Person: GÜNEŞ BAYIR, AYŞE
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Publication Metadata only Cytotoxic and apoptotic activities of thymol from Thymus vulgaris on the human gastric adenocarcinoma cells(2015-06-10) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KARAKAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Cytotoxic, genotoxic and apoptotic activities of carvacrol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-08-01) GUNES-BAYIR, Ayse; Kiziltan, HURİYE ŞENAY; Guler, ERAY METİN; KARAKAS, Ersin; Kocyigit, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Thymus vulgaris komponenti timol’ün sitotoksik ve apoptotik aktivitelerinin gastrik adenokarsinoma hücrelerinde araştırılması(2015-10-30T00:00:00Z) GÜNEŞ BAYIR, AYŞE; Kızıltan, Huriye Şenay; GÜLER, ERAY METİN; KARATAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only In vitro effects of two major phenolic compounds from the family Lamiaceae plants on the human gastric carcinoma cells(2018-08-01) GÜNES-BAYIR, Ayse; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Cytotoxic, Genotoxic, Apoptotic And Reactive Oxygen Generating Effects Of Carvacrol On Human Fibroblast (Ws-1) And Gastric Adenocarcinoma (AGS) Cells(2016-10-30T00:00:00Z) GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Cytotoxic genotoxic and apoptotic activities of thymol from Thymus vulgaris on the human gastric adenocarcinoma cells(2015-10-23) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HÜRİYE ŞENAY; GÜLER, ERAY METİN; KARAKAŞ, ERSİN; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.(2018-11-01) Günes-Bayir, AYŞE; Kocyigit, ABDÜRRAHİM; Güler, ERAY METİN; Bilgin, MEHMET GÜLTEKİN; Ergün, İLYAS SAMET; DADAK, A; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; BİLGİN, MEHMET GÜLTEKİN; ERGÜN, İLYAS SAMETPublication Metadata only Cytotoxic, genotoxic and apoptotic activities of carvacrol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-09-02T00:00:00Z) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KARATAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Cytotoxic, genotoxic and apoptotic activities of thymol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-10-24T00:00:00Z) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KARATAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Effects of natural phenolic compound carvacrol on the human gastric adenocarcinoma (AGS) cells in vitro(2017-06-01) GUNES-BAYIR, Ayse; KIZILTAN, Huriye S.; Kocyigit, ABDÜRRAHİM; Guler, Eray M.; KARATAS, Ersin; Toprak, ALİ; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; TOPRAK, ALİGastric cancer (GC) is the most common cause of morbidity and mortality because of cancer. Medicinal plants containing polyphenolic compounds have gained importance in anticancer treatment. In this context, carvacrol is a main component of many plants in the family Lamiaceae that are frequently used in folk medicine and a good candidate to investigate for GC treatment. The present study aimed to explore the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS)-generating effects of carvacrol on gastric adenocarcinoma in vitro. For these purposes, human gastric adenocarcinoma (AGS) cells were used and analyzed after 24h of exposure to carvacrol with different concentrations. The cytotoxicity, ROS generation, glutathione (GSH) level, and genotoxicity were investigated by the ATP cell viability assay, 2,7-dichlorodihydrofluorescein-diacetate assay, GSH/GSSG-Glo assay, and comet assay, respectively. Apoptosis induction was detected by acridine orange/ethidium bromide staining and western blotting at below the half-maximal growth inhibitory concentration value. Carvacrol showed cytotoxic, genotoxic, apoptotic, ROS generating, and GSH-reducing effects on AGS cells in a dose-dependent manner. There was a close negative relationship between cell viability and ROS level. Carvacrol inhibited the proliferation of AGS cells, suggesting that it could be a novel and strong anticancer agent against the human gastric adenocarcinoma. These results support the interest of natural diet components in the development of therapeutic products for diseases.