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SELEK, ŞAHABETTİN

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ŞAHABETTİN
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SELEK
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Now showing 1 - 10 of 20
  • PublicationMetadata only
    Iron deficiency anemia and levels of oxidative stress induced by treatment modality
    (2013-06-01T00:00:00Z) Akarsu, Saadet; Demir, Hatice; Selek, ŞAHBETTİN; Oguzoncul, Ferdane; SELEK, ŞAHABETTİN
    Background The effects of iron deficiency anemia (IDA) and its treatment on plasma total antioxidant capacity (TAOC) were investigated. Methods Sixty patients with IDA and 20 healthy controls were divided into four subgroups: an oral (per os: PO) group (n = 20); an intramuscular (IM) group (n = 20); an intravenous (IV) group (n = 20); and the control group (n = 20). Blood samples were obtained from all patients before treatment, and at 24h, 7 days, 6 and 13 weeks after initiation of IDA therapy. Results TAOC in the IDA group was low when compared with the control group (P < 0.001). Although TAOC at 24h in the PO group was not different from the control group, the TAOC in the IM and IV groups was relatively lower (P < 0.001). The TAOC in the PO group at 7 days, and at 6 and 13 weeks was closest to the control group level. The mean TAOC in the IV group at 13 weeks was clearly lower relative to the PO and IM groups. Conclusions Oxidative stress was minimally induced with oral therapy, while IM and IV therapies induced higher levels of oxidative stress, in increasing order of intensity.
  • PublicationMetadata only
    An evaluation of Neuropeptide Y status in subacute sclerosing panencephalitis patients
    (2013-01-01T00:00:00Z) Abuhandan, M.; Calik, M.; Almaz, V.; Taskin, A.; Cakmak, A.; Selek, ŞAHBETTİN; SELEK, ŞAHABETTİN
    Aim. This study aimed to evaluate the neuropeptide Y values of patients with subacute sclerosing panencephalitis.
  • PublicationMetadata only
    Oxidative stress index may play a key role in patients with pemphigus vulgaris
    (2013-04-01T00:00:00Z) Yesilova, Y.; Ucmak, D.; Selek, ŞAHBETTİN; Dertlioglu, S. B.; Sula, B.; Bozkus, F.; Turan, E.; SELEK, ŞAHABETTİN
    Background Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, including atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus and alopecia areata. In PV, the increased production of ROS from activated neutrophils reduces the concentrations of antioxidant vitamins and enzymes. Objective The present study aims to determine the oxidative stress index (OSI) by studying serum total oxidant capacity (TOC), lipid hydroperoxide (LOOH) and total antioxidant capacity (TAC) in PV patients. Methods The study included 27 PV patients and a control group consisting of 24 healthy volunteers. Serum TOC, LOOH and TAC levels were examined and OSI was measured in the PV patients and the control group. Results TOC (P=0.001) and LOOH (P=0.001) levels as well as OSI (P=0.001) were found higher in the PV patients, relative to the control group. Serum TAS (P=0.221) did not differ between groups. Serum TOC, LOOH and TAC levels and OSI in PV patients with mucosal involvement were not different than those in mucocutaneous PV patients. Conclusion Serum TOC and LOOH levels and OSI were higher in the PV patients, in comparison with the control group. Serum TAC level was not different.
