Person: ÇAKIR, FATMA BETÜL
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- PublicationOpen AccessPersistent pleural effusion in an infant with an unusual diagnosis: congenital alveolar rhabdomyosarcoma(2020-01-01T00:00:00Z) Yozgat, Can Yilmaz; YEŞİLBAŞ, Osman; YOZGAT, Yılmaz; AKDEMİR, OSMAN CEMİL; YURTSEVER, İsmail; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, Şahande; ÇAKIR, FATMA BETÜL; YEŞİLBAŞ, OSMAN; YOZGAT, YILMAZ; AKDEMİR, OSMAN CEMİL; YURTSEVER, İSMAİL; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, ŞAHANDE; ÇAKIR, FATMA BETÜLRhabdomyosarcoma (RMS) is a malignant form of neoplasm that originates from skeletal muscle. RMSs can exist anywhere in the human body but are more commonly detected in the neck region and extremities. The alveolar type is one of the subtypes of RMS that has a poor prognosis. Because the clinical manifestation of a tumour can be a painless mass, symptoms might be non-contributary to the diagnosis. Herein, a four-month-old girl was admitted to the emergency department with complaints of respiratory distress without a runny nose, cough, and fever. Recurrent effusions subsided with subsequent tube thoracostomy. Video-assisted thoracoscopic surgery (VATS) was performed to determine the aetiology of the recurrent effusion. The Tru-Cut biopsy obtained during VATS resulted in the diagnosis of alveolar rhabdomyosarcoma. Pleural effusion decreased, and the tube drainage was stopped rapidly after first vincristine, actinomycin-D, and cyclophosphamide chemotherapy cycle. Persistent and recurrent pleural effusions should alert physicians to rule out unusual diagnoses like that of our case.
- PublicationOpen AccessRelationships Between Bronchoscopy, Microbiology, and Radiology in Noncystic Fibrosis Bronchiectasis(2021-05-01T00:00:00Z) NURSOY, MUSTAFA ATİLLA; KILINÇ SAKALLI, Ayşe Ayzıt; ABDİLLAHİ, FATOUMA KHALİF; USTABAŞ KAHRAMAN, Feyza; Al Shadfan, Lina Muhammed; SÜMBÜL, BİLGE; Bilgin, Sabriye Sennur; ÇAKIR, FATMA BETÜL; DAŞKAYA, HAYRETTİN; ÇAKIR, Erkan; NURSOY, MUSTAFA ATİLLA; ABDİLLAHİ, FATOUMA KHALİF; USTABAŞ KAHRAMAN, FEYZA; SÜMBÜL, BİLGE; ÇAKIR, FATMA BETÜL; DAŞKAYA, HAYRETTİN; ÇAKIR, ERKANBackground: Published data on the correlations of bronchoscopy findings with microbiological, radiological, and pulmonary function test results in children with noncystic fibrosis (CF) bronchiectasis (BE) are unavailable. The aims of this study were to evaluate relationships between Bronchoscopic appearance and secretion scoring, microbiological growth, radiological severity level, and pulmonary function tests in patients with non-CF BE. Methods: Children with non-CF BE were identified and collected over a 6-year period. Their medical charts and radiologic and bronchoscopic notes were retrospectively reviewed. Results: The study population consisted of 54 female and 49 male patients with a mean age of 11.7 ± 3.4 years. In the classification according to the bronchoscopic secretion score, Grade I was found in 2, Grade II in 4, Grade III in 9, Grade IV in 17, Grade V in 25, and Grade VI in 46 patients. When evaluated according to the Bhalla scoring system, 45 patients had mild BE, 37 had moderate BE, and 21 had severe BE. Microbial growth was detected in bronchoalveolar lavage fluid from 50 of the patients. Forced expiratory volume in 1 s (FEV1) and functional vital capacity decreased with increasing bronchoscopic secretion grade (P = 0.048 and P = 0.04), respectively. The degree of radiological severity increased in parallel with the bronchoscopic secretion score (P = 0.007). However, no relationship was detected between microbiological growth rate and radiological findings (P = 0.403). Conclusions: This study showed that bronchoscopic evaluation and especially scoring of secretions correlate with severe clinical condition, decrease in pulmonary function test, worsening in radiology scores, and increase in microbiological bacterial load in patients. Flexible endoscopic bronchoscopy should be kept in mind in the initial evaluation of non-CF BE patients.
