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Now showing 1 - 10 of 25
  • PublicationMetadata only
    Role of Serum and Biliary CEA, CA19-9, VEGFR-3 and TAC for Differentation of Malignant and Benign Biliary Obstruction
    (2014-05-01) Ince, ALİ TÜZÜN; YILDIZ, Kemal; BAYSAL, Birol; DANALIOGLU, Ahmet; KOCAMAN, Orhan; TOZLU, Mukaddes; GANGARAPU, Venkatanarayana; KEMIK, Ahu Sarbay; UYSAL, Oemer; Senturk, HAKAN; İNCE, ALİ TÜZÜN; UYSAL, ÖMER; ŞENTÜRK, HAKAN
  • PublicationMetadata only
    A randomized controlled trial of home monitoring versus hospitalization for mild non-alcoholic acute interstitial pancreatitis: A pilot study
    (2014-05-01) Ince, ALİ TÜZÜN; Senturk, HAKAN; Singh, Vikesh K.; YILDIZ, Kemal; DANALIOGLU, Ahmet; CINAR, Ahmet; Uysal, Omer; KOCAMAN, Orhan; BAYSAL, Birol; Guerakar, Ahmet; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMER
    Background/Objectives: Acute pancreatitis (AP) is a disease typically requiring in-hospital treatment. We conducted a trial to assess the feasibility of early discharge from the hospital for patients with mild nonalcoholic acute pancreatitis (NAAP).
  • PublicationMetadata only
    Efficacy of Rifaximin on Circulating Endotoxins and Cytokines in Patients With Non-Alcoholic Fatty Liver
    (2015-04-01) Gangarapu, Venkatanarayana; Ince, Ali T.; BAYSAL, Birol; KAYAR, Yusuf; Senturk, HAKAN; KILIC, Ulkan; GOK, Ozlem; Uysal, Oemer; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMER
  • PublicationOpen Access
    Comparison of tomographic and colonoscopic diagnoses in the presence of colonic wall thickening
    (2014-01-01) Ince, ALİ TÜZÜN; BAYSAL, Birol; KAYAR, Yusuf; Arabaci, ELİF; Bilgin, MEHMET; HAMDARD, Jamshid; YAY, Adnan; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ARABACI, ELİF; BİLGİN, MEHMET; ŞENTÜRK, HAKAN
    Introduction and objective: Colonic wall thickening is a common condition in a number of benignant and malignant diseases. This study investigated the accuracy of radiological diagnoses in patients diagnosed with colonic wall thickening using multislice CT (MDCT). Materials and method: Files of patients with colonic wall thickening diagnosed with 64-slice MDCT were reviewed retrospectively. The colonoscopy results of these patients were grouped under neoplastic process (cancer and adenomatous polyp), inflammatory bowel disease (IBD), diverticulitis and other etiology (nonspecific events, ischemic colitis, solitary rectal ulcer, external compression, secondary to volvulus and radiotherapy), and the results were statistically evaluated. p values < 0.05 were considered statistically significant. Results: The study was performed on 505 files (290 males [57.4%], 215 females [42.6%], mean age: 49.15 ± 18.4 years). CT and colonoscopic diagnoses were reviewed and the following CT to colonoscopy ratios was observed: neoplastic process: 44.4% vs. 40.2%; IBD: 42.4% vs. 42.4%; diverticulitis: 4% vs. 4.2%; other etiology: 9.3% vs. 3.2%. Colonoscopy failed to identify pathology in 9.9% of the patients. The sensitivity, specificity, PPV, NPV and accuracy of CT were 95.6%, 90.4%, 87.1%, 96.8% and 92.4%, respectively, in detecting neoplastic processes; 97.2%, 97.9%, 97.2%, 97.9% and 97.6%, respectively, in detecting IBD; 90.5%, 99.8%, 95%, 99.6% and 99.4%, respectively, in detecting diverticulitis, and 50%, 96,7%, 62.5%, 94.6% and 92%, respectively, in detecting other etiology. Conclusion: While, accuracy of 64 slice-CT in diagnosing colonic wall thickenings secondary especially to neoplastic processes, IBD and diverticulitis was significantly higher, but differential diagnosis is challenging in pathologies due to other etiologies.
