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TOPRAK, HÜSEYİN

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HÜSEYİN
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TOPRAK
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Now showing 1 - 10 of 75
  • PublicationMetadata only
    Relationship between KRAS mutation and diffusion weighted imaging in colorectal liver metastases; Preliminary study.
    (2020-02-25T00:00:00Z) Türk, HM; Gültekin, MEHMET ALİ; Uysal, Ö; Beşiroğlu, M; Yilmaz, TF; Yurtsever, I; GÜLTEKİN, MEHMET ALİ; TÜRK, HACI MEHMET; TOPRAK, HÜSEYİN; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; SHARIFOV, RASUL; UYSAL, ÖMER
    Purpose: We aimed to investigate whether there are any differences in apparent diffusion coefficient (ADC) values obtained from colorectal liver metastases (CRLM) according to Kirsten rat sarcoma (KRAS) gene mutation status.
  • PublicationOpen Access
    Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in the evaluation of the biliary obstruction
    (2012-01-01) BALCI, CEM NUMAN; Bilgin, MEHMET; Toprak, HÜSEYİN; BURGAZLI, MEHMET; BILGIN, SABRİYE ŞENNUR; CHASAN, RITVAN; ERDOĞAN, ALİ; BİLGİN, MEHMET; TOPRAK, HÜSEYİN
    Purpose: In this study, our purpose was to investigate the diagnostic efficacy of the dynamic contrast-enhanced magnetic resonance imaging (MRI) method in the patients with bile duct obstruction. Materials and methods: 108 consecutive patients (53 men, 55 women, mean age; 55.77 ± 14.62, range 18-86 years) were included in this study. All the patients underwent conventional upper abdomen MRI using intravenous contrast material (Gd-DTPA) and MRCP in 1.5 Tesla MRI scanner. MRCP images were evaluated together with the T1 and T2w images, and both biliary ducts and surrounding tissues were examined for possible pathologies that may cause obstruction. Results: MRI/MRCP findings compared with final diagnoses, MRI/MRCP in the demonstration of bile duct obstruction sensitivity 96%, the specificity 100%, and accuracy 96.3%, in the detection of presence and level of obstruction, the sensitivity 96.7%, specificity 100%, and accuracy 97.2%, in the diagnosis of choledocholithiasis, the sensitivity 82.3%, specificity 96%, and accuracy 91.7%, and in the determination of the character of the stenosis, sensitivity 95.6%, specificity 91.3%, and accuracy 94.5% were found. Conclusion: The combination of dynamic contrast-enhanced MRI and MRCP techniques in patients with suspected biliary obstruction gives the detailed information about the presence of obstruction, location, and causes and is a highly specific and sensitive method.
  • PublicationOpen Access
    MRI and MR Spectroscopy Features of Heat Stroke: A Case Report
    (2018-07-01) Yilmaz, TEMEL FATİH; Aralasmak, AYŞE; Toprak, HÜSEYİN; GULER, Serhat; Tüzün, Umit; Alkan, ALPAY; YILMAZ, TEMEL FATİH; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; ALKAN, ALPAY
    Heat stroke is the outcome of over heat stress that results in multiorgan dysfunction with a tendency for central nervous system damage. Brain is very sensitive to hyperthermia, especially the cerebellum that has selective vulnerability to heat stroke. There is complex interaction between heat cytotoxicity, coagulation disorder, cytotoxine - mediated systemic inflammatory response causing multiorgan failure, metabolic derangement, and circulatory insufficiency. We reviewed the literature and discussed brain MRI and MR spectroscopy findings of heat stroke, detailed the pathophysiology underlying brain involvement and proposed excitotoxic injury as an alternative mechanism of brain damage in heat stroke.
