Person: MİRAPOĞLU, SEMİH LÜTFİ
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- PublicationOpen AccessDoes ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?(2019-03-01) AYDOĞDU, İBRAHİM; İLBEY, YUSUF ÖZLEM; ÇOBAN, GANİME; EKİN, RAHMİ GÖKHAN; MİRAPOĞLU, SEMİH LÜTFİ; ÇAY, ALİ; KIZILTAN, HURİYE ŞENAY; EKİN, ZÜBEYDE YILDIRIM; SILAY, MESRUR SELÇUK; SEMERCİ, MEHMET BÜLENT; AYDOĞDU, İBRAHİM; ÇOBAN, GANİME; MİRAPOĞLU, SEMİH LÜTFİ; ÇAY, ALI; KIZILTAN, HURİYE ŞENAYObjective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)‑induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid‑reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation‑induced testicular damage. OT may be beneficial to the patients who underwent RT.
- PublicationOpen AccessTraumatic rupture of solid pseudopapillary tumors of the pancreas in children: A case report.(2016-11-01) MIRAPOĞLU, SEMİH LÜTFİ; AYDOGDU, I; Gucin, ZÜHAL; UMUTOGLU, T; KILINCASLAN, H; MİRAPOĞLU, SEMİH LÜTFİ; AYDOĞDU, İBRAHİM; GÜCİN, ZÜHAL; YILMAZ, TEMEL FATİHSolid pseudopapillary tumor (SPT) of the pancreas is a pathological entity rarely encountered in children. Despite its malignant characteristics, SPT has a favorable clinical prognosis. This tumor is more frequently observed in females and is commonly localized in the tail and body of the pancreas. This is the case report of a 9-year-old female patient who presented with severe abdominal pain of sudden onset and vomiting following blunt abdominal trauma. Upon physical examination, abdominal distension, tenderness and abdominal guarding were detected. Abdominal magnetic resonance imaging revealed a mass sized 8×9×12 cm in the pancreas, with hemorrhagic-necrotic areas, and abundant intra-abdominal fluid. Intra-abdominal exploration confirmed the presence of an abundant amount of intraperitoneal hemorrhagic fluid. A mass was identified, originating from the body and the tail of the pancreas, adherent to the mesentery of the colon and the hilum of the spleen, which had ruptured in its inferolateral side. The tumor was extirpated together with the spleen and the involved parts of the pancreas. Histopathological examination demonstrated a solid pseudopapillary tumor of pancreatic origin. The patient's postoperative course was uneventful, clinically as well as metabolically.
- PublicationOpen AccessMale Circumcision: Unending Debate(2017-04-01) Aydogdu, Ibrahim; Mirapoglu, SEMİH LÜTFİ; KILINCASLAN, Huseyin; AYDOĞDU, İBRAHİM; MİRAPOĞLU, SEMİH LÜTFİCircumcision, foreskin surrounds the penis called the glans pre-pusyum, mucous-covered means the removal by cutting a piece of skin. This process is probably the most discussed in the history of the world, is one of the oldest surgical procedures. Circumcision is primarily due to religious and cultural beliefs in certain parts of the world, while it is sometimes carried out in the absence of various medical indications. In this article, in our country, circumcision is being done very widely in the literature by examining the latest information on are summarized, and especially the debate about circumcision is intended to examine issues of.