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AKKAN, AHMET GÖKHAN

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AHMET GÖKHAN
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AKKAN
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Now showing 1 - 4 of 4
  • PublicationMetadata only
    Cardiac Troponin-I (cTnI) a Biomarker of Cardiac Injuries Induced by Doxorubicin Alone and in Combination with Ciprofloxacin, Following Acute and Chronic Dose Protocol in Sprague Dawley Rats
    (2014-07-01T00:00:00Z) Shahzadi, Andleeb; Sonmez, Ikbal; Allahverdiyev, Oruc; Onal, Burak; Kandaz, Cemre; Ozyazgan, Sibel Ozmen; Akkan, Ahmet Gökhan; Yazici, Zeliha; AKKAN, AHMET GÖKHAN
    The present study investigates the release of cardiac troponin-I (cTnI) as a biomarker of cardiac injuries induced by doxorubicin (Doxo) alone and along with ciprofloxacin (Cipro), following acute and chronic dose protocol in Sprague Dawley rats. In chronic protocol, rats were given multiple intra-peritoneal (i.p) injections of Doxo (1 or 2.5 mg kg(-1)) alone or in combination with Cipro (20 mg kg(-1) daily) and a placebo control. Whereas in acute protocol, rats were subjected to receive single i.p. injection of Doxo (6 or 15 mg kg(-1)) alone or along with Cipro (20 mg kg(-1)) and placebo treatment with saline (control). The plasma levels of cTnI were measured by using Enzyme-linked Immuno Sorbent Assay (ELISA) technique. All the treated groups, following acute or chronic dose protocol showed significant increase in cTnI plasma level from 137-248% in comparison to control (p<0.0001). The cTnI plasma levels increased in dose dependent manner after following acute and chronic dose protocol. The difference between two doses following chronic (1 mg kg(-1) vs. 2.5 mg kg(-1)) and acute (6 vs. 15 mg kg(-1)) administration was 34.6 and 31.5%, respectively. Results of this investigation suggest that Doxo alone and in combination with Cipro from both the chronic and acute groups showed cardio-toxicity (release of cTnI). To our knowledge this is the first description towards Doxo-Cipro is induced cardiotoxicity and could be a bridge between preclinical and clinical practice for physicians in making an expert opinion dealing with above mentioned group.
  • PublicationMetadata only
    The Anti-Inflammatory Effects of Anacardic Acid on a TNF-alpha Induced Human Saphenous Vein Endothelial Cell Culture Model
    (2020-01-01T00:00:00Z) DURSUN, Erdinç; Onal, Burak; Ozen, Deniz; Demir, Bulent; Ak, Duygu Gezen; Demir, Caner; Akkan, Ahmet Gökhan; Ozyazgan, Sibel; AKKAN, AHMET GÖKHAN
    Background and Objective: Coronary bypass operations are commonly performed for the treatment of ischemic heart diseases. Coronary artery bypass surgery with autologous human saphenous vein maintains its importance as a commonly used therapy for advanced atherosclerosis. Vascular inflammation-related intimal hyperplasia and atherosclerotic progress have major roles in the pathogenesis of saphenous vein graft disease.
  • PublicationMetadata only
    Does Inflammation Have a Role in the Pathogenesis of Cardiac Syndrome X? A Genetic-Based Clinical Study With Assessment of Multiple Cytokine Levels
    (2016-04-01T00:00:00Z) Demir, Bulent; Onal, Burak; Ozyazgan, