Person: ÇAKIR, FATMA BETÜL
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- PublicationMetadata onlyKanser Hastasında Kanıta Dayalı Palyatif Bakım – Konsensus 2017(2018-01-01T00:00:00Z) SAYGILI, ÜLKÜ; BIÇAK, DERYA; CAN, GÜLBEYAZ; Başıbüyük, Meryem; Ghrayeb, Ibtisam; Meron, Tikva; Özcan, Kezban; Bingöl, Hülya; KARABACAK, ÜKKE; Zadjali, Manal Al; ÇAKIR, FATMA BETÜL; ÇAKIR, FATMA BETÜL
- PublicationMetadata onlyEffect of Virtual Reality Exergaming on Function in Children with Brain Tumors: 3 Months Follow Training in 5 Case Series(2018-11-01T00:00:00Z) TANRIVERDİ, Müberra; Mutluay, F.; ÇAKIR, FATMA BETÜL; TANRIVERDİ, MÜBERRA; ÇAKIR, FATMA BETÜL
- PublicationMetadata onlyDIFFUSE INTRINSIC PONTINE GLIOMAS IN CHILDREN: RESULTS FROM A SINGLE CENTER(2012-12-01T00:00:00Z) Kebudi, Rejin; ÇAKIR, FATMA BETÜL; Agaoglu, Fulya Yaman; GÖRGÜN, Ömer Nafi Halil; Dizdar, Yavuz; Ayan, Inci; Darendeliler, Emin; ÇAKIR, FATMA BETÜL
- PublicationMetadata onlyCross-sectional study: long term follow-up care for pediatric cancer survivors in a developing country, Turkey: current status, challenges, and future perspectives(2020-01-01T00:00:00Z) Incesoy Ozdemir, Sonay; TAÇYILDIZ, NURDAN; VARAN, ALİ; KEBUDİ, Rejin; ZÜLFİKAR, Osman Bülent; Celkan, Tiraje; Sahin, Gurses; Corapcioglu, Funda; Keskin Yildirim, Zuhal; PINARLI, FARUK GÜÇLÜ; Olgun, Nur; Sari, Neriman; Dagdemir, Ayhan; Ozyoruk, Derya; Eren, Tuba; ÇAKIR, FATMA BETÜL; Adakli Aksoy, Basak; Bozkurt, Ceyhun; Guler, Elif; Ozguven, Ali Aykan; Erbey, Fatih; Berber, Melda; Dincaslan, Handan; Unal, Emel; Kantar, Mehmet; ÇAKIR, FATMA BETÜLAim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey.
- PublicationMetadata onlyPain management with Radiotherapy and ozone with high dose vitamin C therapy in a case of bone metastatis of breast cancer patient(2018-02-01) KIRSEVER, ESRA; KIZILTAN, HURİYE ŞENAY; YILMAZ, RABİYE; GÜNEŞ BAYIR, AYŞE; BAŞIBÜYÜK, MERYEM; ÇAKIR, FATMA BETÜL; GÜL, KÜRŞAT; ŞİMŞEK, MUHARREM; KIZILTEPE, AYŞE; GÜMÜŞ, ASLI; KALAYCI, KÜBRA; AKÇAKAYA, ADEM; MAYADAĞLI, ALPASLAN; AYDOĞDU, İBRAHİM; ALTINOK SÜT, PELİN; AYDIN, TEOMAN; KIZILTAN, HURİYE ŞENAY; ERİŞ, ALİ HİKMET; GÜNEŞ BAYIR, AYŞE; BAŞIBÜYÜK, MERYEM; ÇAKIR, FATMA BETÜL; GÜL, KÜRŞAT; GÜMÜŞ, ASLI; KALAYCI, KÜBRA; AKÇAKAYA, ADEM; MAYADAĞLI, ALPASLAN; AYDOĞDU, İBRAHİM; ALTINOK SÜT, PELİN; AYDIN, TEOMAN
- PublicationMetadata onlyİntramuskuler seftriakson sonrası akut intravasküler hemoliz gelişen bir olgu sunumu(2014-06-01T00:00:00Z) RÜMEYSA, TUNA; VEHAPOĞLU TÜRKMEN, Aysel; ÇAKIR, FATMA BETÜL; VEHAPOĞLU TÜRKMEN, AYSEL; ÇAKIR, FATMA BETÜL
- PublicationOpen AccessPersistent pleural effusion in an infant with an unusual diagnosis: congenital alveolar rhabdomyosarcoma(2020-01-01T00:00:00Z) Yozgat, Can Yilmaz; YEŞİLBAŞ, Osman; YOZGAT, Yılmaz; AKDEMİR, OSMAN CEMİL; YURTSEVER, İsmail; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, Şahande; ÇAKIR, FATMA BETÜL; YEŞİLBAŞ, OSMAN; YOZGAT, YILMAZ; AKDEMİR, OSMAN CEMİL; YURTSEVER, İSMAİL; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, ŞAHANDE; ÇAKIR, FATMA BETÜLRhabdomyosarcoma (RMS) is a malignant form of neoplasm that originates from skeletal muscle. RMSs can exist anywhere in the human body but are more commonly detected in the neck region and extremities. The alveolar type is one of the subtypes of RMS that has a poor prognosis. Because the clinical manifestation of a tumour can be a painless mass, symptoms might be non-contributary to the diagnosis. Herein, a four-month-old girl was admitted to the emergency department with complaints of respiratory distress without a runny nose, cough, and fever. Recurrent effusions subsided with subsequent tube thoracostomy. Video-assisted thoracoscopic surgery (VATS) was performed to determine the aetiology of the recurrent effusion. The Tru-Cut biopsy obtained during VATS resulted in the diagnosis of alveolar rhabdomyosarcoma. Pleural effusion decreased, and the tube drainage was stopped rapidly after first vincristine, actinomycin-D, and cyclophosphamide chemotherapy cycle. Persistent and recurrent pleural effusions should alert physicians to rule out unusual diagnoses like that of our case.
