecehan Ozge; Demirci, Mehmet; Yilmazli, Ozge; Akgul, Ozer; Kalayci, Fatma; Cakan, Huseyin; Salih, Barik; Bal, Kadir; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN
    Introduction: Antibiotic resistance is the main factor that affects the efficacy of current therapeutic regimens against Helicobacter pylori. This study aimed to determine the rates of resistance to efficacy clarithromycin, amoxicillin, tetracycline, levofloxacin and metronidazole among H. pylori strains isolated from Turkish patients with dyspepsia. Methods: H. pylori was cultured from corpus and antrum biopsies that were collected from patients with dyspeptic symptoms, and the antimicrobial susceptibility of H. pylori was determined using the E-test (clarithromycin, amoxicillin, tetracycline, metronidazole and levofloxacin) according to the EUCAST breakpoints. Point mutations in the 23S rRNA gene of clarithromycin-resistant strains were investigated using real-time PCR. Results: A total of 98 H. pylori strains were isolated, all of which were susceptible to amoxicillin and tetracycline. Of these strains, 36.7% (36/98) were resistant to clarithromycin, 35.5% (34/98) were resistant to metronidazole, and 29.5% (29/98) were resistant to levofloxacin. Multiple resistance was detected in 19.3% of the isolates. The A2143G and A2144G point mutations in the 23S rRNA-encoding gene were found in all 36 (100%) of the clarithromycin-resistant strains. Additionally, the levofloxacin MIC values increased to 32 mg/L in our H. pylori strains. Finally, among the clarithromycin-resistant strains, 27.2% were resistant to levofloxacin, and 45.4% were resistant to metronidazole. Conclusions: We conclude that treatment failure after clarithromycin-or levofloxacin-based triple therapy is not surprising and that metronidazole is not a reliable agent for the eradication of H. pylori infection in Turkey.
  • PublicationMetadata only
    The importance of transmission time in HIV infections and an epidemiological prospective follow-up study for 1year in the Marmara Region of Turkey
    (2012-08-01T00:00:00Z) Celik, Deniz Gozde; Yuksel, PELİN; Aslan, Mustafa; Saribas, Suat; BALTALI, Nezihe Dirik; Abdelkareem, Ali; Ziver, Tevhide; NAZLICAN, Ozcan; GENCER, Serap; CELIKKOL, Erdoĝan; BAHAR, Hrisi; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN
  • PublicationMetadata only
    Problems encountered in conventional HIV 1/2 algorithms: Lack of necessity for immunoblot assays to confirm repeated ELISA reactive results
    (2018-06-01T00:00:00Z) Yuksel, Pelin; Saribas, Suat; Kuskucu, Mert; Mutcali, Sibel Islak; Kosan, Erdogan; Habip, Zafer; Demirci, Mehmet; Kara, Eda Salihoglu; Birinci, Ilhan; Caliskan, Reyhan; Dinc, HARİKA ÖYKÜ; Midilli, Kenan; Ziver, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    Background: The use of conventional (serologically based) HIV 1/2 diagnostic algorithms has become controversial in recent years.
  • PublicationOpen Access
    Diagnostic performance of the RT-qPCR method targeting 85B mRNA in the diagnosis of pulmonary Mycobacterium tuberculosis infection
    (2018-09-01T00:00:00Z) Demirci, Mehmet; Saribas, Suat; Ozer, Nigar; TOPRAK, Sezer; CAGLAR, Emel; ORTAKOYLU, Gonenc; Yuksel, PELİN; Ayaz, Gulsel; Tokman, Hrisi B.; Uysal, Omer; Dinc, HARİKA ÖYKÜ; ZİVER, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; UYSAL, ÖMER; DİNÇ, HARİKA ÖYKÜ
    Background: Several nucleic acid amplification techniques (IS6110, 16S rRNA, and 85B mRNA) were developed for the rapid, direct detection of Mycobacterium tuberculosis. We aimed to assess the diagnostic performance of 85B mRNA-based RT-qPCR by comparing with the real-time PCR COBAS TagMan MTB Kit while using the BACTEC MGIT 960 method as the gold standard.
