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SELEK, ŞAHABETTİN

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ŞAHABETTİN
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SELEK
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Now showing 1 - 10 of 89
  • PublicationMetadata only
    Iron deficiency anemia and levels of oxidative stress induced by treatment modality
    (2013-06-01T00:00:00Z) Akarsu, Saadet; Demir, Hatice; Selek, ŞAHBETTİN; Oguzoncul, Ferdane; SELEK, ŞAHABETTİN
    Background The effects of iron deficiency anemia (IDA) and its treatment on plasma total antioxidant capacity (TAOC) were investigated. Methods Sixty patients with IDA and 20 healthy controls were divided into four subgroups: an oral (per os: PO) group (n = 20); an intramuscular (IM) group (n = 20); an intravenous (IV) group (n = 20); and the control group (n = 20). Blood samples were obtained from all patients before treatment, and at 24h, 7 days, 6 and 13 weeks after initiation of IDA therapy. Results TAOC in the IDA group was low when compared with the control group (P < 0.001). Although TAOC at 24h in the PO group was not different from the control group, the TAOC in the IM and IV groups was relatively lower (P < 0.001). The TAOC in the PO group at 7 days, and at 6 and 13 weeks was closest to the control group level. The mean TAOC in the IV group at 13 weeks was clearly lower relative to the PO and IM groups. Conclusions Oxidative stress was minimally induced with oral therapy, while IM and IV therapies induced higher levels of oxidative stress, in increasing order of intensity.
  • PublicationMetadata only
    Molecular cloning and characterization of NAD(+) dependent isocitrate dehydrogenase enzyme from Shewanella putrefaciens
    (2021-10-01T00:00:00Z) Fahri, Akbas; Metin, Demirel; Ahmet, Ozaydin; Sahabettin, ŞAHBETTİN; AKBAŞ, FAHRİ; DEMİREL, METİN; SELEK, ŞAHABETTİN
    Isocitrate dehydrogenase (IDH) is a fundamental enzyme for carbon metabolism in the Krebs cycle. This enzyme is required for oxidation-reduction reactions in both eukaryotic and prokaryotic cells and plays a critical role in their growth and pathogenesis. In this study, we cloned the gene encoding NAD(+) dependent isocitrate dehydrogenase from Shewanella putrefaciens. The expression of recombinant protein was induced with 0.5 mM of IPTG. His-tagged IDH overexpressed in E. coli was purified and characterized. The expressed IDH enzyme was purified in an active soluble form. The molecular weight of the enzyme was confirmed with Western blotting. High sequence homology was observed with IDH sequences of other Shewanella strains and remarkable sequence homology was found with other bacteria reported in the database.
  • PublicationMetadata only
    Gamma glutamyl transferase activity is Independently associated with oxidative stress rather than SYNTAX score
    (2015-01-01) UCAR, Hakan; GUR, Mustafa; GOZUKARA, Mehmet Yavuz; KALKAN, Gulhan Yuksel; BAYKAN, Ahmet Oytun; TURKOGLU, Caner; KAYPAKLI, Onur; SEKER, Taner; SEN, Omer; Selek, Sahbettin; CAYLI, Murat; SELEK, ŞAHABETTİN
    Background. Gamma glutamyl transferase (GGT) is involved in the pathophysiologic process of coronary atherosclerosis. GGT activity plays a role in the catabolism of glutathione which is known as one of the major antioxidants. However, there is a lack of research on direct examination of relevance between serum GGT activity with systemic oxidative stress. Objectives. We aimed to investigate the relationship between GGT activity with systemic oxidative stress markers and the extent and complexity of coronary artery disease (CAD) assessed with SYNTAX score in stable CAD. Methods. Measurements were obtained from 359 patients with stable CAD (Mean age = 57.7 +/- 10.1 years). The patients were divided into two groups according to the median GGT level (GGT median group > 22). Angiography was performed and SYNTAX score was calculated in all patients. Oxidative stress markers (total oxidant status [TOS], total antioxidant capacity [TAC] and oxidative stress index [OSI]) were measured in all patients. Results. While SYNTAX score and oxidative stress markers such as TOS and OSI have been increased, TAC was decreased in GGT > median group compared with GGT < median group (p < 0.05, for all). GGT activity was independently associated with diabetes (beta = 0.106, p = 0.015) and OSI (beta = 0.556, p < 0.001) in multiple linear regression analysis. However, the independent association between GGT activity and SYNTAX score was not found in present study (beta = 0.063, p = 0.238). Conclusion. In stable CAD, increased GGT activity within the normal range is associated with increased oxidative stress rather than increased extent and complexity of CAD.
  • PublicationMetadata only
    An evaluation of Neuropeptide Y status in subacute sclerosing panencephalitis patients
    (2013-01-01T00:00:00Z) Abuhandan, M.; Calik, M.; Almaz, V.; Taskin, A.; Cakmak, A.; Selek, ŞAHBETTİN; SELEK, ŞAHABETTİN
    Aim. This study aimed to evaluate the neuropeptide Y values of patients with subacute sclerosing panencephalitis.
  • PublicationMetadata only
    Serum paraoxonase enzyme activity and oxidative stress in obese subjects
    (2011-01-01T00:00:00Z) ASLAN, Mehmet; Horoz, Mehmet; Sabuncu, Tevfik; Celik, Hakim; Selek, Sahbettin; SELEK, ŞAHABETTİN
    Introduction Obesity is an important risk factor for atherosclerotic cardiovascular disease. Paraoxonase-1 (PON1) may play a significant role in the prevention of obesity-related accelerated atherosclerosis by hydrolyzing lipid peroxides in oxidized low-density lipoproteins.
  • PublicationMetadata only
    MicroRNA expressions are altered in endometrial tissues of PCOS women
    (2017-09-01) BULUT, HURİ; BULUT, Berk; SERDARZADE, A.; Yuksel, B.; Selek, S.; BULUT, HURI; SELEK, ŞAHABETTİN
  • PublicationMetadata only
    Hipotroidili hastalarda paraoxonase aktivitesinin ölçülmesi ve ateroskleroz ile ilişkisinin araştırılması
    (2018-05-11T00:00:00Z) ÇELİK, HAKİM; Aksoy, Nurten; SELEK, ŞAHBETTİN; EREL, ÖZCAN; SELEK, ŞAHABETTİN
  • PublicationMetadata only
    Farelede Radyoterapinin Etkileri
    (2015-04-27T00:00:00Z) TAŞPINAR, ÖZGÜR; AYDIN, TEOMAN; KILIÇ, GÖKHAN; EREN, FATMA; KIZILTAN, HURİYE; KEPEKÇİ, MÜGE; ERİŞ, HİKMET; KESKİN, YAŞAR; ÖZER, ÖMER FARUK; SELEK, ŞAHBETTİN; SEYİTHANOĞLU, MEHMET HAKAN; AYDIN, TEOMAN; KILIC, GÖKHAN; KESKİN, YAŞAR; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİN
  • PublicationMetadata only
    Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.
    (2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİL
  • PublicationMetadata only
    Investigation of Oxidative Stress Markers in the Pathogenesis of the Lung, Breast and Colon Cancer
    (2017-09-23T00:00:00Z) ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHBETTİN; ÇOBAN, GANİME; TÜRK, HACI MEHMET; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİN; ÇOBAN, GANİME; TÜRK, HACI MEHMET