- PublicationOpen AccessSurprise diagnosis in an adolescent case with chronic kidney damage: Questions.(2021-01-11T00:00:00Z) Doğan, Güzide; Akıncı, Nurver; Sharifov, Rasul; Çakır, Fatma Betül; Türk, HACI MEHMET; ÇAKIR, FATMA BETÜL; ŞENTÜRK, HAKAN; TÜRK, HACI MEHMETA 17-year-old male patient presented to the emergency room due to fatigue, severe right flank pain, and rectal bleeding that happened 3 months ago as well, and elevated serum creatinine (1.4 mg/dl), bilateral hydroureteronephrosis, and bilateral echogenic kidneys were detected at that time. Micturating cystourethrography revealed grade 2 vesicoureteral reflux (VUR) on the right. Scintigraphy revealed 66% functioning right kidney with a non-obstructive stasis and 34% functioning left kidney with poor perfusion and concentrating ability. With these findings, a diagnosis of chronic kidney damage (CKD) secondary to VUR was made. He had no previous urinary tract infection or symptoms of dysfunctional bladder. He had a laboratory examination 2 years ago which revealed normal urea (41 mg/dl) and creatinine (0.7 mg/dl) levels. He had no abdominal imaging before 3 months ago. In his family history, he had a cousin with a diagnosis of infantile myxoid mesenchymal tumor.
- PublicationOpen AccessEvaluation of diagnostic components and management of childhood pulmonary tuberculosis: a prospective study from Istanbul, Turkey.(2022-01-31T00:00:00Z) Dogan Demir, Aysegul; Kut, Arif; Ozaydin, Erhan; Cakir, Fatma Betul; Ustabas Kahraman, Feyza; Uzuner, Selcuk; Collak, Abdulhamit; Cakin, Zeynep Ebru; Cakir, Erkan; ÇAKIR, FATMA BETÜL; USTABAŞ KAHRAMAN, FEYZA; ERENBERK, UFUK; UZUNER, SELÇUK; ÇAKIR, ERKANIntroduction: The diagnosis of childhood tuberculosis is difficult and most of the patients are diagnosed clinically. The objective of this study is to reveal the diagnostic and therapeutic components of childhood pulmonary tuberculosis and to analyze the changes that occurred in our country over the years. Methodology: All patients diagnosed with tuberculosis between 2006 and 2016 were included. Demographic characteristics, diagnostic and treatment outcomes were recorded and patients were followed up prospectively. Results: A total of 492 patients were included in the study. 97% had Bacillus Calmette-Guerin vaccine, 36% were diagnosed with microbiologically-confirmed tuberculosis and 64% were diagnosed with clinically-proven tuberculosis. 94% of the patients had symptoms consistent with tuberculosis, all patients had radiologic findings, 74% had a history of tuberculosis contact and 63% had tuberculin skin test positivity. The diagnoses included primary tuberculosis in 62%, secondary tuberculosis in 21%, progressive primary tuberculosis in 13% and miliary tuberculosis in 4%. 48% of the patients received a treatment regimen containing three drugs as the initial treatment, and drug-related side effects developed in 12%. Isoniazid resistance was detected in 13% of the patients and rifampicin resistance was detected in 8%. None of the patients died due to tuberculosis. In the last 50 years in Turkey, the rates of Bacillus Calmette-Guerin vaccination and diagnosis of tuberculosis cases have increased and the mortality rates have decreased over the years. Conclusions: Our study is one of the few prospective studies and revealed the differences between the recent data and the past 50 years in childhood tuberculosis in Turkey.
