Person:
SELEK, ŞAHABETTİN

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ŞAHABETTİN
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SELEK
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Now showing 1 - 3 of 3
  • PublicationOpen Access
    Paraoxonase-1 Phenotype and Its Relationship with Mean Platelet Volume and Oxidative Stress in Coronary Artery Disease
    (2015-09-01) SELEK, ŞAHBETTİN ; ÖZER, ÖMER FARUK ; GOKTEKİN, Omer ; KOÇYİĞİT, ABDÜRRAHİM; KALINBACOGLU, Ceren; ISLEK, Irem ; ISLEK, Tuğba; ARPACI, Beyza; Erol, Neval; MEYDAN, Sedat; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; MEYDAN, SEDAT; GÜLER, ERAY METİN
    Objective: Paraoxonase-1 (PON1) 192 QR polymorphism is believed to be an important protective factor for coronary artery disease (CAD); oxidative stress plays a key role in the development of atherosclerotic CAD. Mean platelet volume (MPV) is also central to the processes, including pathophysiology of CAD and endothelial dysfunction. Thus, we aimed to determine the PON1 phenotype, MPV, and oxidative stress parameters in patients with angiographically proven CAD and to compare them with those in healthy subjects. Methods: Fifty-five CAD patients were diagnosed according to the angiography results, and 37 healthy subjects were present in this study. Serum paraoxonase and arylesterase activities were spectrophotometrically measured. Phenotype distribution was evaluated by the salt-stimulated paraoxonase activity according to arylesterase activity. Oxidative stress markers were evaluated by measuring serum total oxidant status (TOS) and total antioxidant status (TAS) as well as oxidative stress index. Results: In this study, the ratio of salt-stimulated paraoxonase/ OSI levels (S-PON1/OSI) were lower in the CAD patients and the differences were statistically significant (p<0.05). Therefore, the ratio of salt-stimulated paraoxonase/MPV (S -PON1/MPV) and S- PON1/OSI level were significantly different in the CAD patients as compared with controls group (p<0.01). Conclusion: Our study has suggested that S-PON1/OSI and SPON1/ MPV may play a significant role in CAD. To the best of our knowledge, the present study is the first to study the relationship among PON1 phenotype, MPV, and OSI in CAD patients. Thus, lowering of the oxidative stress and the regulation of MPV strategies may be a promising approach for the treatment of CAD.
  • PublicationOpen Access
    Phyotherapeutic Properties of Urfa Pistachio Nuts (Pistacia vera L.)
    (2018-07-01) Koyuncu, Ismail; KOÇYİĞİT, ABDÜRRAHİM; Dikme, Resat; SELEK, ŞAHBETTİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİN
    According to recent studies, the Urfa pistachio nut (Pistacia vera L.) is a rich source of phenolic components, with a high level of the three antioxidant substances of gallic acid, catechin, and epicatechin present together. The pistachio nut, which is in the top 50 foodstuffs with the highest antioxidant potential, is the only edible nut containing anthocyanin, which is the richest and has most variations of water and fat-soluble antioxidants. The pistachio nut also contains important bioactive polyphenol components, such as transreservatrol and isoflavones, which have anti-cancer potential. Some forms of the Pistachio species, including the Urfa pistachio nut, are used by the general population to improve the gastrointestinal, liver, urinary tract, and respiratory tract disorders and for various other purposes such as aphrodisiac, antiseptic, and antihypertensive effects. In some studies, it has been determined that the pistachio nut is beneficial in the continuation of mechanisms that provide maintenance of body health, such as anti-inflammatory activity, glycemic control, and endothelial functions, and it has also been shown to prevent the oxidation of low-density lipoprotein cholesterol and to have a protective role against chronic diseases such as cancer and cardiovascular disease. With a potassium content of 10.05 mg/gram, which is higher than other types of peanut, the sodium content of the pistachio nut may play a role in balancing the blood pressure by reducing the need for salt. This review is of importance in respect of the evaluation of the positive effect on several diseases of the kernel and particularly the shell extract of the pistachio nut.
  • PublicationOpen Access
    Exogenous Antioxidants are Double-edged Swords
    (2016-08-01) Kocyigit, ABDÜRRAHİM; SELEK, ŞAHBETTİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİN
    The balance between oxidation and antioxidation is believed to be critical in maintaining healthy biological systems. Under physiological conditions, the human antioxidative defense system, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione (GSH), allows the elimination of excess reactive oxygen species (ROS), including superoxide anions (O-2), hydroxyl radicals (OH), and alkoxyl radicals (RO). However, our endogenous antioxidant defense systems are incomplete without exogenously originating reducing compounds, such as vitamin C, vitamin E, carotenoids, and polyphenols, which play an essential role in many antioxidant mechanisms in living organisms. Therefore, there is continuous demand for exogenous antioxidants to prevent oxidative stress. However, higher doses of isolated compounds may be toxic, owing to pro-oxidative effects at high concentrations or their potential to react with beneficial concentrations of ROS normally present at physiological conditions that are required for optimal cellular functioning. In this review, synthetic antioxidants among supplementary antioxidants, fruit rich nutrition and various supplementary products to strengthen our body will be considered and discussed under the light of experimental and epidemiological evidence. Antioxidants in physiological dose ranges are considered to be safe in healthy people and overdoses cause damage via pro-oxidative effects; therefore, the importance of doses of antioxidants, the lower preventive doses that protect healthy individuals from illnesses, and higher therapeutic doses that treat cancer patients will be emphasized in this review.