Person: TOPRAK, HÜSEYİN
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Publication Open Access MRI and MR Spectroscopy Features of Heat Stroke: A Case Report(2018-07-01) Yilmaz, TEMEL FATİH; Aralasmak, AYŞE; Toprak, HÜSEYİN; GULER, Serhat; Tüzün, Umit; Alkan, ALPAY; YILMAZ, TEMEL FATİH; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; ALKAN, ALPAYHeat stroke is the outcome of over heat stress that results in multiorgan dysfunction with a tendency for central nervous system damage. Brain is very sensitive to hyperthermia, especially the cerebellum that has selective vulnerability to heat stroke. There is complex interaction between heat cytotoxicity, coagulation disorder, cytotoxine - mediated systemic inflammatory response causing multiorgan failure, metabolic derangement, and circulatory insufficiency. We reviewed the literature and discussed brain MRI and MR spectroscopy findings of heat stroke, detailed the pathophysiology underlying brain involvement and proposed excitotoxic injury as an alternative mechanism of brain damage in heat stroke.Publication Open Access Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases(2021-12-22T00:00:00Z) Yilmaz, TEMEL FATİH; Gultekin, Mehmet Ali; Turk, Hacı Mehmet; Cesme, Dilek Hacer; Besiroglu, Mehmet; Simsek, Melih; Toprak, Huseyin; Alkan, ALPAY; YILMAZ, TEMEL FATİH; TÜRK, HACI MEHMET; ÇEŞME, DİLEK HACER; ŞİMŞEK, MELİH; ALKAN, ALPAY; TOPRAK, HÜSEYİNBackground: We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values. Patients and methods: From January 2018 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive IHCC in our hospital's medical records. After exclusions, fifty-three patients with 53 liver metastases and 10 IHCC were included in our study. We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma. For mean apparent diffusion coefficient (ADCmean) values, the region of interests (ROI) was placed in solid portions of the lesions. ADCmean values of groups were compared. Results: The mean age of IHCC group was 62.50 ± 13.49 and mean age of metastases group was 61.15 ± 9.18. ADCmean values were significantly higher in the IHCC group compared to the metastatic group (p < 0.001). ROC curves method showed high diagnostic accuracy (AUC = 0.879) with cut-off value of < 1178 x 10-6 mm2/s for ADCmean (Sensitivity = 90.57, Specificity = 70.0, positive predictive value [PPV] = 94.1, negative predictive value [NPV] = 58.3) in differentiating adenocarcinoma metastases from IHCC. Conclusions: The present study results suggest that ADC values have a potential role for differentiation between IHCC and GIS adenocarcinoma liver metastases which may be valuable for patient management.Publication Metadata only Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension(2019-05-01) Yilmaz, TEMEL FATİH; Aralasmak, AYŞE; Toprak, HÜSEYİN; MEHDI, Elnur; KOCAMAN, Gulsen; Kurtcan, SERPİL; Kaya, MEHMET ONUR; Alkan, ALPAY; YILMAZ, TEMEL FATİH; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; KURTCAN, SERPİL; KAYA, MEHMET ONUR; ALKAN, ALPAYPurpose To search for CSF dynamics of idiopathic intracranial hypertension (IIH) and communicating hydrocephalus and any correlation between MRI findings, CSF metrics and CSF opening pressure in IIH.Publication Metadata only Dynamic Contrast-Enhanced MR Perfusion in Differentiation of Benign and Malignant Brain Lesions.(2022-03-24T00:00:00Z) Cetinkaya, Ezra; Aralasmak, Ayse; Atasoy, Bahar; Tokdemir, Sevil; Toprak, Huseyin; Toprak, Ali; Kurtcan, Serpil; Alkan, ALPAY; TOPRAK, HÜSEYİN; ALKAN, ALPAYPublication Metadata only Auditory Pathway Features Determined by DTI in Subjects with Unilateral Acoustic Neuroma(2016-12-01) KURTCAN, SERPİL; Alkan, ALPAY; Kilicarslan, R.; BAKAN, A. A.; TOPRAK, HÜSEYİN; ARALASMAK, AYŞE; AKSOY, FEYZA MÜBERRA; Kocer, A.; KURTCAN, SERPİL; ALKAN, ALPAY; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞEIn the studies concerning the pathology of the auditory pathway in the vestibulocochlear system, few use advanced neuroimaging applications of magnetic resonance imaging (MRI) such as diffusion tensor imaging (DTI). Those who did use reported DTI changes only at the lateral lemniscus and inferior colliculus level. The