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YARDIMCI, ERKAN

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ERKAN
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YARDIMCI
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Now showing 1 - 9 of 9
  • PublicationOpen Access
    Safe thyroidectomy with intraoperative methylene blue spraying.
    (2012-11-13) SARI, S; Aysan, E; MUSLUMANOGLU, M; ERSOY, YELİZ EMİNE; BEKTASOGLU, HÜSEYİN KAZIM; YARDıMCı, ERKAN; AYŞAN, MUSTAFA ERHAN; ERSOY, YELIZ EMINE; BEKTAŞOĞLU, HÜSEYİN KAZIM; YARDIMCI, ERKAN
    Background: We aimed to minimalize operative complications by spraying of methylene blue stain on thyroid glands and the perithyroidal area. Material and methods: The intra-operative methylene blue spraying technique was used prospectively on a total of 56 patients who had undergone primary (not recurrent) thyroid surgery for a variety of thyroid diseases. Bilateral total thyroidectomy was performed in all cases. After superior but before inferior pole ligation, 0.5ml of methylene blue was sprayed over the thyroid lobe and perilober area. Tissues, especially parathyroides, the recurrent laryngeal nerve, and the inferior thyroid artery, were identified and evaluated. Results: Recurrent laryngeal nerve and arteries were not stained and thus they remained white in all cases while all other tissues were stained blue. Within three minutes parathyroid glands washed out the blue stain and the original yellow color was regained. Thyroid tissue wash-out time was not less than 15 minutes; perithyroideal muscles, tendinous and lipoid structures took no less than 25 minutes. Conclusion: The safety of intravascular methylene blue guidance on thyroid surgery is known. This research demonstrates the effectiveness of the spraying technique, a new technique which ensures not only identification of parathyroid glands within three minutes, but also identification of recurrent laryngeal nerves and inferior thyroid arteries.
  • PublicationOpen Access
    Comparison of Weight Loss, Ghrelin, and Leptin Hormones After Ligation of Left Gastric Artery and Sleeve Gastrectomy in a Rat Model.
    (2017-03-24) YARDIMCI, ERKAN; BOZKURT, SÜLEYMAN; CENGIZ, MB; Malya, FATMA ÜMİT; YARDIMCI, ERKAN; BOZKURT, SÜLEYMAN; MALYA, FATMA ÜMİT
    BACKGROUND Ligation of the left gastric artery (LLGA), which supplies the fundus of the stomach, may reduce the appetite hormone ghrelin, resulting in weight control. The aim of this study was to compare LLGA and sleeve gastrectomy (SG) in terms of postoperative outcomes in a rat model. MATERIAL AND METHODS Fifteen male Wistar albino rats, weighing >350 grams (range 350-525 grams), were enrolled in LLGA (N=5), SG (N=5), and control (N=5) groups. Blood samples were drawn preoperatively and also during the first and fourth week postoperatively to assay ghrelin and leptin hormone levels. Body weight was measured in each group. RESULTS The maximum reduction in ghrelin level (41.5%) was found in the LLGA group. Considerable% total weight loss (TWL) (mean 24.1%) was observed in the SG group, and slight%TWL was noted in the control and LLGA groups (means of 0.1% and 2.1%, respectively). There was no significant difference in mean percent weight change between the LLGA and the SG groups (p=0.08). Blood sample analysis revealed no statistically significant changes in ghrelin or leptin levels between the groups (p=0.9 and p=0.3, respectively). CONCLUSIONS We present evidence that LLGA causes the same reduction in ghrelin hormone levels as SG at 4 weeks after surgery in a rat model. However, LLGA did not cause the same%TWL as SG. The mechanism of weight loss in SG is most likely due to restriction and to the effects of the procedure, rather than due to neurohormonal changes.