- PublicationMetadata onlyEffects of Malnutrition on Neutrophil/Mononuclear Cell Apoptotic Functions in Children with Acute Lymphoblastic Leukemia(2017-04-01) ÇAKIR, FATMA BETÜL; Berrak, Su Gülsün; Aydoğan, Gönül; Tulunay, Aysin; Timur, Cetin; Canpolat, Cengiz; ÇAKIR, FATMA BETÜLBackground: Recent studies claim that apoptosis may explain immune dysfunction observed in malnutrition. Objective: The objective of this study was to determine the effect of malnutrition on apoptotic functions of phagocytic cells in acute lymphoblastic leukemia (ALL). Materials and Methods: Twenty-eight ALL patients (13 with malnutrition) and thirty controls were enrolled. Neutrophil and mononuclear cell apoptosis of ALL patients and the control group were studied on admission before chemotherapy and repeated at a minimum of three months after induction of chemotherapy or when the nutritional status of leukemic children improved. Results: The apoptotic functions of both ALL groups on admission were significantly lower than those of the control group. The apoptotic functions were lower in ALL patients with malnutrition than those in ALL patients without malnutrition, but this was not statistically significant. The repeated apoptotic functions of both ALL groups were increased to similar values with the control group. This increase was found to be statistically significant. Conclusions: The apoptotic functions in ALL patients were not found to be affected by malnutrition. However, after dietary intervention, increased apoptotic functions in both ALL patient groups deserve mentioning. Dietary intervention should always be recommended as malnutrition or cachexia leads to multiple complications. Enhanced apoptosis might originate also from remission state of cancer.
- PublicationMetadata onlyManagement of diffuse pontine gliomas in children: recent developments(2013-10-01) ÇAKIR, FATMA BETÜL; Kebudi, Rejin; ÇAKIR, FATMA BETÜLThe prognosis for children with diffuse intrinsic pontine gliomas (DIPGs) is dismal. Although DIPGs constitute only 10-15 % of all pediatric brain tumors, they are the main cause of death in this group with a median survival of less than 12 months. Standard therapy involves radiotherapy, which produces transient neurologic improvement. Despite several clinical trials having been conducted, including trials on targeted agents to assess their efficacy, there is no clear improvement in prognosis. However, knowledge of DIPG biology is increasing, mainly as a result of research using biopsy and autopsy samples. In this review, we discuss recent studies in which systemic therapy was administered prior to, concomitantly with, or after radiotherapy. The discussion also includes novel therapeutic options in DIPG. Continuing multimodal and multitargeted therapies might lead to an improvement in the dismal prognosis of the disease.
- PublicationOpen AccessRelationships Between Bronchoscopy, Microbiology, and Radiology in Noncystic Fibrosis Bronchiectasis(2021-05-01T00:00:00Z) NURSOY, MUSTAFA ATİLLA; KILINÇ SAKALLI, Ayşe Ayzıt; ABDİLLAHİ, FATOUMA KHALİF; USTABAŞ KAHRAMAN, Feyza; Al Shadfan, Lina Muhammed; SÜMBÜL, BİLGE; Bilgin, Sabriye Sennur; ÇAKIR, FATMA BETÜL; DAŞKAYA, HAYRETTİN; ÇAKIR, Erkan; NURSOY, MUSTAFA ATİLLA; ABDİLLAHİ, FATOUMA KHALİF; USTABAŞ KAHRAMAN, FEYZA; SÜMBÜL, BİLGE; ÇAKIR, FATMA BETÜL; DAŞKAYA, HAYRETTİN; ÇAKIR, ERKANBackground: Published data on the correlations of bronchoscopy findings with microbiological, radiological, and pulmonary function test results in children with noncystic fibrosis (CF) bronchiectasis (BE) are unavailable. The aims of this study were to evaluate relationships between Bronchoscopic appearance and secretion scoring, microbiological growth, radiological severity level, and pulmonary function tests in patients with non-CF BE. Methods: Children with non-CF BE were identified and collected over a 6-year period. Their medical charts and radiologic and bronchoscopic notes were retrospectively reviewed. Results: The study population consisted of 54 female and 49 male patients with a mean age of 11.7 ± 3.4 years. In the classification according to the bronchoscopic secretion score, Grade I was found in 2, Grade II in 4, Grade III in 9, Grade IV in 17, Grade V in 25, and Grade VI in 46 patients. When evaluated according to the Bhalla scoring system, 45 patients had mild BE, 37 had moderate BE, and 21 had severe BE. Microbial growth was detected in bronchoalveolar lavage fluid from 50 of the patients. Forced expiratory volume in 1 s (FEV1) and functional vital capacity decreased with increasing bronchoscopic secretion grade (P = 0.048 and P = 0.04), respectively. The degree of radiological severity increased in parallel with the bronchoscopic secretion score (P = 0.007). However, no relationship was detected between microbiological growth rate and radiological findings (P = 0.403). Conclusions: This study showed that bronchoscopic evaluation and especially scoring of secretions correlate with severe clinical condition, decrease in pulmonary function test, worsening in radiology scores, and increase in microbiological bacterial load in patients. Flexible endoscopic bronchoscopy should be kept in mind in the initial evaluation of non-CF BE patients.