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DESTEK, SABAHATTİN

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SABAHATTİN
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DESTEK
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Now showing 1 - 10 of 23
  • PublicationOpen Access
    Using pentraxin-3 for diagnosing acute appendicitis and predicting perforation: A prospective comparative methodological study.
    (2020-01-01T00:00:00Z) Gul, VO; Destek, SABAHATTİN; DESTEK, SABAHATTİN
    BACKGROUND: In this study, we aimed to investigate the diagnostic performance of pentraxin-3 for acute appendicitis, and the predictive performance for perforation in patients with acute appendicitis, compared with white blood cell count, high-sensitivity C-reactive protein and interleukin-6 (IL-6). METHODS: This study was a prospective methodological study, in which we studied the accuracies of the serum levels of pentraxin-3, white blood cell count, interleukin-6 and high-sensitivity C-reactive protein in estimating acute appendicitis, and in estimating perforation in patients with acute appendicitis. We designed the control group with the patients diagnosed inguinal hernia and admitted for elective surgery. Receiver operating characteristics analysis was used to compare the diagnostic accuracies and predictive performances. RESULTS: Receiver operating characteristics analysis revealed that the Pentraxin-3 level >3.67 ng/mL showed the sensitivity of 95.5% and specificity of 100.0% for diagnosing acute appendicitis, with an area under the curve of 0.993 (95% CI 0.967–1.000). Also, the Pentraxin-3 level >9.56 ng/mL showed the sensitivity of 92.9%, and the specificity of 87.1% for the prediction of the perforation, with an area under the curve of 0.820 (95% CI 0.736–0.886). CONCLUSION: The diagnostic performance of Pentraxin-3 for acute appendicitis and the predictive performance for perforation were higher than white blood cell count, high-sensitivity C-reactive protein and interleukin-6.
  • PublicationMetadata only
    Effectiveness of conservative approach in right colon diverticulitis
    (2019-07-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİN
    BACKGROUND: Approximately 10%-25% of patients with colon diverticular disease experience colonic diverticulitis during their lives. Right-sided diverticulosis is a rare condition in Western countries, but it is common among Asian countries. The aim of this study was to evaluate the clinical and treatment outcomes in our patients with right colon diverticulitis.
  • PublicationMetadata only
    Diffuse idiopathic necrobiosis lipoidica: case report
    (2018-01-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; Ahioglu, Serkan; DESTEK, SABAHATTİN
    Necrobiosis lipoidica is a granulomatous skin disease whose etiology and pathogenesis are not fully explained. The association of necrobiosis lipoidica with diabetes mellitus is frequently discussed and it is thought that microangiopathy plays an important role. Although there are many treatment options, there is no standard treatment model. In this study; a 43-year-old female patient with common skin lesions and punch biopsy and necrobiosis lipoidica diagnosis was presented. The patient was found to have concomitant diabetes mellitus with necrobiosis lipoidica. After treatment, diabetes mellitus clinic resolves but the necrobiosis lipoidica does not fully recover; Autoimmune hepatitis was detected and immunosuppressive treatment was given and the patient-s treatment was provided. In this case report, etiology and treatment of necrobiosis lipoidica have been discussed based on this case.
  • PublicationMetadata only
    Mide Kanserleri
    (2019-05-01T00:00:00Z) Akçakaya, Adem; Destek, Sabahattin; AKÇAKAYA, ADEM; DESTEK, SABAHATTİN
    Mide kanseri tedavisin de etkin yöntem radikal cerrahidir. D2 lenf nodu diseksiyonu (LND) ile gastrektomi standart tedavidir. Erken evre mide kanserlerinde (Evre IA) endoskopik tedavi yapılabilir. Evre IB-II-IIIA mide kanserlerinde radikal cerrahi yapılır. R0 rezeksiyon sağlamak ana hedeftir. Evre IIIB-IV gibi lokal ileri mide kanserlerinde genişletilmiş rezeksiyonla beraber D2 LND yapılabilir. Bu durumda cerrahi palyatif kalabilmekte ve prognoz üstüne etkisi olmamaktadır. Bursektominin surviye katkısı net olarak gösterilmemiştir. Rutin LND-nin bir parçası olarak splenektomi büyük ölçüde terk edilmiştir. Minimal invaziv cerrahi için genel olarak kabul edilen endikasyon erken mide kanserleridir. Laparoskopik ve Robotik yöntemlerle mide kanserinin cerrahi tedavisi gün geçtikçe artmaktadır. Tümörün lokalizasyonu, yaygınlığı, merkez ve cerrahın tecrübesine göre tercih edilme oranı değişmektedir. Radikal cerrahiye rağmen, ileri evre mide kanseri için uzun dönem sonuçları tatmin edici değildir. Tanı amaçlı laparoskopi ameliyat öncesi akılda tutulmalıdır. Neoadjuvan tedavi özellikle ileri evre kanserlerde önerilmektedir. Adjuvan kemoradyoterapi cerrahinin tamamlayıcısı olarak yerini korumaktadır.