  • PublicationOpen Access
    Metachronous metastatic paraganglioma in jejunum as a rare entity: A case report
    (2015-03-01) Bektasoglu, HÜSEYİN KAZIM; CIPE, Gokhan; YARDIMCI, ERKAN; Arici, DİLEK SEMA; HASBAHCECI, Mustafa; KARATEPE, Oguzhan; MUSLUMANOGLU, Mahmut; BEKTAŞOĞLU, HÜSEYİN KAZIM; YARDIMCI, ERKAN; ARICI, DILEK SEMA
    Pheochromocytomas and paragangliomas are neuroendocrine tumors that arise from chromaffin cells of adrenal medulla and extra-adrenal paraganglia, respectively. The recurrence of these neuroendocrine tumors as a jejunal mass causing obstruction in the small intestine is an exceptional entity. The present study reports the case of a 70-year-old male who presented to the Emergency Department of Bezmialem Vakif University Hospital with abdominal pain and vomiting. The patient possessed a history of left nephrectomy due to malignant pheochromocytoma that had invaded into the left kidney eight months prior to presentation. Bowel obstruction was diagnosed and the patient underwent a laparoscopic procedure. Partial resection of the jejunum was performed and immunohistochemical studies revealed the lesion to be malignant paraganglioma. The majority of paragangliomas are chemo- and radioresistant. Surgical excision remains the primary treatment. Metachronous paraganglioma arising from the small intestine is an extremely rare entity and may be a relevant consideration in patients presenting with bowel obstruction.
  • PublicationOpen Access
    Nonclosure of the Peritoneum during Appendectomy May Cause Less Postoperative Pain: A Randomized, Double-Blind Study
    (2019-01-01) BEKTAŞOĞLU, HÜSEYİN KAZIM; Hasbahceci, Mustafa; YIĞMAN, SAMET; YARDIMCI, ERKAN; KUNDUZ, ENVER; MALYA, FATMA ÜMİT; BEKTAŞOĞLU, HÜSEYİN KAZIM; YIĞMAN, SAMET; YARDIMCI, ERKAN; KUNDUZ, ENVER; MALYA, FATMA ÜMİT
    Objective: We aim to evaluate the effect of peritoneal closure on postoperative pain and life quality associated with open appendectomy operations. Methods: This is a single-center, prospective, randomized, and double-blinded study. Here, 18-65-year-old patients who underwent open appendectomy for acute appendicitis were included. Demographic data of the patients, operation time, length of hospital stay, pain scores using a 10 cm visual analogue scale (VAS) on the first postoperative day, quality of life assessment using the EuroQol-5D-5L questionnaire on postoperative 10th day, deep wound dehiscence, bowel obstruction, and mortality data were recorded. Results: In total, 112 patients were included in the study. The demographic data showed no significant difference between the groups. The median VAS score was lower in the group with open peritoneum, but this difference was not statistically significant (3 vs. 4, p=0.134). The duration of surgery was significantly shorter in the peritoneal nonclosure group (31.0 ± 15.1 vs. 38.5 ± 17.5 minutes, p=0.016). Overall complication rates and life quality test (EuroQol-5D-5L) results were similar between groups. Conclusion: Nonclosure of the peritoneum seems to shorten the duration of surgery without increasing complications during open appendectomy. Postoperative pain and life quality measures were not affected by nonclosure of the peritoneum. This trial is registered with NCT02803463.
  • PublicationOpen Access
    Intraoperative palpation of sentinel lymph nodes can accurately predict axilla in early breast cancer
    (2019-01-01) Ozkurt, Enver; Yardimci, ERKAN; Tukenmez, Mustafa; Ersoy, YELİZ EMİNE; Yilmaz, Ravza; Cabioglu, Neslihan; Karanlik, Hasan; Kulle, Cemil Burak; Malya, FATMA ÜMİT; Onder, Semen; Gucin, ZÜHAL; Igci, Abdullah; Ozmen, Vahit; Dinccag, Ahmet Sait; Muslumanoglu, Mahmut; YARDIMCI, ERKAN; ERSOY, YELIZ EMINE; MALYA, FATMA ÜMİT; GÜCİN, ZÜHAL
    Recent randomized trials have shown that completion axillary lymph node dissection (ALND) is not required in all patients with a positive sentinel lymph node (SLN) who will receive radiation therapy. Although routine intraoperative pathologic assessment (IPA) becomes unnecessary and less indicated by breast surgeons in the United States and some European countries, it is still widely used all around the world. In this prospective study, the feasibility of intraoperative nodal palpation (INP) as opposed to IPA of the SLN has been analyzed. Between March 2014 and June 2015, 305 patients with clinical T1-2/N0 breast cancer from two different breast clinics (cohort A; [n = 225] and cohort B; [n = 80]) who underwent any breast surgery with sentinel lymph node biopsy (SLNB) were included in this study. Surgeons evaluated the SLNs by manual palpation before sending for IPA, and findings compared with the final pathology. The positive predictive values (PPV) of INP and IPA were 81.8% and 97.9%, respectively, whereas the negative predictive values (NPV) of INP and IPA were 83% and 92.4%. The accuracies of INP and IPA were 82.6% and 94.1%, respectively. If patients with SLNB including micrometastasis were also considered in the final pathologic assessment (FPA) (-) group that would not require a further axillary dissection, the revised NPV of INP and FPA were found to be 92.6% and 98.1%, respectively. The revised accuracy of INP also found to be increase to 86.9%. Our study, which is the only prospective one about palpation of dissected SLNs in the literature, suggests that INP can help to identify patients who do not need ALND, which encourages omitting IPA in cT1-2 N0 breast cancer.
