Person: ŞENGÜL, YILDIZHAN
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Publication Metadata only Essential Tremor and Alexithymia(2018-10-01) ŞENGÜL, YILDIZHAN; ŞENGÜL, HAKAN SERDAR; GÖKÇAL, ELİF; ÜSTÜN, İSMET; ÖZTÜRK, AHMET; YILMAZ, ONUR; YILDIZ, GÜLSEN; ŞENGÜL, YILDIZHAN; GÖKÇAL, ELİF; ÜSTÜN, İSMET; ÖZTÜRK, AHMET; YILMAZ, ONURPublication Metadata only Genç Multipl Skleroz ve Esansiyel Tremor Hastalarında Kognitif Bozulma: Bir Karşılaştırmalı Çalışma/Cognitive Impairment in Young Multiple Sclerosis and Essential Tremor Patients: a comparative study(2018-04-01) Şengül, Hakan Serdar; ŞENGÜL, YILDIZHAN; Yücel, Selma; Forta, Hulki; ŞENGÜL, YILDIZHANPublication Metadata only PSYCHOFORM AND SOMATOFORM DISSOCIATIVE EXPERIENCES IN MIGRAINE: RELATIONSHIP WITH PAIN PERCEPTION AND MIGRAINE RELATED DISABILITY(2018-11-01T00:00:00Z) ŞENGÜL, YILDIZHAN; Sengul, Hakan Serdar; Tunc, Abdulkadir; ŞENGÜL, YILDIZHANObjective - Migraine is a common and often debilitating disorder. Although the existence of a link between migraine and certain psychological features has long been known, data on dissociative experiences in migraine patients is insufficient. The aim of this study was to evaluate the presence of psychoform and somatoform dissociative experiences among migraine patients without aura and to examine their relationship with pain perception and disability.Publication Metadata only A comparison between rate of nonmotor symptom development in essential tremor and Parkinson-s disease.(2015-09-01T00:00:00Z) BAKIM, BAHADIR; Sengul, YILDIZHAN; SENGUL, HS; Sural, MK; FORTA, H; ŞENGÜL, YILDIZHANPublication Metadata only Sleep disturbances and excessive daytime sleepiness in migraine: A comparison between comorbidities and disability(2015-01-01T00:00:00Z) Sengul, YILDIZHAN; SENGUL, Hakan S.; Bakim, Bahadir; YUCEKAYA, Sevda K.; YUCEL, Selma; AKGUN, Mucella; ŞENGÜL, YILDIZHANMany studies have investigated the association between headache and sleep disorders, but few have focused on migraine. The goal of this study was to evaluate sleep disturbance and excessive daytime sleepiness (EDS) in relation to migraine disability. 120 migraine patients who were diagnosed according to The International Classification of Headache Disorders-II and 45 healthy controls were recruited for the study. All participants completed the Pittsburg Sleep Quality Index (PSQI), the Epworth Sleepiness Scale, Beck Depression Inventory and Beck Anxiety Scale. Migraineurs completed Migraine Disability Assessment Scale (MIDAS) and Visual Analog Scale. The prevalence of poor sleep was 83.3% in the patients and 22.2% in the controls. All PSQI subgroup scores were higher for the patients than the controls except Hours asleep. EDS was more prominent in the patient group (19.2% vs 2.2%). In conclusion, sleep disturbance, EDS, anxiety, and depressive symptoms were detected more commonly in migraine patients and were correlated with the migraine-related disability. The results of multivariate regression analysis indicated that EDS and sleep disturbance were the most effective factors on disability.Publication Metadata only Cognitive Impairment in Young Multiple Sclerosis and Essential Tremor Patients: A Comparative Study(2016-09-01T00:00:00Z) Sengul, Hakan Serdar; ŞENGÜL, YILDIZHAN; Yucel, Selma; Forta, Hulki; ŞENGÜL, YILDIZHANObjective: In multiple sclerosis (MS); memory, attention, information processing speed, and executive function deficits associated with cortical demyelination and atrophy can be seen in the early phases. In essential tremor (ET) cognitive impairment associated with cerebral-thalamocortical pathway dysfunction, which is characterized by visuospatial functions, verbal memory, and executive functions were seen. We aimed to evaluate cognitive impairment in patients with MS and ET, and to compare the features of impairment.Publication Metadata only Sleep disturbances in essential tremor: an investigation of associated brain microstructural changes using diffusion tensor imaging(2021-05-01T00:00:00Z) Sengul, Yildizhan; Temur, Hafize Otcu; Sengul, Hakan S.; Ustun, Ismet; Radler, Keith; ALKAN, ALPAY; Louis, Elan D.; ŞENGÜL, YILDIZHAN; ÜSTÜN, İSMET; ALKAN, ALPAYEssential tremor (ET) is a complex, neurodegenerative