Person: GÜNEŞ BAYIR, AYŞE
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Publication Open Access Food Allergy in Children(2021-07-01T00:00:00Z) GÜNEŞ BAYIR, AYŞE; Can, Busra; Ekingen, Seyma; GÜNEŞ BAYIR, AYŞEFood allergy, which is defined as an inverse immune response to food proteins, appears to increase gradually in children as a result of studies. It affects 6% of children and 3-4% of adults. The role of breast milk in preventing the development of allergies in children is controversial. Allergic reactions caused by food in children cause many symptoms and disorders affecting the gastrointestinal tract, respiratory tract and skin. These symptoms occur by immunoglobulin (Ig)E-mediated or non-IgE-mediated mechanisms. The cornerstone of food allergy treatment is removing foods from the diet by strict elimination method. Along with the genetic tendency, environmental factors can eliminate oral tolerance and cause food allergy. Disease results are affected by the immune system and trigger allergen properties. Foods that cause food allergies are a few, mainly milk, eggs, peanuts, nuts, fish and shellfish. In this review, the level of knowledge about the pathogenesis of the immunological response about most allergens, which are special substances in the protein structure found in foods, has been discussed with studies conducted. Thus, this study will shed light on identifying new immunotherapeutic approaches to allergens.Publication Open Access The Place and Importance of Propolis in Cancer Immunotherapy(2022-01-01T00:00:00Z) İpek, Nigahban; Pınarbaşı, Berna; Güneş Bayır, Ayşe; GÜNEŞ BAYIR, AYŞENowadays, the increasing number of cancer patients is a major concern all over the world. Therefore, finding safe and effective treatments has become one of the main goals of researchers. Immunotherapy is a form of treatment that allows the individual to fight against many diseases including cancer by using the immune system. The aim is to enable cells of the immune system to target and destroy cancer cells. Immunotherapeutic strategies in cancer are spread to a wide range of research areas including monoclonal antibodies, cancer vaccines, adoptive immunotherapy, cytokines, and immune system enhancing drugs. Due to the specificity of the immune response in new treatment methods, it is aimed that the immunity against the tumor is to destroy the tumor selectively without harming the patient. In recent scientific studies, it has been revealed that propolis is one of the most promising immunomodulating agents. Propolis is a natural medicine that widely used since ancient times and contains several bioactive compounds. More than 300 components of propolis have been identified to date and in vitro, in vivo and clinical studies of these components are ongoing. The major anticancer components in propolis are Convective available potential energy, chrysin, nemorosone, artepilin C, galangin and cardanol. The in vitro, in vivo and human clinical researches report that the propolis shows positive effect against the several different cancer types. Propolis as a natural food with these properties may support the immune system and body function of cancer patients.Publication Open Access Microbiological, chemical and sensory analyzes of produced probiotic yoghurts added clove and propolis(2020-09-01T00:00:00Z) Güneş Bayır, Ayşe; Bilgin, Mehmet Gültekin; Kutlu, Sümeyra Şeyma; Gölgeci, Fatma Nur; GÜNEŞ BAYIR, AYŞE; BİLGİN, MEHMET GÜLTEKİNPublication Open Access Evaluation of Some Physico-chemical and Antioxidant Characteristics of Commercial Honey Samples Originated from Different Regions of Turkey(2022-01-01T00:00:00Z) Bilgin, Mehmet Gültekin; Güneş Bayır, Ayşe; Özman, Zeynep; Babalı Balıbey, Fatmanur; Turgay, Feyzanur; Karakaş, İrem; Köse, Nesrin; Sevinç, Tülay; Selçuk, Tuğbanur; Öztürk, Nezire; BİLGİN, MEHMET GÜLTEKİN; GÜNEŞ BAYIR, AYŞE; ÖZMAN, ZEYNEP; BABALI BALIBEY, FATMANURPublication Open Access Determination and Evaluation of Olive Oils Offered for Sale in Istanbul Markets According to TS 894 and TS 341(2022-04-01T00:00:00Z) Yeşilkuşak, Ümmünur; Güneş Bayır, Ayşe; Özkan, Bilge; Kaya, Dilara; Arslan, Şeyma Sümeyye; BİLGİN, MEHMET GÜLTEKİN; GÜNEŞ BAYIR, AYŞEPublication Open Access Probiotics and Relationship Between Probiotics and Cancer Types(2021-10-01T00:00:00Z) Sener, Dilruba; Bulut, Hafsa Nur; GÜNEŞ BAYIR, AYŞE; GÜNEŞ BAYIR, AYŞECancer is a disease with a high mortality rate worldwide. Moreover, this rate is increasing day by day. It is expected to rise to first place by 2030, leaving cardiovascular diseases behind, which is the most common cause of death in the world. Today, it is known that cancer is the second most common cause of death. The process of cancer and its treatment reducethe quality of life. To improve this process, the effects of probiotics on some types of cancer, especially colorectal cancer, are examined in studies conducted today. Studies are showing that probiotics provide positive results in cancer prevention and treatment. However, some studies argue that they should not be used, putting forward the fact they may cause infection in patients with very weak immunity. The mechanisms for the antitumor properties of probiotics have not been fully explained yet. It is associated with some pathways which mainly focus on the gut microbiota. The opinion that the effects of probiotics on cancer are dependent on dose, strain, and species is accepted as a general conclusion. Besides, probiotics must be consumed regularly and the consumed product must contain the minimum number of microorganisms (approximately 100 g/day) to provide the intended effect. In this review, the effects of probiotics, of which positive and negative effects on individuals with cancer are still being discussed, on different types of cancer are presented in the light of current literature.Publication Open Access In Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells.(2020-07-17T00:00:00Z) Günes-Bayir, A; Kocyigit, A; Guler, Eray Metin; Dadak, A; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNThe concept of hormesis includes a biphasic cellular dose-response to a xenobiotic stimulus defined by low dose beneficial and high dose inhibitory or toxic effects. In the present study, an attempt has been made to help elucidate the beneficial and detrimental effects of thymol on different cell types by evaluating and comparing the impact of various thymol doses on cancerous (AGS) and healthy (WS-1) cells. Cytotoxic, genotoxic, and apoptotic effects, as well as levels of reactive oxygen species and glutathione were studied in both cell lines exposed to thymol (0-600 mu M) for 24 h. The results showed significant differences in cell viability of AGS compared to WS-1 cells exposed to thymol. The differences observed were statistically significant at all doses applied (P <= 0.001) and revealed hormetic thymol effects on WS-1 cells, whereas toxic effects on AGS cells were detectable at all thymol concentrations. Thymol at low concentrations provides antioxidative protection to WS-1 cells in vitro while already inducing toxic effects in AGS cells. In that sense, the findings of the present study suggest that thymol exerts a dose-dependent hormetic impact on different cell types, thereby providing crucial information for future in vivo studies investigating the therapeutic potential of thymol.