  • PublicationOpen Access
    Intersphincteric resection and coloanal anastomosis in treatment of distal rectal cancer.
    (2012-01-01) CIPE, G; MUSLUMANOGLU, M; YARDıMCı, ERKAN; MEMMI, NAİM; Aysan, E; YARDIMCI, ERKAN; MEMMİ, NAİM; AYŞAN, MUSTAFA ERHAN
    In the treatment of distal rectal cancer, abdominoperineal resection is traditionally performed. However, the recognition of shorter safe distal resection line, intersphincteric resection technique has given a chance of sphincter-saving surgery for patients with distal rectal cancer during last two decades and still is being performed as an alternative choice of abdominoperineal resection. The first aim of this study is to assess the morbidity, mortality, oncological, and functional outcomes of intersphincteric resection. The second aim is to compare outcomes of patients who underwent intersphincteric resection with the outcomes of patients who underwent abdominoperineal resection.
  • PublicationOpen Access
    Impact of anxiety on sedative medication dosage in patients undergoing esophagogastroduodenoscopy.
    (2018-06-01T00:00:00Z) Gürbulak, B; Üçüncü, MZ; Yardımcı, ERKAN; Kırlı, E; Tüzüner, F; YARDIMCI, ERKAN
  • PublicationOpen Access
    Ileocecal Intussusception due to a Lipoma in an Adult.
    (2012-01-01) Bilgin, MEHMET; Toprak, HÜSEYİN; AHMAD, ISSAM CHEIKH; YARDIMCI, ERKAN; KOCAKOÇ, ERCAN; BİLGİN, MEHMET; TOPRAK, HÜSEYİN; YARDIMCI, ERKAN
    While intestinal tumors are rare, small intestinal lipomas are even more uncommon benign neoplasms. They are usually asymptomatic, but lipomas larger than 2 cm may become symptomatic due to obstruction, bleeding, or intussusception. In this paper, US and CT findings of a lipoma located in the terminal ileum and causing ileocecal intussusception were discussed. We report a case of small bowel lipoma that became symptomatic due to intermittent obstruction episodes and ileocecal intussuception. If the diagnosis of intestinal lipoma had been made absolutely as in our case, they should be removed surgically in elective conditions.
  • PublicationOpen Access
    Mechanism of body weight reducing effect of oral boric Acid intake.
    (2013-01-01) Aysan, E; SAHIN, F; TELCI, D; ERDEM, M; MUSLUMANOGLU, M; YARDıMCı, ERKAN; BEKTASOGLU, HÜSEYİN KAZIM; AYŞAN, MUSTAFA ERHAN; YARDIMCI, ERKAN; BEKTAŞOĞLU, HÜSEYİN KAZIM
    Objective. The effect of oral boric acid intake on reducing body weight has been previously demonstrated although the mechanism has been unclear. This research study reveals the mechanism. Subjects. Twelve mice were used, in groups of six each in the control and study groups. For five days, control group mice drank standard tap water while during the same time period the study group mice drank tap water which contains 0.28 mg/250 mL boric acid. After a 5-day period, gene expression levels for uncoupling proteins (UCPs) in the white adipose tissue (WAT), brown adipose tissue (BAT), and skeletal muscle tissue (SMT) and total body weight changes were analyzed. Results. Real time PCR analysis revealed no significant change in UCP3 expressions, but UCP2 in WAT (𝑃: 0.0317), BAT (𝑃: 0.014), and SMT (𝑃: 0.0159) and UCP1 in BAT (𝑃: 0.026) were overexpressed in the boric acid group. In addition, mice in the boric acid group lost body weight (mean 28.1%) while mice in the control group experienced no weight loss but a slight weight gain (mean 0.09%, 𝑃 < 0.001). Conclusion. Oral boric acid intake causes overexpression of thermogenic proteins in the adipose and skeletal muscle tissues. Increasing thermogenesis through UCP protein pathway results in the accelerated lipolysis and body weight loss.