disorder that includes motor and non-motor symptoms. There is growing interest in its non-motor features, including sleep disturbances (SD). There are no studies evaluating the brain structural correlates of SD in ET. We aimed to identify brain microstructural changes related to SD in ET. SD was evaluated using the Pittsburg sleep quality index (PSQI). Diffusion tensor imaging (DTI), with reported measures being fractional anisotropy (FA) and apparent diffusion coefficient (ADC), was used to evaluate microstructural brain changes. DTI data were compared in ET patients with vs. without SD. The mean age of 40 ET patients was 49.20 +/- 21.06 years. The mean PSQI score was 6.13 +/- 3.99, and 18 (45.0%) patients had SD. The mean PSQI score of patients with vs. without SD was 9.78 +/- 2.98 vs. 3.14 +/- 1.28 (p < 0.001). Patients with vs. without SD differed significantly with respect to several DTI findings: right (R) superior cerebellar peduncle ADC (p = 0.04), left (L) dorsolateral prefrontal cortex FA (p < 0.01), L frontooccipital fasciculus FA (p = 0.02), R posterior corona radiata (RPCR) FA (p = 0.01), L posterior corona radiata FA (p = 0.04), R posterior thalamic radiation (RPTR) FA (p = 0.02), and fornix FA (p = 0.03) Significant correlations between PSQI scores and RPCR FA (r = - 0.50, p = 0.02) and RPTR FA (r = - 0.67, p = 0.001) were also observed. Our findings suggest that certain brain changes may be associated with the clinical expression of SD in ET. These changes are discussed in terms of their possible neuroanatomical and physiological significance.Publication Metadata only Esansiyel Tremor Hastalarında Yüz Duygu Tanıma(2018-12-01) Şengül, YILDIZHAN; TUNÇ, ABDULKADİR; YILMAZ, ONUR; ÖZTÜRK, AHMET; ŞENGÜL, YILDIZHAN; TUNÇ, ABDULKADIR; YILMAZ, ONUR; ÖZTÜRK, AHMETPublication Metadata only Comparison of optic coherence tomography results in patients with diagnosed epilepsy: Findings in favor of neurodegeneration(2019-03-01T00:00:00Z) TAK, ALİ ZEYNAL ABİDİN; ŞENGÜL, YILDIZHAN; Ekmekci, Burcu; KARADAĞ, AYŞE SEVGİ; ŞENGÜL, YILDIZHANBackground: Epilepsy is a chronic neurological disease characterized with recurrent seizures. Progressive neuronal degeneration is a common consequence of long-term and/or recurrent seizure activity in epilepsy. Optical coherence tomography (OCT) is a new medical imaging technique that displays biological tissue layers as high-resolution tomographic sections. The aim of our study was to evaluate OCT findings in patients with epilepsy and to compare OCT findings in terms of disease duration, presence of status, seizure frequency, and drug use.Publication Metadata only Evaluation of thickness of retinal nerve fiber layer, ganglion cell layer, and choroidal thickness in essential tremor: can eyes be a clue for neurodegeneration?(2018-06-01) Tak, Ali Zeynel Abidin; Sengul, YILDIZHAN; Karadag, Ayse Sevgi; ŞENGÜL, YILDIZHANThe pathology of essential tremor (ET) and underlying mechanisms of the disease are still unclear, but an increasing amount of research has been conducted on the subject. Discussions are ongoing about ET-s definition as a neurodegenerative disease. Optic coherence tomography (OCT) provides a window to the brain where direct visualization of central nervous system (CNS) changes may be possible, and it can help us to develop a new point of view on ET. The goal of this study was to examine OCT parameters in ET. 40 ET patients and 40 healthy controls, i.e., a total of 160 eyes were evaluated. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid thinning were analyzed using spectral domain OCT. The mean age was 25.77 +/- 8.98 in the ET group and 27.25 +/- 8.22 in the control group. We found a decreased global RNFL thickness for both eyes in ET patients. All GCL and IPL thickness parameters were lower in the patients with ET (P < 0.001, P 0.03). Choroid was significantly thicker in ET patients than the controls (P < 0.001). Our study-s results suggest that the usefulness of OCT in detecting neurodegeneration in ET. RNFL, GCL, IPL measurements are highly reproduced findings of neurodegeneration. Increased choroid volume may indicate neuroinflammation. Eyes in ET may shed light on nature of the disease, and may be used as a diagnostic tool.