Person: SÜMBÜL, BİLGE
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Publication Metadata only Çocukluk Çağı Alerjik Rinitinde Nazal Sıvı Beta Defensi2 Düzeylerinin İncelenmesi(2016-04-27) DILEK, FATIH; ÖZKAYA, EMİN; GÜLTEPE, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKAN; GEDIK, AHMET HAKAN; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKANPublication Open Access Discordance between Serum Neutralizing Antibody Titers and the Recovery from COVID-19(2020-09-25T00:00:00Z) Koç, Mm; Kalkan, Yazıcı; Çetin, Nesibe Selma; Doymaz, Mz; Sümbül, B; Durdu, B; YAZICI, MERVE; MERİÇ KOÇ, MELİHA; ÇETİN, NESİBE SELMA; KARAASLAN, ELİF; OKAY, GÜLAY; DURDU, BÜLENT; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYAThe recent pandemic of COVID-19 has caused a tremendous alarm around the world. Details of the infection process in the host have significant bearings on both recovery from the disease and on the correlates of the protection from the future exposures. One of these factors is the presence and titers of neutralizing Abs (NAbs) in infected people. In the current study, we set out to investigate NAbs in the recovered subjects discharged from the hospital in full health. Serum samples from a total of 49 documented consecutive COVID-19 subjects were included in the study. All the subjects were adults, and serum samples collected during the discharge were tested in viral neutralization, enzyme immunoassay (EIA), and Western immunoblot tests against viral Ags. Even though a majority of the recovered subjects had raised significant NAb titers, there is a substantial number of recovered patients (10 out of 49) with no or low titers of NAbs against the virus. In these cohorts as well as in patients with high NAb titers, viral Ag binding Abs were detectable in EIA tests. Both NAb titers and EIA detectable Abs are increased in patients experiencing a severe form of the disease, and in older patients the Ab titers were heightened. The main conclusion is that the recovery from SARS-CoV-2 infection is not solely dependent on high NAb titers in affected subjects, and this recovery process is probably produced by a complex interplay between many factors, including immune response, age of the subjects, and viral pathology.Publication Open Access Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study(2021-02-01T00:00:00Z) SÜMBÜL, BİLGE; Sumbul, Hilmi Erdem; OKYAY, RAMAZAN AZİM; Gulumsek, Erdinc; ŞAHİN, AHMET RIZA; Boral, Baris; Kocyigit, Burhan Fatih; Alfishawy, Mostafa; Gold, Jeffrey; Tasdogan, Ali Muhittin; SÜMBÜL, BİLGEBackground: There is growing evidence indicating that children are less affected from COVID-19. Some authors speculate that childhood vaccinations may provide some cross-protection against COVID-19. In this study, our aim was to compare the circulating antibody titers for multiple childhood vaccine antigens, as an indicator of the state of immune memory between patients with COVID-19 and healthy controls, with a specific aim to identify the association between disease severity and antibody titrations which may indicate a protective function related to vaccine or disease induced memory. Methods: This study is a case-control study including 53 patients with COVID-19 and 40 healthy volunteers. COVID-19 severity was divided into three groups: asymptomatic, mild and severe. We measured the same set of antibody titers for vaccine antigens, and a set of biochemical and infection markers, in both the case and control groups. Results: Rubella (p = 0.003), pneumococcus (p = 0.002), and Bordetella pertussis (p < 0.0001) titers were found to be significantly lower in the case group than the control group. There was a significant decline in pneumococcus titers with severity of disease (p = 0.021) and a significant association with disease severity for Bordetella pertussis titers (p = 0.014) among COVID patients. Levels