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Now showing 1 - 10 of 18
  • PublicationMetadata only
    A Case of Multiple Familial Trichoepitelioma with Malignant Transformation Successfully Treated with Vismodegib.
    (2020-05-13T00:00:00Z) Cengiz, Fatma Pelin; Kelahmetoglu, Osman; Yildiz, P; Tekce, E; Akarslan, Tc; Shbair, A; Seker, M; Onsun, N; KELAHMETOĞLU, OSMAN; YILDIZ, PELİN; YENİGÜN, ALPER; TEKÇE, ERTUĞRUL
  • PublicationMetadata only
  • PublicationMetadata only
    Current Approach to the Prognostic Parameters of Testicular Germ Cell tumors Accompanied by Our Cases
    (2020-08-01T00:00:00Z) Çoban, Ganime; Yıldız, Pelin; Sezal, Zeynep; Adıllı, Adile; Beşiroğlu, Mehmet; Akçay, Muzaffer; Gücin, Zühal; ÇOBAN, GANİME; YILDIZ, PELİN; BEŞİROĞLU, MEHMET; AKÇAY, MUZAFFER; GÜCİN, ZÜHAL
  • PublicationMetadata only
    Histopathological Features of Paratesticular Solid Tumors: 5 Years Experience
    (2020-05-01T00:00:00Z) Çoban, Ganime; Yıldız, Pelin; Kıran, Tuğçe; Ersöz, Cevper; ÇOBAN, GANİME; YILDIZ, PELİN; KIRAN, TUĞÇE; ERSÖZ, CEVPER
  • PublicationOpen Access
    Merkel Cell Carcinoma
    (2023-01-01) Sönmez Ergün, Selma ; Kirazoğlu, Ahmet; Akdemir, Osman Cemil; Su Küçük, Özlem; Altınok, Pelin; Yıldız, Pelin; ERGÜN, SELMA; AKDEMİR, OSMAN CEMİL; KİRAZOĞLU, AHMET; YILDIZ, PELİN; SU KÜÇÜK, ÖZLEM; ALTINOK SÜT, PELİN
    Merkel cell carcinoma (MCC) is a rare tumor that arises from mechanoreceptor Merkel cells. Ultraviolet exposure, immunosuppression and Merkel cell polyoma virus play a significant role in tumor pathogenesis. Although it typically presents as an initially indolent growing, painless solitary lesion, the course of MCC may be aggressive due to the nodal invasion, distant metastasis and high recurrence rates. We presented a case of MCC with a background history of rheumatoid arthritis treated with immunosuppressive therapy for many years who had necrotizing granulomatous lymphadenitis.
  • PublicationMetadata only
    The role of diffusion-weighted MRI and contrast-enhanced MRI for differentiation between solid renal masses and renal cell carcinoma subtypes
    (2020-09-01T00:00:00Z) Serter, Asli; ONUR, MEHMET RUHİ; ÇOBAN, Ganime; YILDIZ, PELİN; Armagan, Abdullah; Kocakoc, Ercan; ÇOBAN, GANİME; YILDIZ, PELİN
    Purpose To assess the value of diffusion-weighted magnetic resonance imaging (DW-MRI) and contrast-enhanced MRI (CE-MRI) for differentiation between benign and malignant solid renal masses, renal cell carcinoma (RCC) subtypes, oncocytomas, and lipid-poor angiomyolipomas (LP-AML). Methods Minimum or lowest -apparent diffusion coefficient- (ADC(1)) and representative ADC values (ADC(2)) of 112 renal masses (n: 46 benign renal mass,n: 66 malignant renal mass) were measured on DW-MRI images (b50, 400, 800 s/mm(2)). Signal intensity (SI) measurements were performed in normal renal parenchyma and most avid enhanced area of the renal masses at precontrast, corticomedullary, and nephrographic phases on CE-MRI. Contrast enhancement rate (CER) and contrast enhancement index (CEI) values of renal masses were compared between benign-malignant renal masses and RCC subtypes, oncocytomas, and LP-AMLs. Results There was no significant difference between ADC(1), ADC(2)values, and SI of benign and malignant renal masses (p = 0.721,p = 0.255,p = 0.872). Mean ADC(1)and ADC(2)values of clear cell RCCs were significantly higher than nonclear cell RCCs (p = 0.005p = 0.002). Mean CER value of clear cell RCCs was significantly higher than nonclear cell RCCs in nephrographic phase (p = 0.003). Mean CEI values of clear cell RCCs were significantly higher than nonclear cell RCCs in the corticomedullary and nephrographic phase (p = 0.027 vs. 0.008). LP-AMLs were differentiated from other renal masses with wash-out phenomenon. Conclusion Combined usage of ADC, SI, CER, and CEI values may be useful for discrimination between RCC subtypes, oncocytomas, and lipid-poor AMLs.
  • PublicationMetadata only
    Mesane Tümörleri
    (2021-01-01T00:00:00Z) YILDIZ, PELİN; YILDIZ, PELİN
  • PublicationMetadata only
    Challenges in early diagnosis of primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma: a case series of four patients.
    (2020-08-01T00:00:00Z) Akaslan, TÇ; Dizman, D; Emiroğlu, N; Tosuner, Z; Çetin, G; Demirkesen, C; ONSUN, NAHIDE; YILDIZ, PELİN; ÇETİN, GÜVEN
    Background: Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (AECTCL) is a rare and aggressive lymphoma characterised by ulcerated lesions and a poor prognosis. Objectives: To present a case series of four previously misdiagnosed AECTCL patients and discuss the importance of early diagnosis. Materials and methods: All patients in this study were identified from the database of the Dermatology Department of the Medical School of Bezmialem Vakif University, based on clinical and histopathological diagnosis of AECTCL between 2010 and 2018. Results: AECTCL cases may mimic many benign dermatoses and accurate diagnosis may be delayed. Conclusion: Because of its poor prognosis, early diagnosis of AECTCL may be helpful in improving the likelihood of patient survival, but further study is needed to address the challenges in diagnosing this rare and aggressive lymphoma.
  • PublicationMetadata only
    Analysis of interobserver reproducibility in grading dysplastic nevi: Results of the application of the 2018 World Health Organization grading criteria
    Background We aimed to determine whether the histopathological grading of dysplastic nevi is an objective endeavor, considering interobserver variability, according to 2018 World Health Organization (WHO) criteria. Methods In total, 179 cases of dysplastic nevi, with high and moderate degree of atypia, diagnosed and graded according to the previous criteria were reviewed by three pathologists. Then, the observers graded the dysplastic nevi as low or high according to 2018 WHO criteria. Results Grading of dysplastic nevi was in complete agreement in 99 out of 179 cases across three observers with a fair level of overall interobserver agreement (multirater kappa(free): 0.40). The observers showed moderate to good agreement for most of the architectural features, except for criteria regarding focal continuous basal proliferation of melanocytes, density of non-nested junctional melanocytes, and presence of dyscohesive nests of intraepidermal melanocytes, whereas fair agreement was achieved for the cytological criteria. Conclusions The 2018 WHO criteria for dysplastic nevus will ensure a common approach to the diagnosis and grading of dysplastic nevi. However, histopathological criteria, such as cytological features and focal continuous basal proliferation of melanocytes, should be improved so as to ensure a more accurate surgical approach and risk assessment.
  • PublicationMetadata only
    Oral liken planus ve skuamöz hücreli karsinom olgularında Langerhans hücre yoğunluğunun değerlendirilmesi