Person: GÖKMEN KARASU, AYŞE FİLİZ
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Publication Open Access Chronotype anc Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome(2021-01-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; Sahbaz, Cigdem Dilek; Dogu, Zeynep Filiz Eren; TAKMAZ, TAHA; ÇALI, HALİME; Tanoglu, Basak; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHBAZ, ÇIĞDEM DILEK; TAKMAZ, TAHA; ÇALI, HALİMEAim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients.Publication Open Access Association of intrinsic sphincter deficiency with urine flow acceleration measurement(2020-09-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; Aydin, Serdar; KALKAN, Senad; ERSÖZ, CEVPER; GÖKMEN KARASU, AYŞE FİLİZ; KALKAN, SENAD; ERSÖZ, CEVPERBackground Intrinsic sphincter deficiency (ISD) is associated with an inability to maintain mucosal coaptation either at rest or in the presence of stress resulting from damage to muscles or nerves that maintain tonus. The purpose of our trial was to determine the role of urodynamic measurements of flow such as maximum flow rate, flow time, and acceleration speed of flow to assess the urethral resistance on prediction of stress incontinence and ISD. Materials and Methods Our study was based on a retrospective analysis of urodynamic records of female patients performed for urinary incontinence. Mean flow rate, maximum flow rate, detrusor pressure at maximum flow, vesical pressure at maximum flow, maximum detrusor pressure, and flow rate at maximum detrusor pressure measurements were extracted from the voiding phase of urodynamic charts. The slope of the maximum flow was used to calculate acceleration of flow (Qacc). The urodynamic records of 142 women were reviewed and Qacc was measured. Results The mean age of the ISD group was 53.3 +/- 12.5 (24-78) and of the non-ISD group 53.7 +/- 12.5 (35-74). The mean Qacc (30.3 +/- 16.1 degrees [mL/s(2)]) in the ISD group was significantly higher than in the non-ISD group (21.6 +/- 9.6 degrees [mL/s(2)]). Urodynamic bladder capacity of the non-ISD group (432.3 +/- 90.4 mL) was higher than the ISD group (389.2 +/- 109) (P = .01). Conclusion The Valsalva leak point pressure and maximum urethral closure pressure measurements in assessing urethral function are not useful for predicting incontinence surgery failure. We demonstrated that Qacc is higher in ISD stress incontinent women than stress incontinent women. Qacc may demonstrate urethral resistance and tonus in a more reliable manner.Publication Open Access Utilization of Wilms- tumor 1 antigen in a panel for differential diagnosis of ovarian carcinomas(2016-03-01) Sen, Dilek Sakirahmet; Karasu, AYŞE FİLİZ; Gecer, Melin Ozgun; KARADAYI, Nimet; Yamuc, Elif Ablan; GÖKMEN KARASU, AYŞE FİLİZObjective: Ovarian metasteses are often mistaken for primary adenocarcinoma. Studies conducted in recent years have focused on a search for an immunohistochemical marker to aid the differential diagnosis primary and metastatic ovarian carcinoma. Our study objective was to study the usefulness of Wilms tumor 1 (WT 1) antigen in this context. Materials and methods: The study was conducted at the pathology clinic of Lütfi Kırdar Training and Research Hospital. Deparaffinated blocks of 40 epithelial ovarian tumors, 40 colon adenocarcinomas, and 35 cases of omentum metastases were studied. Cytokeratin 7 (CK 7), cytokeratin 20 (CK 20), and WT 1 were applied to all specimens. Results: All ovarian adenocarcinomas were stained with CK 7 (100%). Colorectal adenocarcinomas were stained positive with CK 20 in 87.5% of cases. Primary ovarian adenocarcinomas stained positive with WT 1 in 82.5% of the cases and none of the colorectal adenocarcinomas showed staining with WT 1 (0%). Conclusion: WT 1 can be used in conjuction with CK 7 in the differential diagnosis of ovarian carcinomas.