2020-09-01T00:00:00Z, DOGANAY, ÖZGE, ALKAN, ALPER, DİKER, NURETTİN, ATASOY, SEZEN, DOĞANAY, ÖZGE, ATASOY, SEZEN, DİKER, NURETTİN, ALKAN, ALPER

2021-12-02T00:00:00Z, Atasoy, Sezen, Göncü, Beyza Servet, Erdem, Gülsah, Omurtag Özgen, Pınar Sinem, Dağ, Aydan, ATASOY, SEZEN, GÖNCÜ, BEYZA SERVET, DAĞ, AYDAN

2020-03-25T00:00:00Z, Omurtag Ozgen, Pinar Sinem, Zengin Kurt, Belma, Atasoy, SEZEN, Durmus, Zehra, Yigit, Gülşah, Dağ, Aydan, ATASOY, SEZEN, ZENGİN KURT, BELMA, DAĞ, AYDAN

Carbon-based nanomaterials (CNMs) have attracted great attention in biomedical applications such as cancer imaging and therapy. CNMs, which are currently used in a wide range of applications, suffer from drawbacks of toxicity and low biocompatibility. Either noncovalent or covalent functionalization of CNMs with hydrophilic and biocompatible polymers which help to block hydrophobic interactivity between CNMs and cells can greatly increase their biocompatibility by eliminating their probable toxicity towards living organisms. In this report, we present a comparison of both noncovalent and covalent functionalization approaches in order to introduce a biocompatible glycoblock copolymer onto multi-walled carbon nanotubes (CNTs) in order to enhance their potential in therapies. An anticancer drug (doxorubicin, Dox) was conjugated with two different end functionalized poly(1-O-methacryloyl-beta-d-fructopyranose-b-(2-methacryloxyethoxy))benzaldehyde glycoblock copolymers, which were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, by either noncovalent or covalent tethering. CNTs were coated separately with the synthesized drug-conjugated glycoblock copolymers and folic acid (FA) to obtain an efficient drug delivery platform for dual-targeting of glucose transporter protein (GLUT5) and folic acid receptors (FR) in breast cancer. A library of synthesized monomers, polymers and prepared glycoblock copolymer coated CNTs (hybrid-CNTs) using both approaches were comprehensively characterized by various techniques. Transmission electron microscopy measurements showed the homogeneous, smooth morphology of the prepared Dox-conjugated glycoblock copolymer coating of CNTs and confocal laser scanning microscopy images displayed successful cellular internalization of hybrid-CNTs in the MCF-7 and MDA-MB-231 human breast cancer cell lines. This research demonstrates the potential of hybrid-CNTs as a biocompatible drug delivery system as well as in vitro use of Dox-conjugated vehicles for dual receptor mediated breast cancer therapy.

2021-02-01T00:00:00Z, Dağ, Aydan, Cakilkaya, Eda, Omurtag Özgen, Pınar Sinem, Atasoy, Sezen, Yiğit Erdem, Gulsah, Çetin, Büşra, Gürek, Ayşe Gül, DAĞ, AYDAN, ATASOY, SEZEN

2019-12-19, Dağ, Aydan, Topçu, Gülaçtı, Atasoy, Sezen, Aktaş, Asude Sena, Şenol, Halil, ŞENOL, HALIL, DAĞ, AYDAN, ATASOY, SEZEN, TOPÇU, GÜLAÇTI

2017-10-30, Atasoy, Sezen, Dağ, Aydan, DAĞ, AYDAN, ATASOY, SEZEN

2019-12-19, Şenol, Halil, Atasoy, Sezen, Güzeldemirci, Nuray, ŞENOL, HALIL, ATASOY, SEZEN

2017-10-02, Dağ, Aydan, DAĞ, AYDAN, ATASOY, SEZEN

2021-08-01T00:00:00Z, SEVGİ, ECE, DAĞ, AYDAN, Kizilarslan-Hancer, Cagla, ATASOY, SEZEN, ZENGİN KURT, BELMA, Aksakal, Oznur, SEVGİ, ECE, DAĞ, AYDAN, KIZILARSLAN HANÇER, ÇAĞLA, ATASOY, SEZEN, ZENGİN KURT, BELMA

Ethnopharmacological relevance: Dittrichia viscosa (L.) Greuter (& ldquo;Sari ot, Yapis & cedil;kan andiz otu & rdquo; in Turkish) is a medicinal plant that has been traditionally used in the Mediterranean area. This plant is used by the local population for the treatment of cancer. Investigation of their biological activities is therefore very important to be supported by scientific basis for traditional use.

2016-10-01T00:00:00Z, Atasoy, Sezen, Erturan, Salih Serdar, Yilmaz, Nail, Kuru, Dilhan, Cirakoglu, Ayse, Yilmaz, Sukriye, Deviren, Ayhan, ATASOY, SEZEN

OBJECTIVES: Multiple genetic changes are observed in malignant tumors but are rare or absent in benign conditions. Aneuploidy is the most common feature of solid tumors including lung cancer and diagnosis of malignant tumors is possible through detection of aneuploidy. The aim of this study was to investigate chromosomal abnormalities in cells from non-small cell lung cancer patients obtained bronchoscopically and to evaluate the suitability of fluorescence in situ hybridization (FISH).