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KUMAŞ, MELTEM

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Kurumdan Ayrılmıştır
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MELTEM
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KUMAŞ
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Now showing 1 - 10 of 22
  • PublicationMetadata only
    A skeletochronological study of age, growth and longevity in two freshwater turtles, Emys orbicularis and Mauremys rivulata from Mediterranean Turkey (Reptilia: Testudines).
    (2016-02-01) Ayaz, Dinçer; Çiçek, Kerim; KUMAŞ, MELTEM; Tok, Cemal Varol; KUMAŞ, MELTEM
    We estimated growth parameters of Emys orbicularis and Mauremys rivulata in Mediterranean Turkey with the skeletochronological method, using specimens drowned in fyke nets. In adult E. orbicularis, the median age was 8 years in males and 10 years in females. The median age of adult M. rivulata was 10 years for both sexes. Both species reach sexual maturity at an age of 5-7 years. No difference was found in age composition between the sexes.
  • PublicationMetadata only
    Skin Pigmentation of Stellagama stellio (L. 1758) (Reptilia: Agamidae) Depends on Climate Conditions and Altitude
    (2017-09-01) Çiçek, Kerim; KUMAŞ, MELTEM; Ayaz, Dinçer; KUMAŞ, MELTEM
    We studied skin pigmentation characteristics of the starred agama, Stellagama stellio, at different altitudes and climate conditions from Anatolia, Turkey. The epidermis was composed of stratum corneum and stratum basale, while the dermis occupied a much larger area. Melanophores were only found in the dermis and melanin pigments exhibited different distribution patterns in cells. Our results indicated that the skin pigmentation of S. stellio varied among populations depending on the altitude and climatic conditions. At higher altitudes, the melanophores in dorsal skin were larger and its melanin pigments aggregated in melanophores. The aggregation of the melanin pigments indicated the skin had lighter colour. The melanin pigments tended to be dispersed at lower altitudes. The skin of populations inhabiting hot climates and lower altitudes was more pigmented, while populations from steppe and higher altitudes exhibit lower pigmentation when comparing melanophores areas.
  • PublicationMetadata only
    An observation of haversian systems in Stellagama stellio (Linnaeus, 1758) (Squamata: Sauria: Agamidae) in Barla/Isparta, Turkey
    (2015-01-01T00:00:00Z) Kumas, MELTEM; AYAZ, DİNÇER; KUMAŞ, MELTEM
    In this study, we observed haversian systems on the endosteal surface of the femur bone of one male individual of Roughtail Rock Agama, Stellagama stellio, which was collected from Barla/Isparta province of Turkey. It was observed that the haversian canal was located on the center of the haversian systems or secondary osteons, and it was surrounded by concentric lamellae. All lamellae were separated from each other by a cement line that stained darker than other constituents. Volkmann-s canals were not observed between haversian canals, and other concentric lamellae were not encountered between periosteum and haversian systems. These results indicate that remodeling can be partly seen in this species. Our study is important in terms of being the first record to demonstrate haversian systems on the femur bone of S. stellio.
  • PublicationOpen Access
    Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats
    (2016-12-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Bayindir, NİHAN; Iraz, Meryem; Ayhan, Siddika; Meydan, SEDAT; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN; MEYDAN, SEDAT
    Objective: We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats. Methods: Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Results: Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05). Conclusion: Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.
  • PublicationMetadata only
    Age determination and long bone histology in Stellagama stellio (Linnaeus, 1758) (Squamata: Sauria: Agamidae) populations in Turkey
    (2014-05-01T00:00:00Z) KUMAŞ, Meltem; AYAZ, DİNÇER; KUMAŞ, MELTEM
    In this study, the age structures of the four populations of Roughtail Rock Agama, Stellagama stellio distributed in Turkey were determined and their long bone development was examined from a histological perspective. The ages of some 218individuals (32 juveniles, 86 male male, 100 female female) captured from the Mediterranean, Transitional Mediterranean, Aegean, and Central Anatolia Regions were computed with the method of skeletochronology, and the correlation between age and the SVL (the snout-vent length) was compared. The mean SVL was greater in males than in females, and this difference was found statistically significant in all populations except for the Central Anatolian population. The mean ages for male and female individuals were calculated as 3.44 +/- 1.26 and 3.18 +/- 1.18 years in the Mediterranean population, as 4.65 +/- 1.25 and 3.69 +/- 1.31 years in the Transitional Mediterranean population, as 4.05 +/- 1.32 and 3.36 +/- 1.46 years in the Aegean population, and as 4.20 +/- 1.87 and 3.60 +/- 2.01 years in the Central Anatolian population, respectively. The oldest individuals were encountered in the Central Anatolian populations, and the maximum age detected for both sexes was 7 years. It was determined that the age at maturity was 3 in all the populations under examination and that there was not any difference in age at maturity either among the populations or between sexes. There was a significant positive correlation between age and the SVL. The impacts of environmental factors on age structures were examined, and altitude, latitude and climate were found effective on longevity. Histologically, the primary bone, which developed in the embryonic period, was preserved throughout the life of a species even in the oldest individual. Neither secondary bone development nor formation of lamellar systems was encountered. It was seen that intramembranous and endochondral ossification mechanisms played a joint role in long bone development.
  • PublicationOpen Access
    Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats
    (2019-01-01) Kanbay, Songül; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; Karataş, Ersin; Duymaç, Nurcihan; ERGÜN, İLYAS SAMET; ÜYÜKLÜ, MEHMET; KOÇYİĞİT, ABDÜRRAHİM; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; ERGÜN, İLYAS SAMET; ÜYÜKLÜ, MEHMET; KOÇYİĞİT, ABDÜRRAHİM
    Background: Ischemia-reperfusion injury causes various severe morphological and functional changes in diabetic patients. To date, numerous antidiabetic and antioxidant agents have been used for treatment of the disease-related changes. Objectives: We aimed to examine effective therapeutic doses or doses of berberine against renal ischemia/reperfusion injury (IRI) in a streptozotocin (STZ)-induced diabetic rat model by histopathological and biochemical analysis. Methods: Thirty male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: STZ-induced diabetic group (STZ); IRI-induced diabetic group (STZ+IRI); 50mg/kg berberine (BRB) treated diabetic group after inducing IRI (STZ+IRI+BRB1); 100mg/kg BRB treated diabetic group after IRI (STZ+IRI+BRB2); 150mg/kg BRB treated diabetic group after IRI (STZ+IRI+BRB3). Bilateral renal ischemia model was applied for 45min, then reperfusion was allowed for 14 days in STZ-induced diabetic rats. Renal injury was detected histopathologically. Blood urea nitrogen (BUN), creatinine and lactate dehydrogenase (LDH) levels were measured in serum using the ELISA method. Total antioxidant status (TAS) and total oxidant status (TOS) of renal tissue was studied by spectrophotometric assay. Oxidative stress index (OSI) was calculated as TOS-to-TAS ratio. Tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), Na+/K+-ATPase (sodium pump), and Ca2+-ATPase (calcium ATPase) enzyme levels were measured in tissues using the ELISA method. Anti-apoptotic Bax and pro-apoptotic Bcl-2 protein levels were detected by Western blot analysis. All data were evaluated statistically. Results: The highest histopathological score was detected in the STZ+IRI group compared to the other group. BRB administration at the doses of 100mg/kg and 150mg/kg markedly improved renal injury. BUN and creatinine levels significantly increased in the STZ+IRI group compared to the STZ group (p<0.001). 100mg/kg and 150mg/kg BRB administration significantly decreased those levels (p<0.01). The highest TOS and the lowest TAS levels were detected in the STZ+IRI group (p<0.001). IRI markedly aggravated inflammation via increasing levels of TNF-α and CRP (<0.001), and caused apoptosis via inducing Bcl-2 protein, and suppressing Bax protein (p<0.001). BRB administration at the doses of 100mg/kg and 150mg/kg showed anti-oxidant, anti-inflammatory and anti-apoptotic effects (p<0.01). The LDH enzyme, was used as a necrosis marker, was higher in the STZ+IRI group than other groups. BRB administration at all of the doses, resulted in the decline of LDH enzyme level (p<0.001). Ca2+-ATPase and Na+/K+-ATPase enzyme activities decreased in the STZ+IRI group compared to the STZ group (p<0.001), while BRB administration at the doses of 100mg/kg and 150mg/kg significantly increased those of enzyme activities, respectively (p<0.05). Conclusion: Ischemia with diabetes caused severe histopathological and biochemical damage in renal tissue. The high doses of berberine markedly improved histopathological findings, regulated kidney function via decreasing BUN and creatinine levels, and rearranged intercellular ion concentration via increasing Na+/K+-ATPase and Ca2+- ATPase levels. Berberine showed anti-oxidant, anti-apoptotic, and anti-inflammatory effects. According to these data, we suggest that berberine at the doses of 100 and 150mg may be used as a potential therapeutic agent to prevent renal ischemic injury.
  • PublicationOpen Access
    Protective effect of ischemic preconditioning on myocardium against remote tissue injury following transient focal cerebral ischemia in diabetic rats Efeito protetor do pré-condicionamento isquêmico no Miocárdio contra lesão remota de tecidos após isquemia cerebral focal transitória em ratos diabéticos
    (2017-12-01) KUMAŞ, MELTEM; ALTINTAS, Ozge; Karatas, Ersin; KOÇYİĞİT, ABDÜRRAHİM; KUMAŞ, MELTEM; KOÇYİĞİT, ABDÜRRAHİM
    Background: Remote ischemic preconditioning (IPreC) could provide tissue-protective effect at a remote site by anti-inflammatory, neuronal, and humoral signaling pathways. Objectives: The aim of the study was to investigate the possible protective effects of remote IPreC on myocardium after transient middle cerebral artery occlusion (MCAo) in streptozotocin- induced diabetic (STZ) and non-diabetic rats. Methods: 48 male Spraque Dawley rats were divided into eight groups: Sham, STZ, IPreC, MCAo, IPreC+MCAo, STZ+IPreC, STZ+MCAo and STZ+IPreC+MCAo groups. We induced transient MCAo seven days after STZ-induced diabetes, and performed IPreC 72 hours before transient MCAo. Remote myocardial injury was investigated histopathologically. Bax, Bcl2 and caspase-3 protein levels were measured by Western blot analysis. Total antioxidant status (TAS), total oxidant status (TOS) of myocardial tissue were measured by colorimetric assay. Oxidative stress index(OSI) was calculated as TOS-to-TAS ratio. For all statistical analysis, p values < 0.05 were considered significant. Results: We observed serious damage including necrosis, congestion and mononuclear cell infiltration in myocardial tissue of the diabetic and ischemic groups. In these groups TOS and OSI levels were significantly higher; TAS levels were lower than those of IPreC related groups (p < 0.05). IPreC had markedly improved histopathological alterations and increased TAS levels in IPreC+MCAo and STZ+IPreC+MCAo compared to MCAo and STZ+MCAo groups (p < 0.05). In non-diabetic rats, MCAo activated apoptotic cell death via increasing Bax/Bcl2 ratio and caspase-3 levels. IPreC reduced apoptotic cell death by suppressing pro-apoptotic proteins. Diabetes markedly increased apoptotic protein levels and the effect did not reversed by IPreC. Conclusions: We could suggest that IPreC attenuates myocardial injury via ameliorating histological findings, activating antioxidant mechanisms, and inducing antiapoptotic activity in diabetic rats.
  • PublicationMetadata only
    Investigation of the histological development of the frontal ganglion in Locusta migratoria L. 1758 (Orthoptera, Acrididae)
    (2012-01-01T00:00:00Z) Kumas, MELTEM; Karakisi, Hatice; KUMAŞ, MELTEM
    The frontal ganglion plays a critical role in insect feeding and molting-related behaviors. It is present in all insect orders at all developmental stages. In this study, the histological development of the frontal ganglion of Locusta migratoria, the African migratory locust, was investigated. Ganglia were dissected at 3 distinct developmental stages and their histological structure was evaluated at the light microscope level. The development of the cells generating the ganglion in the first and fifth nymphal stages and in adults was determined using the variance analysis method. Total width and length of the ganglion cells as well as width and length of the nucleus were measured. A significant expansion of the cell and nucleus diameter was observed during development from the youngest stage toward adulthood.
  • PublicationMetadata only
    Age, Growth and Longevity of Kotschy-s Gecko, Mediodactylus kotschyi (Steindachner, 1870) (Reptilia, Gekkonidae) from Central Anatolia, Turkey
    (2015-09-01T00:00:00Z) Çiçek, Kerim; Ayaz, Dinçer; Afsar, Murat; KUMAŞ, MELTEM; Tok, Cemal Varol; KUMAŞ, MELTEM
    We studied the age structure of Kotschy-s gecko, Mediodactylus kotschyi, from the Sultan Mountains (Central Anatolia, Turkey) using the skeletochronological method. We examined the humeral diaphyseal cross sections of a total of 19 (six males and 13 females) museum specimens. Our results showed that the age structure ranged from three to seven years (mean = 4.2 years, SD = 1.47) in males and from two to eight years (mean = 4.5 years, SD = 1.81) in females. Both sexes reached sexual maturity after their second hibernation, and no statistically significant difference in age composition was observed between the sexes. There was a strong positive correlation between SVL and age (Spearman-s correlation coefficient, r = 0.93) and Von Bertalanffy growth curves fitted to the relationships between age (k = 0.80) and SVL (SVLmax = 42.4). In conclusion, M. kotschyi is a short-lived species with a high growth rate.
  • PublicationMetadata only
    Relationship between regular exercise-induced cardiac hypertrophy and micro RNA
    (2017-09-01) Pala, M.; Altan, M.; Sonmez, O. F.; Mengi, M.; Dincer, S.; AKBAS, FAHRİ; Yildiz, M.; KUMAS, MELTEM; Esrefoglu, MUKADDES; Metin, G.; AKBAŞ, FAHRİ; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES