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ÇETİN, ÇAĞLAR

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Now showing 1 - 10 of 11
  • PublicationMetadata only
    Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model
    (2023-01-01) Okten S. B.; ÇETİN Ç.; Tok O. E.; Guler E. M.; Taha S. H.; ÖZCAN P.; Ficicioglu C.; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR
    Research question: Can cannabidiol (CBD) be used in the treatment of endometriosis for its anti-inflammatory, antioxidative and antiangiogenic effects? Design: Endometrial implants were surgically induced in 36 female Wistar albino rats. After confirmation of endometriotic foci, the rats were randomized into four groups. In the leuprolide acetate group, rats were given a single 1 mg/kg s.c. leuprolide acetate injection. The other groups were 5 mg/kg CBD (CBD5), saline solution and 20 mg/kg CBD (CBD20); daily i.p. injections were administered for 7 days. After 21 days, the rats were euthanised, and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) measurements in blood and peritoneal fluid samples, and immunohistochemical staining for TNF-α, IL-6 and vascular endothelial growth factor (VEGF) of endometriotic tissues were evaluated. Results: Significant reductions in the endometriotic implant surface area (P = 0.0213), serum TOS (P = 0.0491), OSI (P = 0.0056), IL-6 (P = 0.0236), TNF-α (P = 0.0083) and peritoneal fluid OSI (P = 0.0401), IL-6 (P = 0.0205) and TNF-α (P = 0.0045) concentrations were observed in the CBD5 group when compared with the saline solution group. Compared with the saline solution group, increased TAS concentrations in serum (P = 0.0012) and peritoneal fluid (P = 0.0145) were found in the CBD5 group. The CBD5 and leuprolide acetate groups were similar regarding inflammatory and oxidative stress parameters of serum and peritoneal fluid samples. The CBD5 group showed significantly lower mean intensity in both surface epithelium and stromal cells for VEGF (both P = 0.002) and only in surface epithelium cells for IL-6 (P = 0.0108), when compared with the leuprolide acetate group. Conclusion: Due to its anti-inflammatory, antioxidative and antiangiogenic effects, CBD might be a therapeutic agent candidate for endometriosis.
  • PublicationMetadata only
    The Role of the Urine Dipstick Test in the Detection of Abnormal Proteinuria Using Different Cut-off Levels in Hypertensive Pregnancies Hipertansif Gebeliklerde Farklı Kesim Değerleri Kullanılarak Anormal Proteinüri Saptanmasında Spot İdrar Protein Ölçümünün Rolü
    (2022-01-01) Takmaz T.; Gorchiyeva I.; Arici Halici B. N.; TOPRAK A.; ÇETİN Ç.; KÜTÜK M. S.; TAKMAZ, TAHA; ARICI HALICI, BELFİN NUR; TOPRAK, ALİ; ÇETİN, ÇAĞLAR; KÜTÜK, MEHMET SERDAR
    © 2022, Duzce University Medical School. All rights reserved.Aim: The aim of this study was to determine the diagnostic accuracy of different urine dipstick protein threshold levels in predicting the presence of abnormal proteinuria in pregnant women with hypertension. Material and Methods: A total of 326 singleton pregnant women who underwent 501 urine protein tests and who had suspected preeclampsia were included in this retrospective study. Patient data was taken including medical and obstetric history. The results of dipstick urinalysis and concurrent 24-hour urine protein excretion measurements were compared to determine the accuracy of urinalysis. Results: A dipstick result of 1+ was found to be the best cut-off to predict 500 mg of protein excretion per day, with sensitivity and specificity of 62.09% and 88.97%, respectively. A 2+ proteinuria dipstick cut-off had high specificity and positive predictive value (PPV) (99.05% and 98.84%, respectively) for the prediction of 300 mg of protein excretion per day; this cut-off had low sensitivity (21.46%). A cut-off of 1+ also provided satisfactory specificity and PPV (91.43% and 94.48%, respectively) for the detection of 300 mg of protein excretion per day, but sensitivity was compromised (38.89%). Among 301 patients with negative dipstick results, 212 had a 24-hour urine protein extraction greater than 300 mg, with a false negative rate of 70.43%. Conclusion: The results suggest that the urine protein dipstick measurement has limited quantitative ability for the prediction of abnormal proteinuria. Additionally, the use of 500 mg 24-hours protein excretion as a cut-off value for abnormal proteinuria may provide useful data.
