Person: ŞAHBAZ, ÇIĞDEM DILEK
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Publication Metadata only Is there an association between theory of mind ability and biological rhythm disturbances in individuals with schizophrenia?(2018-03-01T00:00:00Z) Sahbaz, C.; Kurtulmus, A.; Kirpinar, I.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMETPublication Metadata only Necroptosis Might be a Time Dependent Neuronal Cell Death Mechanism on Hippocampus After Chronic Restraint Stress(2019-05-15) Sahbaz, Cigdem; ELİBOL, BİRSEN; ŞAHBAZ, ÇIĞDEM DILEK; ELİBOL, BİRSENPublication Metadata only A role of T cell subsets in the immun dysfunction of schizophrenia(2018-03-01T00:00:00Z) Sahbaz, C.; Zibandeh, N.; Kurtulmus, A.; Kirpinar, I.; Sahin, F.; Akkoc, T.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMETPublication Metadata only Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia(2020-06-01T00:00:00Z) Sahbaz, Cigdem; Zibandey, Noushin; KURTULMUŞ, AYŞE; Duran, Yazgul; Gokalp, Muazzez; KIRPINAR, İSMET; ŞAHİN, FİKRETTİN; Guloksuz, Sinan; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETAim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.Publication Open Access Chronotype anc Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome(2021-01-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; Sahbaz, Cigdem Dilek; Dogu, Zeynep Filiz Eren; TAKMAZ, TAHA; ÇALI, HALİME; Tanoglu, Basak; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHBAZ, ÇIĞDEM DILEK; TAKMAZ, TAHA; ÇALI, HALİMEAim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients.Publication Metadata only Biological rhythm disturbances in major depressive disorder(2019-04-01) Ozcelik, A. M.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEKPublication Metadata only Effect of chronotype on academical performance of medical students(2019-04-01) Darbaz, B.; Topal, A.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEKPublication Metadata only Attachment styles and theory of mind abilities non-psychotic adult offspring of patients with schizophrenia(2019-04-09) ŞAHBAZ, ÇİĞDEM DİLEK; ŞAHBAZ, ÇIĞDEM DILEKPublication Metadata only Role of Lymphocyte Subsets and T-Cell Profiles in the Immune Dysfunction of Schizophrenia(2018-05-01) SAHBAZ, Cigdem; Zibandeyeh, Noushin; Kurtulmus, AYŞE; AVAROGLU, Gamze; Kirpinar, Ismet; Sahin, Fikrettin; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETPublication Metadata only Evening Chronotype Is Associated with Medical Comorbities and Factor Structure of Depression: A Descriptive Study(2018-06-24) ŞAHBAZ, ÇİĞDEM DİLEK; ŞAHBAZ, ÇIĞDEM DILEK