  • PublicationMetadata only
    Role of F-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in diagnosis and management of pancreatic cancer; comparison with Multidetector Row Computed Tomography, Magnetic Resonance Imaging and Endoscopic Ultrasonography
    (2014-05-01) ERGUL, N.; GUNDOGAN, C.; TOZLU, M.; TOPRAK, HÜSEYİN; KADIOGLU, HÜSEYİN; Aydin, MEHMET; CERMIK, T. F.; TOPRAK, HÜSEYİN; KADIOĞLU, HÜSEYİN; AYDIN, MEHMET
    Objectives: We aimed to analyze the contribution of F-18-fluorodeoxyglucosepositron emission tomography/computed tomography (FDG PET/CT) imaging to the diagnosis and management of pancreatic cancer compared with multidetector row computed tomography (MDCT), magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS).
  • PublicationMetadata only
    Papillary Lesions of the Breast: Addition of DWI and TIRM Sequences to Routine Breast MRI Could Help in Differentiation Benign from Malignant
    (2022-01-01T00:00:00Z) GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; YILMAZ, TEMEL FATİH; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMA; GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; YILMAZ, TEMEL FATİH; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMA
    Aim: We aimed to investigate the magnetic resonance imaging (MRI) features of benign, atypical, or malignant papillary breast lesions and to assess the additional value of diffusion-weighted imaging (DWI) and turbo inversion recovery magnitude (TIRM) sequences to routine breast MRI. Background: Differentiation between benign and malignant papillary breast lesions is essential for patient management. However, morphologic features and enhancement patterns of malignant papillary lesions may overlap with those of benign papilloma. Methods: Seventy-two papillary breast lesions (50 benign, 22 atypical or malignant) were included in the current study, retrospectively. We divided the patients into two groups: benign papillary breast lesions and atypical or malignant papillary breast lesions. Morphologic, dynamic, turbo inversion recovery magnitude (TIRM) values and diffusion features of the papillary lesions were compared between two groups. Results: Benign papillary lesions were smaller in size (p=0.006 and p=0.005, for radiologists 1 and 2 respectively), closer to the areola (p=0.045 and 0.049 for radiologist 1 and 2 respectively), and had higher ADC values (p=0.001 for two radiologists) than the atypical or malignant group. ROC curves showed diagnostic accuracy for ADC (AUC=0.770 and 0.762, p & lt; 0.0001 for two radiologists), and showed a cut-off value of <= 957 x 10-6 mm(2/s) (radiologist 1) and <= 910 x 10-6 mm(2/s) (radiologist 2). Conclusion: MRI is a useful method for differentiation between benign and malignant papillary breast lesions. Centrally located, lesser in size, and higher ADC values should be considered benign, whereas peripherally located, larger in size, and lower ADC values should be considered malignant.
  • PublicationOpen Access
    Comparison of MRI Features of Invasive Pleomorphic and Classical Lobular Carcinoma: Differentiation Is Possible?
    (2022-01-01T00:00:00Z) YILMAZ, TEMEL FATİH; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; GÜCİN, ZÜHAL; GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMA; YILMAZ, TEMEL FATİH; OTÇU TEMUR, HAFİZE; SARI, LÜTFULLAH; GÜCİN, ZÜHAL; GÜLTEKİN, MEHMET ALİ; ÇELİK YABUL, FATMA; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMA
    To evaluate breast MRI and DWI and demographic features of pleomorphic invasive lobular carcinoma (pILC) and classic invasive lobular carcinoma (cILC). Invasive lobular (ILC) is the second most common breast malignancy after invasive ductal carcinoma (IDC) and constitutes the 8-14% of all invasive breast cancers. ILC morphologically can be classified into the classic, alveolar, solid, tubulolobular, and pleomorphic subtypes according to WHO. This study was performed retrospectively. The MRI and demographic features of 18 patients with 23 pILC were compared with those 22 consecutive patients with 27 cILC. There was no significant difference in demographic features of patients, MR appearance, kinetics, and ADC values between two groups. pILC, an aggressive subtype of ILC, cannot be differentiated from cILC with breast MRI.