- PublicationOpen AccessSurprise diagnosis in an adolescent case with chronic kidney damage: Answers.(2021-01-11T00:00:00Z) Doğan, Güzide; Akıncı, Nurver; Sharifov, Rasul; Şentürk, Hakan; Türk, HACI MEHMET; ÇAKIR, FATMA BETÜL; ŞENTÜRK, HAKAN; TÜRK, HACI MEHMET
- PublicationOpen AccessCeftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin(2016-03-01) Vehapoglu, AYSEL; GOKNAR, Nilufer; TUNA, Rumeysa; Cakir, FATMA BETÜL; VEHAPOĞLU TÜRKMEN, AYSEL; ÇAKIR, FATMA BETÜLDrug-induced hemolytic anemia is an immune-mediated phenomenon that leads to the destruction of red blood cells. Here, we present a case of life-threatening ceftriaxone-induced hemolytic anemia (CIHA) in a previously healthy 3-year-old girl. We also reviewed the literature to summarize the clinical features and treatment of hemolytic anemia. Acute hemolysis is a rare side effect of ceftriaxone therapy associated with high mortality. Our patient had a sudden loss of consciousness with macroscopic hematuria and her hemoglobin dropped from 10.2 to 2.2 g/dl over 4 hours, indicating that the patient had life-threatening hemolysis after an intravascular dose of ceftriaxone who had previously been treated with ceftriaxone in intramuscular form for six days. CIHA is associated with a positive direct antiglobulin test, revealing the presence of IgG in all cases and C3d in most cases. Our patient's direct antiglobulin test was positive for IgG (3+) and for C3d (4+). The case was managed successfully with supportive measures and intravenous immunoglobulin therapy. Ceftriaxone is used very frequently in children; an early diagnosis and proper treatment of hemolytic anemia are essential to improve the patient outcome. The pathophysiological mechanism is the same as for non-drug autoimmune hemolytic anemia. However, there is still no consensus treatment for CIHA. Intravenous immunoglobulin can be used in clinical emergencies, such as our case, or in refractory cases.
- PublicationOpen AccessFalse positivity of magnetic resonance imaging under the effect of granulocyte-colony stimulating factor in a child with leukemia(2013-06-01) ÇAKIR, FATMA BETÜL; Baysal, Begümhan; Doğan, Öner; ÇAKIR, FATMA BETÜLGranulocyte-colony stimulating factor (G-CSF) increases the proliferation and maturation of committed polymorphonuclear leukocyte precursors, as well as the function of mature polymorphonuclear leukocytes. It has previously been shown in pediatric patients that G-CSF induces reconversion of fatty bone marrow to hematopoietic bone marrow in the pelvis and lower extremities that is detectable by magnetic resonance imaging (MRI). Here, we report a 13-year-old Burkitt leukemia patient with bone pain while he was in remission. He was on G-CSF after cessation of high-dose and low-dose cytarabine chemotherapy. He was suspected to have a leukemia relapse. Pelvic MRI was consistent with leukemic infiltration. However, the pathology of bone marrow biopsy resulted in normal findings. Thus it was suggested that concurrent administration of G-CSF could be the causative agent for both bone pain and false-positive MRI findings. The control MRI after interruption of G-CSF revealed normal findings. In conclusion, radiologists should be informed about the type of therapy, including G-CSF administration, in order to overcome misinterpretation of bone marrow MRI.
- PublicationOpen AccessDesmoplastic infantile ganglioglioma: Report of an unusual case with a cranial defect.(2014-01-01) BASARAN, RUZİYE; Cakir, FATMA BETÜL; ISIK, N; SAV, A; ELMACI, I; BAŞARAN, RUZİYE; ÇAKIR, FATMA BETÜL
- PublicationOpen AccessA Difficult Case of Hodgkin Lymphoma with Differential Diagnosis of Tuberculosis and Sarcoidosis.(2015-06-08) GÖKNAR, N; Çakır, FATMA BETÜL; KASAPCOPUR, O; YEGEN, G; GEDIK, AH; OKTEM, F; ÇAKIR, ERKAN; ÇAKIR, FATMA BETÜLWe report here the case of a 14-year-old boy with history of fever, weight loss, and mediastinal lymphadenopathy. The clinical symptoms and laboratory findings mimicking tuberculosis and sarcoidosis complicated the diagnostic process. He was diagnosed with Hodgkin's lymphoma after several X-rays, computed tomography, positron emission tomography-computed tomography, laboratory tests and three lymph node biopsy. Clinicians should be alerted on new lesions and symptoms in high risk patients and should repeat diagnostic tests and lymph node biopsies as indicated.