Person: KORKMAZ, LEVENT
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Publication Metadata only Neonatal diabetes in an infant of a diabetic mother: same novel INS missense mutation in the mother and her offspring(2014-07-01T00:00:00Z) Öztürk, Mehmet Adnan; Kurtoglu, Selim; Bastug, Osman; KORKMAZ, LEVENT; Daar, Ghaniya; Memur, Seyma; Halis, Hulya; GÜNEŞ, TAMER; Hussain, Khalid; Ellard, Sian; KORKMAZ, LEVENTNeonatal diabetes is defined as an uncontrolled hyperglycemic state occurring within the first 6 months of life. It is a rare disease with an incidence of 1 to 90,000-250,000. It is usually a disease of genetic origin in which insulin gene mutations play the main role in the disease process. A baby, born to a mother who had previously been diagnosed with type 1 diabetes mellitus at 14 months of age, had a high blood sugar level within the first few hours after birth and was subsequently diagnosed as having neonatal diabetes mellitus. Baby and mother were identified as having a novel heterozygous insulin missense mutation, p.C109R. Difficulties occurred in both follow-up and feeding of the baby. Without the addition of the mother-s milk, an appropriate calorie milk formula and isophane insulin were used for the baby during follow-up. Multiple mechanisms are responsible in the pathogenesis of neonatal diabetes mellitus. Insulin gene mutations are one of the factors in the development of neonatal diabetes mellitus. If a resistant hyperglycemic state persists for a long time among babies, especially in those with intra-uterine growth retardation whose mothers are diabetic, the baby concerned should be followed-up carefully for the development of neonatal diabetes mellitus.Publication Metadata only Short-term Refractive Effects of Propranolol Hydrochloride Prophylaxis on Retinopathy of Prematurity in Very Preterm Newborns(2018-01-01T00:00:00Z) Korkmaz, LEVENT; KARACA, Çağatay; Akın, Mustafa Ali; Bastug, Osman; Sahiner, Mustafa; Ozdemir, Ahmet; GÜNEŞ, Tamer; ÖZTÜRK, Mehmet Adnan; Kurtoglu, Selim; KORKMAZ, LEVENTPurpose: Retinopathy of prematurity (ROP) is one of the major problems of surviving premature infants with several ophthalmic morbidities such as increased risk of refractive errors, strabismus, and cortical visual impairment. Use of propranolol hydrochloride (PH) for the prevention of ROP is a new promising treatment modality. However, long-term effects are still to be defined. In our study, we aimed to investigate the short-term refractive effects of PH used for ROP prophylaxis in very preterm newborns.Publication Metadata only Effect of Iodine Loading on the Thyroid Hormone Level of Newborns Living in Kayseri Province(2014-12-01T00:00:00Z) Kurtoglu, Selim; Bastug, Osman; Daar, Ghaniya; Halis, Hulya; Korkmaz, Levent; Memur, Seyma; Korkut, Sabriye; GÜNEŞ, TAMER; ÖZTÜRK, MEHMET ADNAN; KORKMAZ, LEVENTIntroduction Excessive iodine exposure during the fetal and neonatal periods can lead to neonatal hypothyroidism. This study was conducted to evaluate the level of iodine loading among newborns living in Kayseri province. A total of 59 newborns, who were admitted due to disorders in thyroid hormone levels, were included in the study.Publication Metadata only Ovarian hyperstimulation syndrome treated by medroxyprogesterone acetate(2014-09-01T00:00:00Z) Halis, Hulya; Memur, Seyma; Korkmaz, Levent; Bastug, Osman; GÜNEŞ, TAMER; Kurtoglu, Selim; KORKMAZ, LEVENTThe activation of the hypothalamic-pituitary-gonadal axis observed during the first month of life is thought to be a significant phase in the maturation of gonads and potentially be important for the development of reproductive functions. The preterm ovarian hyperstimulation syndrome (POHS) was first detected at postconception 36-39 weeks in a preterm female newborn with edema developing in the vulva, the hypogastric site, and the upper leg. The pathophysiology of this postnatal hormonal change is obscure. In this paper we would like to present a case developing POHS and to discuss possible pathophyslogical mechanisms.