Person: ATASOY, SEZEN
Now showing 1 - 4 of 4
- PublicationMetadata onlyEvaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine(2021-08-01T00:00:00Z) SEVGİ, ECE; DAĞ, AYDAN; Kizilarslan-Hancer, Cagla; ATASOY, SEZEN; ZENGİN KURT, BELMA; Aksakal, Oznur; SEVGİ, ECE; DAĞ, AYDAN; KIZILARSLAN HANÇER, ÇAĞLA; ATASOY, SEZEN; ZENGİN KURT, BELMAEthnopharmacological relevance: Dittrichia viscosa (L.) Greuter (& ldquo;Sari ot, Yapis & cedil;kan andiz otu & rdquo; in Turkish) is a medicinal plant that has been traditionally used in the Mediterranean area. This plant is used by the local population for the treatment of cancer. Investigation of their biological activities is therefore very important to be supported by scientific basis for traditional use.
- PublicationMetadata onlyThe cytotoxicity of Biodentine modified with nanosized bioactive glass particles(2019-04-27T00:00:00Z) YUCA, TUĞÇE; ZENGİN KURT, BELMA; ATASOY, SEZEN; DAĞ, AYDAN; GÜNEŞER, MEHMET BURAK; ZENGİN KURT, BELMA; ATASOY, SEZEN; DAĞ, AYDAN; GÜNEŞER, MEHMET BURAK
- PublicationMetadata onlyFolic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release(2020-08-17T00:00:00Z) Birlik Demirel, Gokcen; Aygul, Ebru; DAĞ, AYDAN; ATASOY, SEZEN; Cimen, Zeynep; Cetin, Busra; DAĞ, AYDAN; ATASOY, SEZEN© 2020 American Chemical Society.Stimuli-sensitive and multifunctional nanoparticles are highly desirable biomedical materials for triggered and targeted drug delivery applications. Here, we have designed pH- A nd redox-triggered magnetic lipid-polymer hybrid nanoparticles (MHNPs) with a core-shell structure. This design is composed of a silica-/mesoporous silica-coated ellipsoidal magnetic nanoparticle with multifunctionality: Carrying the anticancer drug (doxorubicin, DOX), the cancer cell targeting ligand (folic acid-conjugated poly(ethylene glycol), FA-PEG) polymer, and being coated with a biocompatible pH-/redox-responsive (poly-l-histidine-poly(ethylene glycol)-lipoic acid; PLH-PEG-LA) polymer. The lipoic acid units of the PLH-PEG-LA shell of the FA-MHNPs were cross-linked using 1,4-dithiothreitol (DTT). When the FA-MHNPs-DOX were exposed to an endolysosomal pH of 5.5 and 10 mM glutathione (GSH), the particles exhibited a very efficient DOX release profile within 24 h. In addition, cytotoxicity, uptake, and apoptosis assays were performed against breast cancer cell lines. These results showed that FA-MHNPs-DOX promote an enhanced uptake and cell morbidity compared to the nontargeted MHNPs-DOX against tested cell lines. Moreover, the FA-MHNPs-DOX exhibited very effective cytotoxicity and also decreased the cell viability through apoptosis against breast cancer cell lines. In conclusion, it can be said that the pH and redox dual-responsive hybrid FA-MHNPs-DOX has a great potential for controlled drug release.
- PublicationMetadata onlyBiological activities of extracts from Lavandula officinalis and Valeriana officinalis: Immunoregulation and cytotoxicity evaluation(2020-10-07T00:00:00Z) YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; KAPTAN, EYLÜL ZEYNEP; DAĞ, AYDAN; YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; DAĞ, AYDAN