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ÇETİN, ÇAĞLAR

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ÇAĞLAR
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Now showing 1 - 4 of 4
  • PublicationMetadata only
    Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model
    (2023-01-01) Okten S. B.; ÇETİN Ç.; Tok O. E.; Guler E. M.; Taha S. H.; ÖZCAN P.; Ficicioglu C.; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR
    Research question: Can cannabidiol (CBD) be used in the treatment of endometriosis for its anti-inflammatory, antioxidative and antiangiogenic effects? Design: Endometrial implants were surgically induced in 36 female Wistar albino rats. After confirmation of endometriotic foci, the rats were randomized into four groups. In the leuprolide acetate group, rats were given a single 1 mg/kg s.c. leuprolide acetate injection. The other groups were 5 mg/kg CBD (CBD5), saline solution and 20 mg/kg CBD (CBD20); daily i.p. injections were administered for 7 days. After 21 days, the rats were euthanised, and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) measurements in blood and peritoneal fluid samples, and immunohistochemical staining for TNF-α, IL-6 and vascular endothelial growth factor (VEGF) of endometriotic tissues were evaluated. Results: Significant reductions in the endometriotic implant surface area (P = 0.0213), serum TOS (P = 0.0491), OSI (P = 0.0056), IL-6 (P = 0.0236), TNF-α (P = 0.0083) and peritoneal fluid OSI (P = 0.0401), IL-6 (P = 0.0205) and TNF-α (P = 0.0045) concentrations were observed in the CBD5 group when compared with the saline solution group. Compared with the saline solution group, increased TAS concentrations in serum (P = 0.0012) and peritoneal fluid (P = 0.0145) were found in the CBD5 group. The CBD5 and leuprolide acetate groups were similar regarding inflammatory and oxidative stress parameters of serum and peritoneal fluid samples. The CBD5 group showed significantly lower mean intensity in both surface epithelium and stromal cells for VEGF (both P = 0.002) and only in surface epithelium cells for IL-6 (P = 0.0108), when compared with the leuprolide acetate group. Conclusion: Due to its anti-inflammatory, antioxidative and antiangiogenic effects, CBD might be a therapeutic agent candidate for endometriosis.
  • PublicationMetadata only
    Evaluation of chronotype and sleep quality in infertile population and comparison with fertile population: a cross-sectional study
    (2023-12-01) Özçelik C.; VARLI B.; Gökçe A.; Takmaz T.; ÇETİN Ç.; ÖZCAN P.; TAKMAZ, TAHA; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR
    PURPOSE: Infertility is a stressful condition for couples and can affect patients\" circadian rhythm and sleep quality. The goal of this study is to assess differences in chronotype and sleep quality between infertile and fertile people. METHODS: A cross-sectional study was conducted. The infertile patient population consisted study group. Primiparous patients without any known gynecological disease who presented for routine cervical cancer screening follow-up were included in the control group. The Turkish version of the Morningness-Eveningness Questionnaire (MEQ) and Pittsburg Sleep Quality Index (PSQI) scores were evaluated between groups. RESULTS: A total of 227 patients were assessed. There were 110 patients in the study (infertile) group and 117 patients in the control (fertile) group. The evening chronotype proportion (23.6 vs. 0.9%, p < 0.001) was higher in the infertile group. The median of MEQ score was significantly higher in the fertile patients (50, IQR = 43 - 55 vs. 56, IQR = 51 - 59; p < 0.001), and the median of PSQI score was significantly higher in the infertile patients (5, IQR = 4 - 6, vs. 4, IQR = 3 - 5; p < 0.001). CONCLUSIONS: In this study, we found significantly worse sleep quality, and more evening chronotype in the patients with infertility.
  • PublicationMetadata only
    Excision of subcutaneous endometriosis lesions in obese patients by marking them with methylene blue with ultrasound guidance: a novel technique
    (2023-01-01) ÇETİN Ç.; KÜTÜK M. S.; Tanoğlu F. B.; ATEŞ S.; ÖZCAN P.; BAKAR R. Z.; ÇETİN, ÇAĞLAR; KÜTÜK, MEHMET SERDAR; TANOĞLU, FATMA BAŞAK; ATEŞ, SEDA; ÖZCAN, PINAR; BAKAR, RABIA ZEHRA
  • PublicationMetadata only
    Intrauterine Insemination, IVF/ICSI Intrauterin Inseminasyon, IVF/ICSI
    (2022-10-30) ÇETİN Ç.; ÖZCAN P.; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR
    © 2022, Duzce University Medical School. All rights reserved.Infertility is defined as the inability to conceive after one year despite regular intercourse. The need for treatment and treatment option are determined by the evaluation process that starts after this stage. Treatment mainly includes ovarian stimulation followed by timed intercourse, intrauterine insemination (IUI), and in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Choosing the appropriate patient and appropriate treatment method is critical here and is based on many factors. Maternal age and infertility etiology are the main determinants of treatment selection. As important as it is to think about IVF/ICSI selection quickly in patients over 38 years of age, it is equally important to switch to assisted reproductive techniques without waiting in the presence of very low sperm parameters. An inappropriate indication will fail even if the treatment is done in the best way. Appropriate patient selection and giving enough time to the patient in the treatment stages will increase success. In the presented article, IUI and IVF/ICSI patient selection criteria will be evaluated according to the causes of infertility. Here, the order in which the patient will be evaluated and the steps to be taken on the way to IVF/ICSI in the treatment of staged infertility will be evaluated in detail and descriptively.