  • PublicationMetadata only
    A novel AVP gene mutation in a Turkish family with neurohypophyseal diabetes insipidus
    (2016-03-01) Ilhan, MAHMUT MUZAFFER; Tiryakioglu, N. O.; KARAMAN, O.; Coskunpinar, E.; YILDIZ, R. S.; TURGUT, SEDA; Tiryakioglu, D.; TOPRAK, HÜSEYİN; TASAN, ERTUĞRUL; İLHAN, MAHMUT MUZAFFER; KARAMAN, ÖZCAN; TURGUT, SEDA; TOPRAK, HÜSEYİN; TAŞAN, ERTUĞRUL
    Purpose Familial neurohypophyseal diabetes insipidus (FNDI) is a rare, autosomal dominant, inherited disorder which is characterized by severe polydipsia and polyuria generally presenting in early childhood. In the present study, we aimed to analyze the AVP gene in a Turkish family with FNDI.
  • PublicationMetadata only
    MR Enterography Features of Jejunal Lipoma Causing Intussusception: A Unique Case Report
    (2020-05-13T04:00:00Z) KILINÇ, YAĞMUR BAŞAK; SARI, LÜTFULLAH; KARABULUT, ÜMMÜHAN EBRU; AYKAN, MAHMUT ESAT; TOPRAK, HÜSEYİN; KILINÇ, YAĞMUR BAŞAK; SARI, LÜTFULLAH; KARABULUT, ÜMMÜHAN EBRU; AYKAN, MAHMUT ESAT; TOPRAK, HÜSEYİN
    Intussusception usually occurs in children due to benign causes, whereas in adults, it is mostly caused by malign causes in the colon. On the other hand, the causes of small bowel intussusceptions in adulthood are usually benign, such as polyps, lipomas, adenomas, and Meckel-s diverticulum. Intestinal lipomas are an uncommon entity among benign tumors. Here, we present MR enterography features of jejunojejunal intussusception caused by an intramural lipoma.
  • PublicationMetadata only
    Simultaneous mass-forming pseudoangiomatous stromal hyperplasia of the breast, axilla, and perineum.
    (2019-11-01T00:00:00Z) Kiran, T; Peker, A; Yilmaz, TF; Yildiz, S; TOPRAK, HÜSEYİN; YILMAZ, TEMEL FATİH; KIRAN, TUĞÇE; YILDIZ, ŞEYMA
  • PublicationOpen Access
    Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases
    (2021-12-22T00:00:00Z) Yilmaz, TEMEL FATİH; Gultekin, Mehmet Ali; Turk, Hacı Mehmet; Cesme, Dilek Hacer; Besiroglu, Mehmet; Simsek, Melih; Toprak, Huseyin; Alkan, ALPAY; YILMAZ, TEMEL FATİH; TÜRK, HACI MEHMET; ÇEŞME, DİLEK HACER; ŞİMŞEK, MELİH; ALKAN, ALPAY; TOPRAK, HÜSEYİN
    Background: We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values. Patients and methods: From January 2018 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive IHCC in our hospital's medical records. After exclusions, fifty-three patients with 53 liver metastases and 10 IHCC were included in our study. We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma. For mean apparent diffusion coefficient (ADCmean) values, the region of interests (ROI) was placed in solid portions of the lesions. ADCmean values of groups were compared. Results: The mean age of IHCC group was 62.50 ± 13.49 and mean age of metastases group was 61.15 ± 9.18. ADCmean values were significantly higher in the IHCC group compared to the metastatic group (p < 0.001). ROC curves method showed high diagnostic accuracy (AUC = 0.879) with cut-off value of < 1178 x 10-6 mm2/s for ADCmean (Sensitivity = 90.57, Specificity = 70.0, positive predictive value [PPV] = 94.1, negative predictive value [NPV] = 58.3) in differentiating adenocarcinoma metastases from IHCC. Conclusions: The present study results suggest that ADC values have a potential role for differentiation between IHCC and GIS adenocarcinoma liver metastases which may be valuable for patient management.