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ŞAHBAZ, ÇIĞDEM DILEK

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ÇIĞDEM DILEK
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ŞAHBAZ
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Now showing 1 - 10 of 15
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    Is there an association between theory of mind ability and biological rhythm disturbances in individuals with schizophrenia?
    (2018-03-01T00:00:00Z) Sahbaz, C.; Kurtulmus, A.; Kirpinar, I.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMET
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    A role of T cell subsets in the immun dysfunction of schizophrenia
    (2018-03-01T00:00:00Z) Sahbaz, C.; Zibandeh, N.; Kurtulmus, A.; Kirpinar, I.; Sahin, F.; Akkoc, T.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMET
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    Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia
    (2020-06-01T00:00:00Z) Sahbaz, Cigdem; Zibandey, Noushin; KURTULMUŞ, AYŞE; Duran, Yazgul; Gokalp, Muazzez; KIRPINAR, İSMET; ŞAHİN, FİKRETTİN; Guloksuz, Sinan; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
    Aim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.
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    PublicationOpen Access
    Chronotype anc Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome
    (2021-01-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; Sahbaz, Cigdem Dilek; Dogu, Zeynep Filiz Eren; TAKMAZ, TAHA; ÇALI, HALİME; Tanoglu, Basak; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHBAZ, ÇIĞDEM DILEK; TAKMAZ, TAHA; ÇALI, HALİME
    Aim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients.
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    Biological rhythm disturbances in major depressive disorder
    (2019-04-01) Ozcelik, A. M.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEK
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    Effect of chronotype on academical performance of medical students
    (2019-04-01) Darbaz, B.; Topal, A.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEK
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    PublicationOpen Access
    Chronotype and Sleep Quality in Patients with Inflammatory Bowel Disease
    (2020-01-01T00:00:00Z) Keskin, Elmas; Sahbaz, Cigdem Dilek; BİBERCİ KESKİN, ELMAS; ŞAHBAZ, ÇIĞDEM DILEK
    Aim: Chronotype and sleep disturbance are both considered risk factors for chronic autoimmune diseases. However, there is lack of knowledge with respect to chronic inflammatory bowel disease and chronotype patterns. Therefore, we investigated the chronotype and sleep quality in patients with ulcerative colitis and Crohn-s disease.
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    Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer-s disease
    (2019-10-01) Elibol, Birsen; Şahbaz, Çiğdem Dilek; Beker, Merve; Terzioğlu, Şule; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVE; ŞAHBAZ, ÇIĞDEM DILEK
    OBJECTIVES: Alzheimer-s disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in A beta((1-42)) infused rat model of AD.
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    Circadian preferences are associated with vegetative symptoms and comorbid medical diseases in patients with major depression
    (2019-09-03) Sahbaz, Çiğdem Dilek; Devetzioglou, Tougmpa; Ozcelik, Ayse Mine; KIRPINAR, İSMET; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMET
    Circadian preferences may affect the severity and symptom structure of depression and could influence specific symptom clusters of depression. This study aims to examine the relationship between chronotypes and symptomatology in patients with major depression. One hundred and one drug-naive outpatients with major depression were evaluated through the use of the Hamilton Rating Scale for Depression (HRSD). The Morningness-Eveningness Questionnaire (MEQ) was used to the define chronotypes and the quality of subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI). The medical records of patients were evaluated retrospectively to determine the presence of another medical illness. HRSD total score and cognitive and vegetative factor scores were significantly higher in the evening chronotype than in the morning and intermediate chronotypes (p < .001). In the regression analysis, MEQ total score was inversely related to HRSD-vegetative factor score (p < .001). The ratio of comorbid illness was found to be statistically significant among depressed patients with evening chronotype (p = .001). Additionally, binary logistic regression analysis was performed to ascertain the likelihood of participants having comorbid medical illness; only age (p = .010) and MEQ total score (p = .011) were associated with exhibiting comorbid illness. General and psychiatric clinical examinations need to be considered with the understanding of circadian preference.
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    PublicationOpen Access
    Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus.
    (2019-01-01) Sahbaz, CD; Elibol, BİRSEN; Beker, M; Kilic, U; Jakubowska-Doğru, E; ELİBOL, BİRSEN; ŞAHBAZ, ÇIĞDEM DILEK
    It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal alcohol - and maternal stress‑induced morphological and functional deficits correlates with compensatory changes in the expression/activation of the brain proteins involved in inflammation, cell survival and apoptosis. In this project, we investigated the hippocampus which belongs to the brain regions most susceptible to the adverse effects of prenatal ethanol exposure. Pregnant rat dams were administered ethanol (A) or isocaloric glucose solution (IC) by a gastric intubation during gestational days 7-20. The pure control group received ad libitum laboratory chow and water with no other treatment. The hippocampi of fetal-ethanol and control pups were examined at the postnatal day (PD)1, PD10, PD30 and PD60. Moderate fetal-ethanol exposure and prenatal intubation stress caused a significant increase in molecular factors relating to inflammation (iNOS) and cell survival/apoptosis pathways (PTEN, GSK-3 and ERK) at birth, with a rapid compensation from these developmental deficits upon removal of alcohol at PD10. Indeed, an increase in ERK1/2 and JNK1/2 activation at PD30 was observed with ethanol consumption. It indicates that the recovery process in A and IC brains started soon after the birth upon the ethanol and stressor withdrawal and continued until the adulthood.