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HEKİMOĞLU, EMİNE RÜMEYSA

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EMİNE RÜMEYSA
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HEKİMOĞLU
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    Fetal Cell Microchimerism; Normal and Immunocompromised Gestations in Mice
    (2019-01-01) Beksac, M. Sinan; Fadiloglu, Erdem; Cakar, Ayse Nur; Gurbuz, Rumeysa Hekimoglu; Atilla, Pergin; Onbasilar, Ilyas; Beksac, Kemal; Katlan, Doruk Cevdi; Mumusoglu, Sezcan; Calis, Pinar; Beksac, Meral; HEKİMOĞLU, EMİNE RÜMEYSA
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    Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus
    (2019-01-01) Gurbuz, Rumeysa Hekimoglu; ATİLLA, PERGİN; Orgul, Gokcen; TANAÇAN, ATAKAN; Dolgun, Anil; Cakar, Ayse Nur; BEKSAÇ, MEHMET SİNAN; HEKİMOĞLU, EMİNE RÜMEYSA
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    Histopathological Analysis of Internal Limiting Membrane Surgically Peeled From Eyes with Epiretinal Membrane
    (2016-02-01) Beyazyildiz, Özlem; Tirhiş, Mehmet Hakan; Hekimoğlu, Emine Rümeysa; Beyazyildiz, Emrullah; Kaymaz, Figen; Yilmazbaş, Pelin; Öztürk, Faruk; HEKİMOĞLU, EMİNE RÜMEYSA
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    Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles
    (2018-09-01) Yucel Cicek, Ozge Senem; Hekimoglu, Emine Rümeysa; Turgal, Mert; ATİLLA, PERGİN; Cakar, Ayse Nur; USUBÜTÜN, ALP; BEKSAÇ, MEHMET SİNAN; HEKİMOĞLU, EMİNE RÜMEYSA
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    Prefabricated Osteocutaneous Neural Island Flap Model
    (2011-11-01) Sonmez, Erhan; Ocal, Engin; Konas, Ersoy; Hekimoglu, Rumeysa; KORKUSUZ, PETEK; Dadaci, Mehmet; Safak, Tunc; HEKİMOĞLU, EMİNE RÜMEYSA
    Neural-based flaps are an interesting clinical choice particularly in difficult cases that may not be reconstructed with known techniques. Their popularity is gradually increasing because these flaps offer the advantage of preservation of major extremity arteries and avoidance of microsurgical techniques. Our aim was to explore the feasibility of prefabrication of an osteocutaneous neural island flap model in this study. A peripheral nerve of the rat was implanted into the subcutaneous tissue of a skin flap that was connected to a segment of bone by a soft-tissue bridge, to prefabricate an osteocutaneous flap that was supplied only by the intrinsic vasculature of that nerve after a preliminary delay period. At the end of this study, based on direct observation, microangiographic findings, and additionally, a detailed histologic analysis consisting of both qualitative and quantitative assessments, we have proved that it was possible to prefabricate an osteocutaneous composite flap based on the vascularity of a peripheral nerve after a 2-step delay period. We believe that the clinical application of this new flap will gradually develop based on further experimental studies.