aim of our study was to determine diffusion changes in the bilateral auditory pathways of subjects with unilateral acoustic neuroma (AN) and compare them with healthy controls.Publication Metadata only Comparison of TOF MRA, Contrast-Enhanced MRA and Subtracted CTA from CTP in Residue Evaluation of Treated Intracranial Aneurysms(2018-01-01) Dundar, TOLGA TURAN; Kits, Serkan; Ozdemir, HÜSEYİN; Seyithanoglu, MEHMET HAKAN; Uysal, Omer; Toprak, HÜSEYİN; Ozek, ERDİNÇ; Alkan, ALPAY; DÜNDAR, TOLGA TURAN; ARALAŞMAK, AYŞE; ÖZDEMİR, HÜSEYIN; SEYİTHANOĞLU, MEHMET HAKAN; UYSAL, ÖMER; TOPRAK, HÜSEYİN; KİTİŞ, SERKAN; ÖZEK, ERDİNÇ; ALKAN, ALPAYAIM: To compare effectiveness of contrast-enhanced magnetic resonance angiography (CE-MRA), 3D-Time-of-flight magnetic resonance angiography (3D-TOF-MRA) and subtracted computed tomography angiography from computed tomography perfusion (sub-CTA) in residue evaluation of intracranial aneurysms treated either with coiling or clipping.Publication Metadata only Evaluation of Auditory Pathways Using DTI in Patients Treated with Gamma Knife Radiosurgery for Acoustic Neuroma: A Preliminary Report(2018-09-01) Kurtcan, SERPİL; Hatiboglu, MUSTAFA AZİZ; Alkan, ALPAY; Toprak, HÜSEYİN; Seyithanoglu, MEHMET HAKAN; Aralasmak, AYŞE; Atasoy, BAHAR; Uysal, Omer; KURTCAN, SERPİL; HATİBOĞLU, MUSTAFA AZİZ; ALKAN, ALPAY; TOPRAK, HÜSEYİN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; ATASOY, BAHAR; UYSAL, ÖMERPurpose We aimed to evaluate the change in bilateral auditory pathways using diffusion tensor imaging (DTI) after gamma knife radiosurgery (GKR) and to determine the relationship between the radiosurgical treatment variables and DTI findings.Publication Metadata only MRI findings and utility of DWI in the evaluation of solid parathyroid lesions(2019-05-01) Yildiz, Seyma; Aralasmak, AYŞE; YETIS, Huseyin; KILICARSLAN, Rukiye; Sharifov, RASUL; Alkan, ALPAY; Toprak, HÜSEYİN; YILDIZ, ŞEYMA; ARALAŞMAK, AYŞE; SHARIFOV, RASUL; ALKAN, ALPAY; TOPRAK, HÜSEYİNPurpose To evaluate the MRI findings of solid parathyroid lesions and to elaborate on a possible improvement of MRI detection of parathyroid lesions by the use of additional DWI.Publication Metadata only MRI and MRS findings in fucosidosis; a rare lysosomal storage disease(2016-04-01) EDIZ, Suna Sahin; Aralasmak, AYŞE; YILMAZ, TEMEL FATİH; Toprak, HÜSEYİN; Yesil, GÖZDE; Alkan, ALPAY; ARALAŞMAK, AYŞE; YILMAZ, TEMEL FATİH; TOPRAK, HÜSEYİN; YEŞİL, GÖZDE; ALKAN, ALPAYFucosidosis is a rare lysosomal storage disorder caused by deficient activity of the enzyme L-fucosidase in all tissues. We presented magnetic resonance imaging [MRI] and MR spectroscopy [MRS] findings of a 4-year-old boy with genetically proven fucosidosis. He had a history and clinical findings of recurrent sinopulmonary infections, hypertonicity on lower extremities, gingival hypertrophy, bilateral ptosis, angiokeratoma corporis diffusum, and dysostosis multiplex. He had no organomegaly and urine glycosaminoglycan analysis were normal. MRI revealed abnormalities within the globus pallidus and periventricular and subcortical white matter. MRS showed a peak at the 3.8-3.9 ppm as a result of accumulating carbohydrate containing macromolecules and another peak at 1.2 which was doublet and inverted on TE 135, suggesting fructose peak. A final diagnosis of fucosidosis was proved by mutational analysis of FUCA1 gene which is responsible for the Fucosidosis phenotype. Two recent reports of MRS of two patients demonstrated that MRS is specific for fucosidosis. In this case, we aim to discuss fucosidosis with MRI and MRS findings accompanied by the literature. (c) 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rightsPublication Metadata only Neuroimaging Features of Acquired Metabolic and Toxic Encephalopathies(2018-01-01) EDIZ, Suna Sahin; Kurtcan, SERPİL; Alkan, ALPAY; Aydin, SİNEM; Tüzün, Umit; Toprak, HÜSEYİN; Aralasmak, AYŞE; KURTCAN, SERPİL; ALKAN, ALPAY; AYDIN, SİNEM; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞEBackground: Toxic and metabolic encephalopathies are easily misinterpreted or overlooked in daily neuroimaging practices.
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