  • PublicationMetadata only
    A Rare Disease of the Digestive Tract: Esophageal Melanosis
    (2016-06-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; Ahioglu, Serkan; Erbil, Yesim; DESTEK, SABAHATTİN
    Esophageal melanosis which is characterized by melanocytic proliferation in the squamous epithelium of the esophagus and melanin accumulatin of esophageal mucosa (EM) is a rare disease of the digestive system. Although esophageal melanosis is considered to be a benign disease, its etiology is not cleared and has been reported to be the precursor lesion of esophageal primary melanomas. In this report, we aimed to note esophageal melanosis in a 55-year-old female case who applied to our clinic with difficulty in swallowing, burning behind the breastbone in the stomach, heartburn, indigestion, and pain in the upper abdomen after endoscopic and pathologic evaluation. Complaints dropped with anti-acid therapy and case was followed by intermittent endoscopic procedures because of precursor melanocytic lesions.
  • PublicationMetadata only
    Minimally Invasive Surgical Approach to Complicated Recurrent Pilonidal Sinus
    (2015-01-01T00:00:00Z) Gul, Vahit Onur; Destek, SABAHATTİN; Ozer, Serhat; Etkin, Ergin; Ahioglu, Serkan; Ince, Mehmet; Cimin, Vedat; Sen, Deniz; Erbil, Yesim; DESTEK, SABAHATTİN
    Pilonidal sinus is considered as a simple and frequently occurring disease localized at the sacrococcygeal area. However, at the intergluteal region, it can often turn into a chronic and complicated disease. In some cases, it can fistulize up to the gluteal region and appear at the secondary orifices. Minimally invasive surgical techniques are becoming widespread in recent years due to the increased experience and development of new instruments. Limited excision of the pilonidal sinus tract can be a better treatment option compared with large excisions in terms of recovery time and patient-s comfort. This case study reports the singlephase surgical treatment of complicated and recurrent pilonidal sinus localized at the gluteal area, with minimal tissue loss and inflammation.
  • PublicationOpen Access
    Pituitary Adenoma and Hyperprolactinemia Accompanied by Idiopathic Granulomatous Mastitis.
    (2017-01-01T00:00:00Z) Destek, SABAHATTİN; GUL, VO; AHIOGLU, S; SERIN, KR; DESTEK, SABAHATTİN
  • PublicationMetadata only
    Fibroepitelyal Anal Polipler Ve Eşlik Eden Anal Hastalıklar
    (2019-10-01T00:00:00Z) Destek, Sabahattin; DESTEK, SABAHATTİN
  • PublicationMetadata only
    Hereditary Thrombophilia Risk Factors In Patients With Venous Thromboembolism
    (2020-01-01T00:00:00Z) Destek, Sabahattin; Gül, Vahit Onur; DESTEK, SABAHATTİN
    Venous thromboembolic disease (VTD) is a serious cause of mortality and morbidity with an incidence of 0.1% per year. The etiology of VTD is multifactorial and associated with acquired and hereditary conditions. The aim of our study was to investigate the presence of rare genetic mutations in VTD patients and to evaluate their distribution according to thrombosis sites.The study group consisted of 107 patients who underwent genetic testing for thrombophilia due to VTD between 2015 and 2017. Patients with VTD who underwent thrombophilic genetic examination by polymerase chain reaction method were included in the study. Antithrombin III, protein C and protein S deficiency patients diagnosed with biochemical tests were excluded from the study. The demographic characteristics and clinical results of the patients were obtained from the hospital archive. The control group consisted of 112 healthy individuals randomly selected from the community. The patient group and the control group were compared.The mean age of the patients was 39.6 years. The female/male ratio was 1.7. Advanced age and female gender were statistically significantly more frequent in the patient group (In both, p=0.0001). Factor V G1691A and B-Fibrinogen-455 genetic defects were statistically significantly higher in the patient group (Respectively; p=0.008, p=0.049). The most frequent (54.2%) PAI-4G&5G heterozygous gene defect was found in the patients. Deep venous thrombosis was detected in 54.2%, intraabdominal VTD in 4.7%, pulmonary embolism in 27.1%, and cerebral venous thrombosis in 30.8% of the VTD patients.Thrombophilic genetic mutations are not uncommon in patients with VTD. Thrombophilic genetic mutations in VTD etiology and in selected patients should be investigated. In patients without known thrombophilia mutations, rare thrombophilic mutations should be examined.
  • PublicationMetadata only
    A variety of gene polymorphisms associated with idiopathic granulomatous mastitis
    (2016-09-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; Ahioglu, Serkan; DESTEK, SABAHATTİN
    Idiopathic granulomatous mastitis (IGM) is a rare and chronic inflammatory disorder. IGM mimics breast cancer regarding its clinical and radiological features. Etiology of IGM remains unclarified. Our patient was 37-year-old and 14 weeks pregnant. There was pain, redness and swelling in the right breast. The mass suggestive of malignancy was detected in sonography. Serum CA 125 and CA 15-3 levels were high. Genetic analysis was performed for the etiology. methylenetetrahydrofolate reductase (MTHFR) C 677 TT, beta-fibrinogen-455 G>A, plasminogen activator inhibitor (PAI)-1 5 G/5 G, angiotensin-converting enzyme (ACE) I/D mutation was found. IGM was diagnosed by cor biopsy. An association was also reported between breast cancer and mutations in MTHFR-C 677 T, PAI-1, ACE genes. Genetic polymorphisms may involve in the development of IGM as it was seen in our case. Further studies should be conducted to better clarify this plausible association.