  • PublicationMetadata only
    Evaluation of chronotype and sleep quality in infertile population and comparison with fertile population: a cross-sectional study
    (2023-12-01) Özçelik C.; VARLI B.; Gökçe A.; Takmaz T.; ÇETİN Ç.; ÖZCAN P.; TAKMAZ, TAHA; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR
    PURPOSE: Infertility is a stressful condition for couples and can affect patients\" circadian rhythm and sleep quality. The goal of this study is to assess differences in chronotype and sleep quality between infertile and fertile people. METHODS: A cross-sectional study was conducted. The infertile patient population consisted study group. Primiparous patients without any known gynecological disease who presented for routine cervical cancer screening follow-up were included in the control group. The Turkish version of the Morningness-Eveningness Questionnaire (MEQ) and Pittsburg Sleep Quality Index (PSQI) scores were evaluated between groups. RESULTS: A total of 227 patients were assessed. There were 110 patients in the study (infertile) group and 117 patients in the control (fertile) group. The evening chronotype proportion (23.6 vs. 0.9%, p < 0.001) was higher in the infertile group. The median of MEQ score was significantly higher in the fertile patients (50, IQR = 43 - 55 vs. 56, IQR = 51 - 59; p < 0.001), and the median of PSQI score was significantly higher in the infertile patients (5, IQR = 4 - 6, vs. 4, IQR = 3 - 5; p < 0.001). CONCLUSIONS: In this study, we found significantly worse sleep quality, and more evening chronotype in the patients with infertility.
  • PublicationMetadata only
    Excision of subcutaneous endometriosis lesions in obese patients by marking them with methylene blue with ultrasound guidance: a novel technique
    (2023-01-01) ÇETİN Ç.; KÜTÜK M. S.; Tanoğlu F. B.; ATEŞ S.; ÖZCAN P.; BAKAR R. Z.; ÇETİN, ÇAĞLAR; KÜTÜK, MEHMET SERDAR; TANOĞLU, FATMA BAŞAK; ATEŞ, SEDA; ÖZCAN, PINAR; BAKAR, RABIA ZEHRA
  • PublicationMetadata only
    Comparison of Patients with Trucut Biopsy , Acid Cytology with Final Pathology Results from Patients Operated with Prediagnose of Ovarian Cancer
    (2022-10-30) Tanoğlu F. B.; Çetin Ç.; Pasin Ö.; Kıran G.; ÇETİN, ÇAĞLAR; PASİN, ÖZGE; KIRAN, GÜRKAN
  • PublicationMetadata only
    The effects of maternal smoking on fetal cranial development. Findings from routine midtrimester sonographic anomaly screening
    (2023-12-01) ÇETİN Ç.; BAKAR R. Z.; Takmaz T.; PASİN Ö.; KÜTÜK M. S.; ÇETİN, ÇAĞLAR; BAKAR, RABIA ZEHRA; PASİN, ÖZGE; KÜTÜK, MEHMET SERDAR
    The aim of this study was to assess the effect of continued smoking before and during pregnancy on mid-trimester fetal head development. A total of 250 pregnant women enrolled in the study. All participants were confirmed to be smokers or non-smokers by verifying breath carbon monoxide readings. Biparietal diameter (BPD), head circumference (HC), lateral ventricle (LV), and cisterna magna (CM) were evaluated by ultrasound between 20-22 weeks of pregnancy. Gender and gestational age-adjusted BPD z- scores were not statistically different between smokers and non-smokers (-0.75 ± 1.6 vs -0.51 ± 1, p = .3). HC measurements and z- scores were significantly lower in the smoking group than in the non-smoking groups (183.38 ± 14.56 vs. 189.28 ± 12.53, p = .003, 0.18 ± 1.39 multiple of median (MoM) vs. 0.56 ± 0.92, respectively, p = .023). At linear regression analysis, maternal smoking was the only independent factor associated with fetal HC z score (p = .041). In conclusion, continued smoking during pregnancy reduces fetal HC and has no effect on BPD, LV, or CM measurements at mid-gestation.IMPACT STATEMENTWhat is already known on this subject? Smoking during pregnancy is one of the most common environmental factors affecting fetal and neonatal growth and well-being. Despite the well-known effects of smoking on somatic growth, current studies have shown that it selectively affects some parts of the fetal brain, even in appropriately growing fetuses.What do the results of this study add? Continued smoking during pregnancy reduces fetal HC and has no effect on BPD, LV or CM measurements at mid-gestation. Since smoking is well known for its early and late childhood behavioral and neurological consequences, smaller mid-trimester fetal HC measurements should bring maternal smoking to mind as one of the potentially reversible causes.What are the implications of these findings for clinical practice and/or further research? The harmful effects of smoking start before the third trimester and antenatal counseling should be started early in the gestation. Every effort should be made to quit smoking before or early in pregnancy.
  • PublicationMetadata only
    Intrauterine Insemination, IVF/ICSI Intrauterin Inseminasyon, IVF/ICSI
    (2022-10-30) ÇETİN Ç.; ÖZCAN P.; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR
    © 2022, Duzce University Medical School. All rights reserved.Infertility is defined as the inability to conceive after one year despite regular intercourse. The need for treatment and treatment option are determined by the evaluation process that starts after this stage. Treatment mainly includes ovarian stimulation followed by timed intercourse, intrauterine insemination (IUI), and in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Choosing the appropriate patient and appropriate treatment method is critical here and is based on many factors. Maternal age and infertility etiology are the main determinants of treatment selection. As important as it is to think about IVF/ICSI selection quickly in patients over 38 years of age, it is equally important to switch to assisted reproductive techniques without waiting in the presence of very low sperm parameters. An inappropriate indication will fail even if the treatment is done in the best way. Appropriate patient selection and giving enough time to the patient in the treatment stages will increase success. In the presented article, IUI and IVF/ICSI patient selection criteria will be evaluated according to the causes of infertility. Here, the order in which the patient will be evaluated and the steps to be taken on the way to IVF/ICSI in the treatment of staged infertility will be evaluated in detail and descriptively.