  • PublicationMetadata only
    The relationship of Chlamydophila pneumoniae with schizophrenia: The role of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in this relationship
    (2017-01-01T00:00:00Z) Kalayci, Fatma; Ozdemir, Armagan; Saribas, Suat; Yuksel, Pelin; Ergin, Sevgi; Kuskucu, Ali Mert; Poyraz, Cana Aksoy; Balcioglu, Ibrahim; Alpay, Nihat; Kurt, Aykut; Sezgin, Zeynep; Kocak, Banu Tufan; Icel, Rana Sucu; Can, Gunay; Tokman, Hrisi Bahar; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN
    Several pathogens have been suspected of playing a role in the pathogenesis of schizophrenia. Chronic inflammation has been proposed to occur as a result of persistent infection caused by Chlamydophila pneumoniae cells that reside in brain endothelial cells for many years. It was recently hypothesized that brain-derived neurotrophic factor ( BDNF) and neurotrophin-3 (NT-3) may play prominent roles in the development of schizophrenia. NT3 and BDNF levels have been suggested to change in response to various manifestations of infection. Therefore, we aimed to elucidate the roles of BDNF and NT3 in the schizophrenia-C. pneumoniae infection relationship. RT-PCR, immunofluorescence and ELISA methods were used. Fifty patients suffering from schizophrenia and 35 healthy individuals were included as the patient group (PG) and the healthy control group (HCG), respectively. We detected persistent infection in 14 of the 50 individuals in the PG and in 1 of the 35 individuals in the HCG. A significant difference was found between the two groups (p 0.05). C. pneumoniae DNA was not detected in any group. A significant difference in NT-3 levels was observed between the groups, with very low levels in the PG (p 0.05). In conclusion, we suggest that NT-3 levels during persistent C. pneumoniaeinfection may play a role in this relationship. (C) 2016 Asociaci on Argentina de Microbiologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license
  • PublicationMetadata only
    Microorganisms in Respiratory Tract of Patients Diagnosed with Atypical Pneumonia: Results of a Research Based on the Use of Reverse Transcription Polymerase Chain Reaction (RT-PCR) DNA Microarray Method and Enzyme-Linked Immunosorbent Assay
    (2014-01-01T00:00:00Z) Tokman, Hrisi Bahar; Aslan, Mustafa; Ortakoylu, Gonenc; Algingil, Reyhan Caliskan; Yuksel, Pelin; Karakullukcu, Asiye; Kalayci, Fatma; Saribas, Suat; Cakan, Huseyin; Demir, Tuncalp; Kocazeybek, Bekir S.; YÜKSEL MAYDA, PELİN
    Background: Numerous molecular-based tests were applied for the laboratory-based diagnosis of viruses. In this cross-sectional case control study, in addition to bacteria, we aimed to determine respiratory viruses using, for the first time in our country, the Reverse Transcription PCR DNA Microarray method, and we also aimed to evaluate its diagnostic performance.
  • PublicationMetadata only
    Comparison of new and classical point mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from dyspeptic patients and their effects on phenotypic clarithromycin resistance
    (2019-04-01T00:00:00Z) Kocazeybek, Bekir; Sakli, Merve Kutlu; Yuksel, PELİN; Demirci, Mehmet; Caliskan, Reyhan; Sarp, Tevhide Ziver; Saribas, Suat; Demiryas, Suleyman; Kalayci, Fatma; Cakan, Huseyin; Uysal, Hayriye Kirkoyun; GAREAYAGHİ, Nesrin; Ergin, Sevgi; Erzin, Yusuf Ziya; Bal, Kadir; Tasci, Ihsan; Tokman, Hrisi Bahar; YÜKSEL MAYDA, PELİN
    Purpose. We aimed to investigate the presence of three recently identified point mutations (A2115G, G2141A and A2144T) of the 23 S rRNA gene and compare them with the three most frequently encountered point mutations (A2142G, A2142C and A2143G) in Helicobacter pylori strains in Turkey.
  • PublicationMetadata only
    Evaluation of Adenovirus-36 (Ad-36) antibody seropositivity and adipokine levels in obese children
    (2017-07-01T00:00:00Z) Kocazeybek, Bekir; Dinc, HARİKA ÖYKÜ; Ergin, Sevgi; Saribas, Suat; Ozcabi, Bahar Taskm; Cizmecigil, Utku; Altan, Eda; Atalik, Keyser; Yuksel, Pelin; Taner, Zeynep; Karakullukcu, Asiye; Sirekbasan, Serhat; Turan, Nuri; Cagatay, Penbe; Imamova, Nergiz; Evliyaoglu, Olcay; Yilmaz, Huseyin; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
    Adenovirus 36 (Ad-36) has recently been suggested as a possible contributor to the current obesity epidemic. The aim of this study was to investigate the prevalence of Ad-36 antibodies in obese children, as well as investigate the role of serum leptin and lipid levels in Ad-36-obesity. Seventy-one obese children and 62 non-obese children were included as the patient group (PG), including the healthy control group (HCG), respectively. Simultaneously, Ad-36 antibodies and adipokine levels were assessed with serum neutralization assays (SNA) and ELISA. Ad-36 antibody was detected in 9 patients (12.7%) and 1 patient (1.6%) in both the PG and HCG, respectively, while a significant difference was detected between groups (p < 0.05). Although serum LDL, total cholesterol, triglycerides and leptin levels were detected significantly higher, adiponectin level was detected paradoxically lower in the PG. However, a significant difference was not detected for lipids and leptin levels; adiponectin levels were found to be significantly lower in Ad-36 antibody-positive PG (p < 0.05).
  • PublicationMetadata only
    Travel-associated infections caused by unusual serogroups of Legionella pneumophila identified using Legionella BIOCHIP slides in Turkey and Iraq
    (2016-05-01T00:00:00Z) Kocazeybek, Bekir S.; Yuksel, Pelin; Keskin, Dilek; Sheikh, Suhail; Habip, Zafer; Yavuzer, Serap Sahin; Caliskan, Reyhan; Altun, Yagiz Meric; Kuskucu, Mert; Cengiz, Mahir; Dinc, HARİKA ÖYKÜ; Karakullukcu, Asiye; Ergin, Sevgi; Saribas, Suat; Yilmaz, Nail; Tokman, Hrisi Bahar; YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    Background: Although Legionella pneumophila serogroup 1 is the common disease causing serogroup, rare serogroups can also may cause legionellosis. A 54-year-old male patient (index case) reported that he had been on a religious trip (for visiting, tomb of Ali, which is important for Shias) to Iraq with a large group (50 shia pilgrims from Kars city of Turkey) two weeks prior to admission. Due to civil war, the hotel where the patient stayed in Iraq lacked proper hygiene. A large number of people in the travel group were experiencing the same symptoms. Other five cases were 2 males (ages; 50, 45) and 3 females including the wife of the index case (ages; 50, 28, 27).