of AST, procalcitonin, ferritin and D-dimer significantly increased with the disease severity. Discussion: Our study supports the hypothesis that pre-existing immune memory, as monitored using circulating antibodies, acquired from childhood vaccinations, or past infections confer some protection against COVID-19. Randomized controlled studies are needed to support a definitive conclusionPublication Open Access Screening of mecC Gene in Methicillin Resistant Staphylococcus aureus Isolates(2022-04-01T00:00:00Z) Ceylan, Ayse Nur; SÜMBÜL, BİLGE; DOYMAZ, Mehmet Ziya; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYAObjective: The diagnosis and treatment of mecC positive methicillin resistant Staphylococcus aureus (MRSA) isolates pose a significant problem in clinical microbiology and infectious disease practices. The studies on the frequency of mecC positive isolates in Turkey is rather scarce. In the present study, we aimed to investigate the presence of mecA, mecC, spa and pvu genes in MRSA strains isolated from various clinical specimens submitted to Clinical Microbiology Laboratories of Bezmialem Vakıf Hospital. Methods: We performed nucleic acid extraction and multiplex polymerase chain reaction (PCR) to 126 MRSA strains to detect mecC, mecA, spa and pvl genes. Results: According to the multiplex PCR results of 126 MRSA strains studied, 126 (100%) had mecA, 107 (85%) had spa, and 3 (2%) had pvl genes. We performed another polymerase chain reaction protocol and spa genes were identified in 19 of specimens, which were found negative priorly. Conclusion: Considering the factors that a university medical center where the study was conducted provided a tertiary healthcare service to a large metropolitan area in Istanbul and none of the isolates carried mecC gene might indicate that mecC gene carrying MRSA isolates did not pose a significant public health threat in Turkey.Publication Metadata only Perfore apandisit: Etkenlerin ve enfeksiyon belirteçlerinin klinik iyileşme ve antibiyotik seçimine etkisi(2017-10-28) MIRAPOGLU, S. L.; AYDOĞDU, İBRAHİM; TÜREL, ÖZDEN; ÇAY, ALİ; GÜLTEPE, BİLGE; AYDOĞDU, İBRAHİM; TÜREL, ÖZDEN; ÇAY, ALI; SÜMBÜL, BİLGEPublication Metadata only Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis(2016-04-01T00:00:00Z) Dilek, Fatih; ÖZKAYA, EMİN; Gultepe, Bilge; YAZICI, MEBRURE; Iraz, Meryem; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRUREObjectives: There is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.Publication Metadata only Antibiotic resistance patterns of Escherichia Coli strains isolated from urine cultures İdrar kültürlerinden izole edilen Escherichia coli suşlari’nin antibiyotik direnç paterni(2014-01-01) IRAZ, Meryem; Gültepe, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZIYAPublication Metadata only Koneman Renkli Atlas ve Tanısal Mikrobiyoloji Kitabı(2017-01-01) GÜLTEPE, BİLGE; SÜMBÜL, BİLGEPublication Open Access Sonication of explants enhances the diagnostic accuracy of synovial fluid and tissue cultures and can help determine the appropriate antibiotic therapy for prosthetic joint infections.(2022-01-24T00:00:00Z) ALIYEV, ORKHAN; YILDIZ, FATİH; KAYA, HAKAN BATUHAN; Aghazada, AGHAMAZAHIR; SÜMBÜL, BİLGE; Citak, Mustafa; TUNCAY, İBRAHİM; ALIYEV, ORKHAN; YILDIZ, FATİH; KAYA, HAKAN BATUHAN; AGHAZADAA, AGHAMAZAHIR; SÜMBÜL, BİLGE; TUNCAY, İBRAHİMPurposes This study aimed to evaluate the sensitivity and specificity of the sonication cultures according to the International Consensus Meeting 2018 criteria and to evaluate the effect of sonication on the antibiotic treatment of patients.Publication Metadata only Kistik fibrozis dışı bronşektazide bronkoskop, mikrobiyoloji ve radyoloji ilişkisi(2017-04-09) ÇAKIR, ERKAN; Atabek, Ayşe Ayzıt; DASKAYA, HAYRETTİN; GEDIK, AH; Bilgin, Şennur; ıraz, meryem; GULTEPE, B; UMUTOGLU, T; ÇAKIR, ERKAN; DAŞKAYA, HAYRETTİN; SÜMBÜL, BİLGE