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    Trimetazidine has protective effects on spermatogenesis in a streptozotocin-induced diabetic rat model
    (2017-12-01) Ozcan, M.F.; Hekimoglu, Emine Rümeysa; Ener, K.; Namuslu, M.; Altintas, R.; Celik, H.T.; Akbulut, Z.; Altinova, S.; HEKİMOĞLU, EMİNE RÜMEYSA
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    Local Ocular Surface Alterations in Children with Hashimoto-s Thyroiditis
    (2019-08-17) Kiziltoprak, Hasan; Koc, Mustafa; Tekin, Kemal; Hekimoglu, Rumeysa; Inanc, Merve; Yilmaz, Aslihan Arasli; Elmaogullari, Selin; Aycan, Zehra; HEKİMOĞLU, EMİNE RÜMEYSA
    Purpose: To evaluate the ocular surface characteristics based on Schirmer-s test, tear break-up time (TBUT), and conjunctival impression cytology (CIC) in children with Hashimoto-s thyroiditis (HT). Methods: This study included 51 children with HT and 53 control subjects. The ocular surface characteristics of participants were assessed via Schirmer-s test, TBUT, and CIC. Conjunctival samples were examined cytologically according to the Nelson grading system. Results: Schirmer-s and TBUT results were significantly lower in HT group (p < .05). All samples in both the study and control groups were evaluated as grade 0 according to the Nelson classification (p = .841), however, goblet cell density (GCD) was significantly lower in HT group (p = .001). Schirmer test results were significantly associated with the duration of HT (p = .025, r = -0.311). Conclusion: Hashimoto-s thyroiditis without any ocular complaints may cause ocular surface changes with TBUT and Schirmer-s. Although CIC analysis showed similar grading results, GCD was significantly decreased in HT group.
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    Evaluation of umbilical cord immune cells in pregnancies with autoimmune disorders and/or methylenetetrahydrofolate reductase polymorphisms.
    (2022-03-28T00:00:00Z) Sekkin Eser, Miray; Ulutas Ugur, Yesim; Tanacan, Atakan; Gurbuz Hekimoglu, Rumeysa; Cakar, Ayse Nur; Beksac, Mehmet Sinan; HEKİMOĞLU, EMİNE RÜMEYSA
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    Evaluation of ciliary functions and ciliary beat frequency via cell culture method in patients with primary ciliary dyskinesia
    (2022-07-01T00:00:00Z) EMİRALİOĞLU ORDUKAYA, NAGEHAN; HEKİMOĞLU, EMİNE RÜMEYSA; Kaya, Bengisu; Bilgic, Elif; ATİLLA, PERGİN; Gunaydin, Onder; Tugcu, Gokcen Dilsa; Polat, Sanem Eryilmaz; Hizal, Mina Gharibzadeh; Yalcin, Ebru; DOĞRU ERSÖZ, DENİZ; Kiper, Nural; Ozcelik, Ugur; HEKİMOĞLU, EMİNE RÜMEYSA
    Background: Cell culture increases both diagnostic specificity and sensitivity of primary ciliary dyskinesia (PCD) and the most important reason to use cell culture for definitive diagnosis in PCD is to exclude secondary ciliary defects. Here we aimed to evaluate the cilia functions and cilia ultrastructural abnormalities after ciliogenesis of cell culture in patients with definitive diagnosis of PCD. We also aimed to compare high speed videomicroscopy (HSVM) results of patients before and after ciliogenesis and to compare them with electron microscopy, genetic and immunofluorescence results in patients with positive diagnosis of PCD. Methods: This study was conducted as a cross-sectional study in patients with PCD. HSVM, transmission electron microscopy (TEM) and immunofluorescence staining results of the nasal biopsy samples taken from patients with the definitive diagnosis of PCD were evaluated and HSVM findings before and after cell culture were described. Results: Ciliogenesis and regrowth in the cell culture occurred in the nasal biopsy sample of eight patients with PCD. The mean age of the patients was 15.5±4.2 years (8.5-18 years). Mean beat frequency was found to be 7.54±1.01 hz (6.53-9.45 hz) before cell culture, and 7.36±0.86 hz (6.02-7.99 hz) after cell culture in the nasal biopsy of patients. There was no significant difference in the beat frequency of PCD patients before and after cell culture. Ciliary function analysis showed the similar beating pattern before and after cell culture in patients with PCD. Conclusions: This study showed us that there was no difference between cilia beat frequency and beat pattern before and after cell culture in patients with definitive diagnosis of PCD and repeated HSVM would be a useful diagnostic approach in patients who have no possibility to reach other diagnostic methods.