Person: ERCAN, ÇİLEM
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Publication Open Access Parathyroid Allotransplant With a New Technique: A Prospective Clinical Trial.(2016-08-01) Aysan, E; ALTUG, B; ERCAN, C; Kesgin, Toka; IDIZ, UO; MUSLUMANOGLU, M; AYŞAN, MUSTAFA ERHAN; ERCAN, ÇİLEMObjectives: Parathyroid allotransplant is a valuable alternative in treating permanent hypoparathyroidism. However, it is a difficult process that requires several trained staff and advanced laboratory equipment, which makes the costs high. Here, we identify a new parathyroid allotransplant technique. Materials and Methods: After obtaining informed consent from patients, parathyroid cell suspensions obtained from 4 donors who had undergone a subtotal parathyroidectomy owing to chronic renal failure were transplanted in 10 patients with permanent hypoparathyroidism after short-term cell cultivation. Prednisolone were used as immunosuppressant for the first 10 days and discontinued thereafter. Results: Allograft function was observed in 7 patients (70%) at a mean follow-up of 12 months. Daily oral calcium and vitamin D supplementations discontinued totally in 7 patients. No major or minor complication was observed. Conclusions: Our technique is simple, fast, and has a low cost, with a 70% success rate at a mean follow-up of 12 months. It requires few staff, minimal equipment, and short-term immunosuppressant use for main tenance. The technical developments of parathyroid allotransplant, as mentioned in this study, may be important in treating permanent hypoparathyroidismPublication Open Access Parathyroid Allotransplant for Persistent Hypocalcaemia: A New Technique Involving Short-Term Culture.(2016-04-01) Aysan, E; KILIC, U; GOK, O; ALTUG, B; ERCAN, C; Kesgin, Toka; IDIZ, UO; MUSLUMANOGLU, M; AYŞAN, MUSTAFA ERHAN; ERCAN, ÇİLEMObjectives: To develop a new parathyroid allotransplant method for the treatment of permanent hypoparathyroidism. Materials and methods: Parathyroid cells 50 × 10(6) derived from a parathyroid hyperplasia patient were transferred to a 61-year-old patient who had thyroidectomy 17 years earlier, allowing to papillary thyroid cancer; he was admitted to our outpatient clinic with symptomatic chronic hypocalcemia. Cell isolation, cryopreservation, and culturing were conducted according to a new protocol. Results: During a follow-up of 5 months, the patient had no complications that could indicate rejection, and clinical symptoms completely resolved without requiring any drug supplementation. Conclusions: Here, we report a new method, enabling fast and cost-effective parathyroid allotransplant with maintained tissue viability sufficient to treat persistent hypocalcemia.Publication Metadata only A novel non-surgical, minimally invasive technique for parathyroid autotransplantation: a case report.(2015-03-01) Aysan, E; KILIC, U; GOK, O; ALTUG, B; ERCAN, C; IDIZ, UO; KESGIN, C; MUSLUMANOGLU, M; AYŞAN, MUSTAFA ERHAN; ERCAN, ÇİLEM