  • PublicationOpen Access
    Role of gut microbiota: Obesity and NAFLD
    (2014-04-01) GANGARAPU, Venkatanarayana; YILDIZ, Kemal; Ince, ALİ TÜZÜN; BAYSAL, Birol; İNCE, ALİ TÜZÜN
    Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD.
  • PublicationMetadata only
    Low Molecular Weight Heparin Treatment of Acute Severe Pancreatitis: A Randomized, Controlled Study
    (2015-04-01) TOZLU, Mukaddes; KAYAR, Yusuf; BAYSAL, Birol; Ince, ALİ TÜZÜN; KOCAMAN, Orhan; DANALIOGLU, Ahmet; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
  • PublicationMetadata only
    Helicobacter pylori is undetectable in intraductal papillary mucinous neoplasm
    (2016-09-01) BAYSAL, Birol; Ince, ALİ TÜZÜN; Gucin, ZÜHAL; Malya, FATMA ÜMİT; TOZLU, Mukaddes; Senturk, HAKAN; BAĞCI, PELİN; Celikel, Cigdem Ataizi; Gultepe, Bilge; OZKARA, Selvinaz; PASAOGLU, Esra; DURSUN, Nevra; OZGUVEN, Banu Yilmaz; TUNCEL, Deniz; İNCE, ALİ TÜZÜN; SÜMBÜL, BİLGE; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİT; ŞENTÜRK, HAKAN
    Background: About half of the world population is infected with Helicobacter pylori (H. pylori), a bacterium associated with gastric cancer and considered to be a risk factor for pancreatic ductal adenocarcinoma. Whether the bacterium is associated with intraductal papillary mucinous neoplasm, believed to be a precursor of pancreatic ductal adenocarcinoma, is unknown. The aim of this study was to investigate the presence of H. pylori DNA in tissue sections of intraductal papillary mucinous neoplasm.
  • PublicationOpen Access
    Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma
    (2015-01-01) Ince, ALİ TÜZÜN; YILDIZ, Kemal; GANGARAPU, Venkatanarayana; KAYAR, Yusuf; BAYSAL, Birol; KARATEPE, Oguzhan; Kemik, Ahu Sarbay; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN
    Aim: Cholangiocarcinoma is generally detected late in the course of disease, and current diagnostic techniques often fail to differentiate benign from malignant disease. Ongoing biomarker studies for early diagnosis of cholangiocarcinoma are still continues. By this study, we analyzed the roles of serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma. Materials and methods: The 113 patients (55 males, 58 females) were included; 33 diagnosed with cholangiocarcinoma (malignant group) and 80 diagnosed with choledocholithiasis (benign group). MMP-9 and TIMP-1 concentrations were analyzed in serum and bile and compared in the malignant and benign groups. Results were evaluated statistically. Results: Biliary MMP-9 concentrations were significantly higher (576 ± 209 vs. 403 ± 140 ng/ml, p < 0.01) and biliary TIMP-1 concentrations were significantly lower (22.4 ± 4.9 vs. 29.4 ± 6.1 ng/ml, p < 0.01) in the malignant than in the benign group. In contrast, serum MMP-9 and TIMP-1 concentrations were similar in the two groups. Receiver operating curve analysis revealed that the areas under the curve of bile MMP-9 and TIMP-1 were significantly higher than 0.5 (p < 0.001). The sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and accuracy were 0.94, 0.32, 0.36, 0.93, 1.40, 0.19 and 0.5 for biliary MMP-9, respectively, and 0.97, 0.36, 0.39, 0.97, 1.5, 0.08 and 0.54 for biliary TIMP-1, respectively. Conclusion: Serum and biliary MMP-9 and TIMP-1 tests do not appear to be useful in the diagnosis of cholangiocarcinoma.
  • PublicationMetadata only
    The Role of EUS Examination and EUS-Guided Fine Needle Aspiration Biopsy for Evaluation of Gastric Subepithelial Lesions: a Large Single Center Experience
    (2015-05-01) BAYSAL, Birol; MASRI, Omar; DANALIOGLU, Ahmet; ILBAK, Ayca; KAYAR, Yusuf; Ince, ALİ TÜZÜN; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN