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EKİNCİ, CANSU

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CANSU
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EKİNCİ
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Now showing 1 - 6 of 6
  • PublicationOpen Access
    Evaluation of amblyopic eyes with optical coherence tomography angiography and electrophysiological tests
    (2021-01-01T00:00:00Z) Hamurcu, Mualla; EKİNCİ, CANSU; Koca, Semra; TUĞCU, Betül; EKİNCİ, CANSU; TUĞCU, BETÜL
    Purpose: To investigate the structural and functional changes of the retina and optic nerve in amblyopia. Methods: Eighteen patients with unilateral anisometropic amblyopia and 27 age-matched healthy controls were involved in this study. All patients underwent optical coherence tomography angiography (OCTA), pattern visual evoked potential (pVEP), and flash electroretinogram (fERG). Results: There was no statistically significant difference in terms of the fovea] avascular zone (FAZ), perifoveal superficial density, whole superficial density, parafoveal deep density, perifoveal deep density among the eyes (P > 0 0.05). Significant differences were found only in superficial capillary plexus (SCP) vessel density in whole (P = 0.029) and parafoveal (P = 0.008) image. In electrophysiological tests, while VEP latencies of the amblyopic eyes increased compared to nonamblyopic eyes and controls (P = 0.027), VEP amplitudes decreased in amblyopic and nonamblyopic eyes compared to controls (P = 0.01), amplitudes of the rod (P = 0.027) and cones (P < 0.001) also decreased in amblyopic eyes compared to nonamblyopic and healthy eyes. When we assessed the correlation between the parameters of OCTA and electrophysiological test, only a significant correlation was found between parafoveal SCP vessel density and VEP amplitudes (r = 0.341). Conclusion: We found a significant decrease only in SCP vessel density of the OCTA parameters in amblyopic eyes compared to healthy eyes. We detected a significant relationship between parafoveal SCP vessel density and VEP parameters, which might be associated with the underlying pathophysiology of the amblyopia.
  • PublicationMetadata only
    Güncel Vitreoretinal Cerrahi
    (2021-10-01T00:00:00Z) Özdemir, Mehmet Hakan; Ekinci, Cansu; ÖZDEMİR, MEHMET HAKAN; EKİNCİ, CANSU
  • PublicationMetadata only
    Effects of 1,25 Dihydroxyvitamin D3 on Human Retinal Pigment Epithelial Cell Lines.
    (2021-05-22T00:00:00Z) Ekinci, Cansu; Guler, Eray Metin; Kocyigit, ABDÜRRAHİM; Ozdemir, Hakan; EKİNCİ, CANSU; KOÇYİĞİT, ABDÜRRAHİM; KIRIK, FURKAN
  • PublicationMetadata only
    Regional analysis of segmented-macular structure in patients with myopic anisometropia
    (2021-06-01T00:00:00Z) KIRIK, FURKAN; EKİNCİ, CANSU; AKBULUT, ERSİN; BAYRAKTAR, HAVVANUR; Ozdemir, Hakan; KIRIK, FURKAN; EKİNCİ, CANSU; AKBULUT, ERSİN; BAYRAKTAR, HAVVANUR; ÖZDEMİR, MEHMET HAKAN
    Purpose To compare intraretinal layers between the eyes in patients with myopic anisometropia, and evaluate the relationship between the layers with spherical equivalent (SE) and axial length (AL). Methods In this retrospective study, the more myopic (MM) and fellow (F) eyes of 41 patients with myopic anisometropia, and 38 emmetropic (+/- 0.50 diopter) control (C) eyes were inclueded. Intraretinal layer segmentation was performed by optical coherence tomography. Global volumes of retinal layers and their thicknesses in nine macular regions were compared. Correlation analysis was used to determine the relationship with SE and AL in each layer. Results Total retinal, ganglion cell (GCL), inner nuclear (INL), and outer plexiform (OPL) layer volumes in MM eyes were less than in C eyes, while INL and OPL were less than in F eyes. There was no difference in the fovea, except for the retinal pigment epithelium. In MM eyes, only INL and OPL were thin in at least one perifoveal and parafoveal quadrant compared to F eyes. Only INL and OPL thicknesses were significantly correlated with both SE and AL in all perifoveal quadrants. In contrast to the thinning found in MM eyes, the only layer in which thickening was detected to compare to C eye was nerve fiber layer (NFL), which correlated positively with SE and negatively with AL. Conclusion While the fovea is less affected by myopia, thinning becomes remarkable in the perifoveal quadrants. Despite thinning in many layers, especially INL and OPL, NFL thickening may be seen due to myopia.
  • PublicationMetadata only
    The effect of platelet-rich fibrin on wound healing following strabismus surgery
    (2022-06-01T00:00:00Z) TUĞCU, Betül; BAYRAKTAR, HAVVANUR; EKİNCİ, CANSU; Kucukodaci, Zafer; TUNALI, Mustafa; NUHOĞLU, FADİME; TUĞCU, BETÜL; BAYRAKTAR, HAVVANUR; EKİNCİ, CANSU; TUNALI, MUSTAFA; NUHOĞLU, FADİME
    Purpose To investigate the effect of platelet-rich fibrin (PRF) on post-operative wound healing following strabismus surgery in a rabbit model. Methods Nine New Zealand white rabbits were involved in the study. One of these nine rabbits was kept in control without having any operation. Both eyes of eight rabbits underwent superior rectus muscle (SRM) resection. After resection of SRM, PRF was applied to SRM of the right eyes. In the left eye, SRM was not wrapped with PRF and served as a control. The rabbits were sacrificed and enucleated 6 weeks after the surgery. Inflammation and vascular proliferation were assessed by staining with haematoxylin-eosin. Scar and fibrosis were examined by the Masson trichrome staining. Immunohistochemical staining was performed for a vascular endothelial growth factor (VEGF) and alpha-smooth muscle actin (alpha-SMA). Results There was no significant difference in terms of inflammation (p = 0.535), vascularization (p = 0.602), and fibrosis (p = 0.745) between the eyes. Immunohistochemical staining for VEGF demonstrated no significant difference (p = 0.745). However, significant staining for alpha-SMA was detected in PRF-treated eyes compared with control eyes (p = 0.037). Conclusion Consistent with the hypothesis that PRF facilitates wound healing as a biocatalyst, there was only a significant difference for alpha-SMA related to myofibroblast activity which is important for wound remodelling. Future comprehensive studies are needed to extend these results.
  • PublicationOpen Access
    Coronavirus (COVID-19) and its Relationship with Ocular Surface
    (2021-02-01T00:00:00Z) EKİNCİ, CANSU; ÖZDEMİR, MEHMET HAKAN; EKİNCİ, CANSU; ÖZDEMİR, MEHMET HAKAN
    An outbreak in China-s Wuhan city in December 2019, characterized by unidentified pneumonia, leading to severe acute respiratory distress syndrome has begun. The cause of the outbreak has been detected as Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2), which is a new coronavirus and due to its rapid spread in a short time, it has been announced as a pandemic in terms of public health by the World Health Organization. The virus is transmitted mainly by direct contact with the secretions of patients and inhalation of virus-containing micro-droplets. The transmission of the virus via the ocular route is a controversial issue and there arc limited number of studies in the literature. Follicular conjunctivitis may he one of the ocular manifestations of the disease and even if there is no concomitant conjunctivitis, it is very important for the ophthalmologists and healthcare professionals to take preventive measures. In this review, the relationship of SARS-CoV-2 with ocular surface findings was evaluated in the light of the literature.