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ÇETİN, ÇAĞLAR

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ÇAĞLAR
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Now showing 1 - 4 of 4
  • PublicationMetadata only
    The effect of serum progesterone level on ET Day and the efficacy of rescue progesterone treatment on ongoing pregnancy rates with artificial FET cycles
    (2022-07-01T00:00:00Z) ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; Okten, B.; Tanoglu, F. B.; İŞLEK, HAVVA SEVDE; PASİN, ÖZGE; Ficicioglu, C.; ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; İŞLEK, HAVVA SEVDE; PASİN, ÖZGE
  • PublicationMetadata only
    The importance of serum progesterone concentration at embryo transfer day and effect of rescue additional progesterone during programmed artificial frozen embryo transfer cycles
    (2022-01-01T00:00:00Z) ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; Okten, Berkem; TANOĞLU, FATMA BAŞAK; Taha, Havva Sevde; Pasin, Ozge; Ficicioglu, Cem; ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; TANOĞLU, FATMA BAŞAK; PASİN, ÖZGE
    © 2022 Reproductive Healthcare Ltd.Research question: What is the efficacy and possible positive effect of additional rescue subcutaneous (s.c.) progesterone therapy for restoration of progesterone concentration on embryo transfer day and pregnancy rates during programmed artificial frozen embryo transfer (FET) cycles with vaginal progesterone tablet plus i.m. progesterone? Design: Multicentre prospective cohort study (NCT04769401) including a total of 238 programmed artificial FET between February 2021 and September 2021. Patients were divided into ≥10 ng/ml and <10 ng/ml according to serum progesterone concentrations on embryo transfer day; 25 mg of s.c. progesterone was added to patients with <10 ng/ml; blood samples were taken 2 days later. The primary outcome was the ongoing pregnancy rate. Results: The proportion of patients having ≥10 ng/ml serum progesterone concentrations on embryo transfer day was 70.7%. There was no statistically significant difference with regard to cumulative pregnancy rate, ongoing pregnancy rate and miscarriage between the groups (55.4% versus 61.5%, P = 0.4; 78.2% versus 72.5% per pregnancy, P = 0.5; 21.8% versus 27.5%, P = 0.5, respectively, ≥10 ng/ml and <10 ng/ml). Eighty-three per cent of patients with low serum progesterone concentrations on embryo transfer day reached an adequate progesterone concentration with rescue s.c. progesterone treatment; 90% of pregnancy rates in patients with serum progesterone concentrations <10 ng/ml on embryo transfer day were in patients who reached adequate serum progesterone concentrations with daily rescue s.c. progesterone treatment. Conclusions: The measurement of serum progesterone concentrations on embryo transfer day may create the opportunity for rescue progesterone administration on that day for patients who fail to reach adequate serum progesterone concentrations, achieving similar pregnancy rates without cancellation of the cycle.
  • PublicationMetadata only
    Comparison of Patients with Trucut Biopsy , Acid Cytology with Final Pathology Results from Patients Operated with Prediagnose of Ovarian Cancer
    (2022-10-30) Tanoğlu F. B.; Çetin Ç.; Pasin Ö.; Kıran G.; ÇETİN, ÇAĞLAR; PASİN, ÖZGE; KIRAN, GÜRKAN
  • PublicationMetadata only
    The effects of maternal smoking on fetal cranial development. Findings from routine midtrimester sonographic anomaly screening
    (2023-12-01) ÇETİN Ç.; BAKAR R. Z.; Takmaz T.; PASİN Ö.; KÜTÜK M. S.; ÇETİN, ÇAĞLAR; BAKAR, RABIA ZEHRA; PASİN, ÖZGE; KÜTÜK, MEHMET SERDAR
    The aim of this study was to assess the effect of continued smoking before and during pregnancy on mid-trimester fetal head development. A total of 250 pregnant women enrolled in the study. All participants were confirmed to be smokers or non-smokers by verifying breath carbon monoxide readings. Biparietal diameter (BPD), head circumference (HC), lateral ventricle (LV), and cisterna magna (CM) were evaluated by ultrasound between 20-22 weeks of pregnancy. Gender and gestational age-adjusted BPD z- scores were not statistically different between smokers and non-smokers (-0.75 ± 1.6 vs -0.51 ± 1, p = .3). HC measurements and z- scores were significantly lower in the smoking group than in the non-smoking groups (183.38 ± 14.56 vs. 189.28 ± 12.53, p = .003, 0.18 ± 1.39 multiple of median (MoM) vs. 0.56 ± 0.92, respectively, p = .023). At linear regression analysis, maternal smoking was the only independent factor associated with fetal HC z score (p = .041). In conclusion, continued smoking during pregnancy reduces fetal HC and has no effect on BPD, LV, or CM measurements at mid-gestation.IMPACT STATEMENTWhat is already known on this subject? Smoking during pregnancy is one of the most common environmental factors affecting fetal and neonatal growth and well-being. Despite the well-known effects of smoking on somatic growth, current studies have shown that it selectively affects some parts of the fetal brain, even in appropriately growing fetuses.What do the results of this study add? Continued smoking during pregnancy reduces fetal HC and has no effect on BPD, LV or CM measurements at mid-gestation. Since smoking is well known for its early and late childhood behavioral and neurological consequences, smaller mid-trimester fetal HC measurements should bring maternal smoking to mind as one of the potentially reversible causes.What are the implications of these findings for clinical practice and/or further research? The harmful effects of smoking start before the third trimester and antenatal counseling should be started early in the gestation. Every effort should be made to quit smoking before or early in pregnancy.