  • PublicationMetadata only
    Effect of maternal smoking during pregnancy on fetal circulation and growth
    (2023-06-25) Kütük M. S.; Bakar R. Z.; Toluk Ö.; Çetin Ç.; Yozgat C. Y.; Doygun Ö.; KÜTÜK, MEHMET SERDAR; BAKAR, RABIA ZEHRA; TOLUK, ÖZLEM; ÇETİN, ÇAĞLAR
    Objective To understand the pathogenic mechanism of smoking on abnormal fetal growth by assessing the umbilical, and middle cerebral pulsatility index (MCA- PI, and UmA-PI, respectively) cerebroplacental ratio (CPR) and middle MCA peak systolic velocity (MCA-Vmax). Methods A hundred and eighty-one pregnant women were included in the study, 118 of whom were ever smoker and 62 were smoker. Smoking status of the cases were based on the participants statements and confirmed with breath CO test. Patients were undergo Doppler examination according to thecurrent guidelines at 24, 28, 32 and 36 weeks and the results were expressed as z- scores. UmA- PI, MCA-PI, CPR (MCI-PI/UmA-PI), MCA- Vmax were compared between control and smoking groups. As a subgroup analysis, effect of heavy smoking (>10/day) on fetal growth and Doppler indexes were also compared. Results Body mass index (BMI), gravida, rate of gestational hypertension and neonatal intensive care admission is significantly higher in smoking group. Birthweight and gestational age at birth was significantly higher in control group [3355 (1960.0-4660.0) vs 3162.5(550.0-4190.0), p=0.003, and274.0(250.0-294.0) vs. 271(175.0-288.0), p=0.015, respectively]. When controlled for confounding factors, no significant difference was detectedbetween smokers and control groups with regard to UmA-PI, MCA-PI, MCA- V Max and CPR, at 24 , 28 , 32 , 36 weeks. EFW at all gestational ages were significantly lower in smoker group (p=0.033). At subgroup analysis, no significant difference was detected between control and heavy smokers in terms of EFW and all Doppler parameters. Conclusion Smoking during pregnancy is associated decreased fetal growth and increased abnormal neonatal outcome. However, it has no demonstrable effect on any of the Doppler indexes and velocities at any given gestational ages. Abnormal effect of smoking on fetal growth seems not to operate throughimpaired uteroplacental circulation
  • PublicationMetadata only
    The efficacy of three regimes of uterotonic agents for prevention of postpartum hemorrhage at elective cesarean section: a prospective randomized clinical trial
    (2022-05-28) Çetin Ç.; Dural H. R.; Ateş S.; Tanoğlu F. B.; Kütük M. S.; Özcan P.; ÇETİN, ÇAĞLAR; ATEŞ, SEDA; KÜTÜK, MEHMET SERDAR; ÖZCAN, PINAR
  • PublicationMetadata only
    The Effects of Maternal Smoking on Thyroid Function: Findings from Routine First-Trimester Sonographic Anomaly Screening
    (2023-01-01) BAKAR R. Z.; ÇETİN Ç.; Yozgat C. Y.; KÜTÜK M. S.; BAKAR, RABIA ZEHRA; ÇETİN, ÇAĞLAR; KÜTÜK, MEHMET SERDAR
    Aim This study aimed to assess the effect of tobacco exposure on maternal thyroid function and investigate its relationship to subclinical hypothyroidism in pregnant women during the first trimester. Subjects and Method A comparison of maternal thyroid function was made on 45 smokers, who composed the study group, and 72 non-smokers, pregnant women, who constituted the control group. After determining smokers by questionnaire, carbon monoxide (CO) levels in the expiratory air of the participants in both groups were measured and recorded, and the smokers\" exposure was objectively confirmed. Results Smoking and non-smoking pregnant women were similar regarding body mass index (BMI). While the TSH and fT4 levels were respectively 1.48 mlU/L and 11.43 pmol/L in pregnant women who smoked, that ratio changed to 1.72 mlU/L and 11.17 pmol/L in the non-smokers\" group. But the differences between the groups were not statistically significant (p=0.239, p=0.179). Even though the rate of subclinical hypothyroidism was 8.9% in the smoking group, it was approximately 19.4% in the non-smoker group; the difference was not statistically significant (p=0.187). Conclusion This study proved that there is no statistically significant difference between maternal serum TSH and fT4 levels and the rate of subclinical hypothyroidism in smokers during pregnancy in the first trimester.