Person: ŞENGÜL, YILDIZHAN
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Investigation of alexithymia and levels of anxiety and depression among patients with restless legs syndrome.
Purpose: The purpose of this study was to examine alexithymia among restless legs syndrome (RLS) patients, compare with healthy controls, and argue the clinical inferences of this relationship. We searched for anxiety and depression and their clinical outcomes among patients and searched whether the results are similar to previous studies. Patients and methods: Eighty-seven RLS patients and 88 age, gender, and educationally matched healthy controls were assessed in Bezmialem Foundation University Hospital. RLS patients and healthy controls were assessed with the Sociodemographic Data Form constructed for the present study, 20-item Toronto Alexithymia Scale (TAS-20), Beck Depression Inventory (BDI), and Beck Anxiety Scale (BAS). The patient group was also assessed with the International Restless Legs Syndrome Study Group (IRLSSG) RLS Severity Scale. Results: RLS patients were found to have greater TAS-20, BDI, and BAS scores compared with the control group (P < 0.05). RLS severity score was positively correlated with the scores of anxiety and depression scales. However, no significant relationship was found between scores of IRLSSG RLS scale and TAS-20 total and subscale scores. Conclusion: RLS patients were found to be more alexithymic than healthy controls, whereas no significant relationship was found between RLS severity and levels of alexithymia. Still, alexithymia might be a predictor for early diagnosis and may be considered in the treatment and follow-up of RLS. RLS patients have higher depression and anxiety scores than healthy individuals. Thus, depression and anxiety should be taken into consideration throughout the RLS treatment.
EVALUATION OF NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO IN ESSENTIAL TREMOR IS THERE SYSTEMIC INFLAMMATION IN ESSENTIAL TREMOR?
Introduction - Although essential tremor (ET) is the most common cause of tremor, the pathology and underlying mechanisms have not fully understood yet. In addition to kinetic tremor, patients may present several types of tremor, gait ataxia, hearing deficits and eye movement abnormalities. Non-motor symptoms and signs have also added to definition of ET. There is significant evidence indicating the neurodegenerative nature of the disease. New studies indicate that inflammation may have a place in the etiology. The neutrophil-to lymphocyte ratio (NLR) and the platelet-to lymphocyte ratio (PLR) have recently begun to be used as a marker of systemic inflammation. Our study aims at finding a clue for systemic inflammation in ET.
Investigation and Clinical Importance of Obsessive and Compulsive Signs Among Patients with Restless Legs Syndrome
Objective: The purpose of this study was to examine obsessive and compulsive signs among patients with Restless Legs syndrome (RLS), to compare the results with healthy controls and to investigate clinic importance of those signs. Methods: Thirty nine patients with RLS and 40 age-, sex- and education- matched healthy controls were assessed in Bezmialem Foundation University Medical Faculty Hospital Neurology and Psychiatry Clinics Hospital. Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV axis-1 disorders severe combined immune deficiency-1, socio-demographic data form and Maudsley obsessive compulsive inventory (MOCI) were applied to both patients and controls. Patient group seas also classified according to the International RLS study group RLS severity scale. Results: Patient group had higher MOCI total scores and doubting and rumination subscale scores than the control group and the difference was statistically significant (p<0.05). No statistically significant relationship was found between RLS severity score and MOCI total and subscale scores. Conclusion: Patients with RLS were generally found to have more obsessive and compulsive signs than healthy controls. In view of the fact that RLS is often a late-diagnosed syndrome, searching for concomitant RLS among young people who have obsessive and compulsive signs may be helpful for early diagnosis of RLS.