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ÇETİN, ÇAĞLAR

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ÇAĞLAR
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ÇETİN
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Now showing 1 - 3 of 3
  • PublicationMetadata only
    Sleep, depression, anxiety and fatigue in women with premature ovarian insufficiency
    (2022-05-01T00:00:00Z) ATEŞ, SEDA; Aydin, Serdar; ÖZCAN, PINAR; BAKAR, Rabia Zehra; ÇETİN, ÇAĞLAR; ATEŞ, SEDA; ÖZCAN, PINAR; BAKAR, RABIA ZEHRA; ÇETİN, ÇAĞLAR
    Purpose To assess sleep disturbances, levels of anxiety, depression and fatigue in women with premature ovarian insufficiency (POI). Materials and methods The study included 62 women with POI and 62 age-matched controls. Women in both groups completed questionnaires. Pittsburgh Sleep Quality Index, Insomnia severity index, Epworth Sleepiness Scale, Hospital Anxiety and Depression Scale and Fatigue Severity Scale were used. Results We found poor sleep quality, higher levels of insomnia in women with POI than in controls. Depression was much more prevalent and severe in POI women. Total anxiety score, the severity of anxiety and fatigue did not differ significantly between the groups. According to the multivariable logistic regression analysis, being married and having POI were associated with worse quality of sleep, and having more children was associated with an increase in depression levels in the whole cohort. Backward analysis showed that when POI status was taken as a reference, married women were at 6.5 fold increased risk of poor sleep quality. Conclusions Women with premature ovarian failure are more likely to suffer from poor sleep quality, insomnia and depression than healthy women.
  • PublicationMetadata only
    The effect of serum progesterone level on ET Day and the efficacy of rescue progesterone treatment on ongoing pregnancy rates with artificial FET cycles
    (2022-07-01T00:00:00Z) ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; Okten, B.; Tanoglu, F. B.; İŞLEK, HAVVA SEVDE; PASİN, ÖZGE; Ficicioglu, C.; ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; İŞLEK, HAVVA SEVDE; PASİN, ÖZGE
  • PublicationMetadata only
    The importance of serum progesterone concentration at embryo transfer day and effect of rescue additional progesterone during programmed artificial frozen embryo transfer cycles
    (2022-01-01T00:00:00Z) ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; Okten, Berkem; TANOĞLU, FATMA BAŞAK; Taha, Havva Sevde; Pasin, Ozge; Ficicioglu, Cem; ÖZCAN, PINAR; ÇETİN, ÇAĞLAR; TANOĞLU, FATMA BAŞAK; PASİN, ÖZGE
    © 2022 Reproductive Healthcare Ltd.Research question: What is the efficacy and possible positive effect of additional rescue subcutaneous (s.c.) progesterone therapy for restoration of progesterone concentration on embryo transfer day and pregnancy rates during programmed artificial frozen embryo transfer (FET) cycles with vaginal progesterone tablet plus i.m. progesterone? Design: Multicentre prospective cohort study (NCT04769401) including a total of 238 programmed artificial FET between February 2021 and September 2021. Patients were divided into ≥10 ng/ml and <10 ng/ml according to serum progesterone concentrations on embryo transfer day; 25 mg of s.c. progesterone was added to patients with <10 ng/ml; blood samples were taken 2 days later. The primary outcome was the ongoing pregnancy rate. Results: The proportion of patients having ≥10 ng/ml serum progesterone concentrations on embryo transfer day was 70.7%. There was no statistically significant difference with regard to cumulative pregnancy rate, ongoing pregnancy rate and miscarriage between the groups (55.4% versus 61.5%, P = 0.4; 78.2% versus 72.5% per pregnancy, P = 0.5; 21.8% versus 27.5%, P = 0.5, respectively, ≥10 ng/ml and <10 ng/ml). Eighty-three per cent of patients with low serum progesterone concentrations on embryo transfer day reached an adequate progesterone concentration with rescue s.c. progesterone treatment; 90% of pregnancy rates in patients with serum progesterone concentrations <10 ng/ml on embryo transfer day were in patients who reached adequate serum progesterone concentrations with daily rescue s.c. progesterone treatment. Conclusions: The measurement of serum progesterone concentrations on embryo transfer day may create the opportunity for rescue progesterone administration on that day for patients who fail to reach adequate serum progesterone concentrations, achieving similar pregnancy rates without cancellation of the cycle.