  • PublicationMetadata only
    Mononuclear leukocyte DNA damage and oxidative stress: The association with smoking of hand-rolled and filter-cigarettes
    (2011-04-03T00:00:00Z) Kocyigit, ABDÜRRAHİM; Selek, ŞAHBETTİN; Celik, Hakim; Dikilitas, Murat; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİN
    Cigarette smoking is a major cause of human cancer at various sites, although its carcinogenic mechanisms still remain unestablished. Based on the use of a filter, cigarette smoke can be divided into a gas phase and a tar phase. Both contain different concentrations of oxidants, free radicals and tobacco-specific carcinogens. To explore the effects of both filtered and non-filtered cigarette smoke on DNA damage and oxidative status, we measured the level of mononuclear leukocyte DNA damage by use of the single-cell gel electrophoresis (Comet) assay. We also determined malondialdehyde (MDA), protein carbonyl content (PC) and total antioxidative capacity (TAC) levels in blood plasma of smokers of manufactured filter-cigarettes and of hand-rolled cigarettes. Cotinine levels were also measured in plasma to estimate the degree of smoking. Mononuclear leukocyte DNA damage, plasma MDA, plasma PC and plasma cotinine levels were found significantly higher, while plasma TAC levels were found significantly lower in smokers of filter-cigarettes and smokers of hand-rolled cigarettes, compared with control subjects. TAC levels in hand-rolled and manufactured filter-cigarette smokers were not significantly different from each other. However, the levels of DNA damage. plasma MDA, plasma cotinine, and plasma protein oxidation were significantly higher in hand-rolled cigarette smokers than in filter-cigarette smokers. There was a significant positive correlation between MDA and DNA damage in both hand-rolled cigarette smokers and manufactured filter-cigarette smokers. This study indicates that smoking of hand-rolled cigarettes has stronger genotoxic and oxidative effects on the metabolism than smoking of manufactured filter-cigarettes. We propose that these harmful effects could be attributed to the higher level of oxidants. (C) 2011 Elsevier B.V. All rights reserved.
  • PublicationMetadata only
    Ferrous Sulfate (Fe2+) Had a Faster Effect Than Did Ferric Polymaltose (Fe3+) on Increased Oxidant Status in Children With Iron-deficiency Anemia
    (2014-01-01T00:00:00Z) Aycicek, Ali; KOÇ, AHMET; Oymak, Yesim; Selek, ŞAHBETTİN; Kaya, Cemil; Guzel, Bulent; SELEK, ŞAHABETTİN
    Objective: The purpose of this study was to compare the total oxidant and antioxidant effect of different oral iron preparations in children with iron-deficiency anemia (IDA).
  • PublicationMetadata only
    The effect of upper gastrointestinal system endoscopy process on serum oxidative stress levels.
    (2016-12-01) Turan, MN; Aslan, M; Bolukbas, FF; Bolukbas, C; Selek, ŞAHBETTİN; Sabuncu, T; SELEK, ŞAHABETTİN
  • PublicationMetadata only
    Paraoxonase (PON1) activity in patients with subclinical thoracic aortic atherosclerosis.
    (2014-06-01) GÜR, M; CAYLı, M; UÇAR, H; ELBASAN, Z; SAHIN, DAMLA; GÖZÜKARA, MY; Selek, ŞAHBETTİN; KOYUNSEVER, NY; ŞEKER, T; TÜRKOĞLU, C; KAYPAKLı, O; AKSOY, N; ŞAHİN, DAMLA; SELEK, ŞAHABETTİN
  • PublicationMetadata only
    Quantitative evaluation of dental anxiety indicators in the serum and saliva samples of children treated under general anesthesia
    (2018-07-01) Yıldırım, Sinem; Bakkal, MELTEM; Bulut, HURİ; Selek, ŞAHBETTİN; BAKKAL, MELTEM; BULUT, HURI; SELEK, ŞAHABETTİN
    Dental anxiety level has been previously associated with oral health status. Since general anesthesia (GA) allows dental treatments to be performed in anxious children with a high number of caries, we aimed to evaluate the dental anxiety levels of these children before and after dental treatments performed under GA.
  • PublicationMetadata only
    Therapeutic effects of Licorice (Glycyrrhiza glabra) on colitis through its antioxidant properties and biochemical analyses
    (2015-08-01) Uckaya, FATİH; Bektay, Yunus; Yilmaz, ANIL; Bayindir, NİHAN; Selek, ŞAHBETTİN; Topcu, GÜLAÇTI; Esrefoglu, MUKADDES; UÇKAYA, FATİH; BEKTAY, MUHAMMED YUNUS; YILMAZ, ANIL; BAYINDIR, NİHAN; SELEK, ŞAHABETTİN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES
  • PublicationMetadata only
    High morning blood pressure surge is associated with oxidative stress and paraoxonase 1 activity in newly diagnosed hypertensive patients.
    (2016-01-01) Kaypaklı, O; Gür, M; Harbalıoğlu, H; Şeker, T; Selek, ŞAHBETTİN; SELEK, ŞAHABETTİN