Person: ATASOY, SEZEN
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Publication Metadata only Hedefli ilaç/gen içeren biyonanoprobların hazırlanması ve tedavi edici potansiyellerinin araştırılması(2021-12-02T00:00:00Z) Atasoy, Sezen; Göncü, Beyza Servet; Erdem, Gülsah; Omurtag Özgen, Pınar Sinem; Dağ, Aydan; ATASOY, SEZEN; GÖNCÜ, BEYZA SERVET; DAĞ, AYDANPublication Metadata only Evaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine(2021-08-01T00:00:00Z) SEVGİ, ECE; DAĞ, AYDAN; Kizilarslan-Hancer, Cagla; ATASOY, SEZEN; ZENGİN KURT, BELMA; Aksakal, Oznur; SEVGİ, ECE; DAĞ, AYDAN; KIZILARSLAN HANÇER, ÇAĞLA; ATASOY, SEZEN; ZENGİN KURT, BELMAEthnopharmacological relevance: Dittrichia viscosa (L.) Greuter (& ldquo;Sari ot, Yapis & cedil;kan andiz otu & rdquo; in Turkish) is a medicinal plant that has been traditionally used in the Mediterranean area. This plant is used by the local population for the treatment of cancer. Investigation of their biological activities is therefore very important to be supported by scientific basis for traditional use.Publication Metadata only Glycopolymer decorated multiwalled carbon nanotubes for dual targeted breast cancer therapy.(2020-03-25T00:00:00Z) Omurtag Ozgen, Pinar Sinem; Zengin Kurt, Belma; Atasoy, SEZEN; Durmus, Zehra; Yigit, Gülşah; Dağ, Aydan; ATASOY, SEZEN; ZENGİN KURT, BELMA; DAĞ, AYDANCarbon-based nanomaterials (CNMs) have attracted great attention in biomedical applications such as cancer imaging and therapy. CNMs, which are currently used in a wide range of applications, suffer from drawbacks of toxicity and low biocompatibility. Either noncovalent or covalent functionalization of CNMs with hydrophilic and biocompatible polymers which help to block hydrophobic interactivity between CNMs and cells can greatly increase their biocompatibility by eliminating their probable toxicity towards living organisms. In this report, we present a comparison of both noncovalent and covalent functionalization approaches in order to introduce a biocompatible glycoblock copolymer onto multi-walled carbon nanotubes (CNTs) in order to enhance their potential in therapies. An anticancer drug (doxorubicin, Dox) was conjugated with two different end functionalized poly(1-O-methacryloyl-beta-d-fructopyranose-b-(2-methacryloxyethoxy))benzaldehyde glycoblock copolymers, which were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, by either noncovalent or covalent tethering. CNTs were coated separately with the synthesized drug-conjugated glycoblock copolymers and folic acid (FA) to obtain an efficient drug delivery platform for dual-targeting of glucose transporter protein (GLUT5) and folic acid receptors (FR) in breast cancer. A library of synthesized monomers, polymers and prepared glycoblock copolymer coated CNTs (hybrid-CNTs) using both approaches were comprehensively characterized by various techniques. Transmission electron microscopy measurements showed the homogeneous, smooth morphology of the prepared Dox-conjugated glycoblock copolymer coating of CNTs and confocal laser scanning microscopy images displayed successful cellular internalization of hybrid-CNTs in the MCF-7 and MDA-MB-231 human breast cancer cell lines. This research demonstrates the potential of hybrid-CNTs as a biocompatible drug delivery system as well as in vitro use of Dox-conjugated vehicles for dual receptor mediated breast cancer therapy.Publication Metadata only Phthalocyanine-Conjugated Glyconanoparticles for Chemo-photodynamic Combination Therapy(2021-02-01T00:00:00Z) Dağ, Aydan; Cakilkaya, Eda; Omurtag Özgen, Pınar Sinem; Atasoy, Sezen; Yiğit Erdem, Gulsah; Çetin, Büşra; Gürek, Ayşe Gül; DAĞ, AYDAN; ATASOY, SEZENPublication Metadata only Synthesis of new fatty acid derivatives of oleanane and ursane triterpenoids and investigation of their in vitro cytotoxic effects on 3T3 fibroblast and PC3 prostate cancer cell lines(2020-09-01T00:00:00Z) Şenol, Halil; Çokuludağ, Kübra; Aktaş, Asude Sena; Atasoy, Sezen; Dağ, Aydan; Topçu, Gülaçtı; ŞENOL, HALIL; ATASOY, SEZEN; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Folic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release(2020-08-17T00:00:00Z) Birlik Demirel, Gokcen; Aygul, Ebru; DAĞ, AYDAN; ATASOY, SEZEN; Cimen, Zeynep; Cetin, Busra; DAĞ, AYDAN; ATASOY, SEZEN© 2020 American Chemical Society.Stimuli-sensitive and multifunctional nanoparticles are highly desirable biomedical materials for triggered and targeted drug delivery applications. Here, we have designed pH- A nd redox-triggered magnetic lipid-polymer hybrid nanoparticles (MHNPs) with a core-shell structure. This design is composed of a silica-/mesoporous silica-coated ellipsoidal magnetic nanoparticle with multifunctionality: Carrying the anticancer drug (doxorubicin, DOX), the cancer cell targeting ligand (folic acid-conjugated poly(ethylene glycol), FA-PEG) polymer, and being coated with a biocompatible pH-/redox-responsive (poly-l-histidine-poly(ethylene glycol)-lipoic acid; PLH-PEG-LA) polymer. The lipoic acid units of the PLH-PEG-LA shell of the FA-MHNPs were cross-linked using 1,4-dithiothreitol (DTT). When the FA-MHNPs-DOX were exposed to an endolysosomal pH of 5.5 and 10 mM glutathione (GSH), the particles exhibited a very efficient DOX release profile within 24 h. In addition, cytotoxicity, uptake, and apoptosis assays were performed against breast cancer cell lines. These results showed that FA-MHNPs-DOX promote an enhanced uptake and cell morbidity compared to the nontargeted MHNPs-DOX against tested cell lines. Moreover, the FA-MHNPs-DOX exhibited very effective cytotoxicity and also decreased the cell viability through apoptosis against breast cancer cell lines. In conclusion, it can be said that the pH and redox dual-responsive hybrid FA-MHNPs-DOX has a great potential for controlled drug release.Publication Metadata only Biological activities of extracts from Lavandula officinalis and Valeriana officinalis: Immunoregulation and cytotoxicity evaluation(2020-10-07T00:00:00Z) YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; KAPTAN, EYLÜL ZEYNEP; DAĞ, AYDAN; YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; DAĞ, AYDANPublication Metadata only Sulforaphane, a Chemopreventive Compound Induces Necrotic Behavior and Inhibits S-phase of Cell Cycle in Human Kidney Cells in Vitro(2023-03-01) Gökay G.; Göncü B. S.; Atasoy S.; Özten Kandaş N.; Dağ A.; GÖNCÜ, BEYZA SERVET; ATASOY, SEZEN; DAĞ, AYDAN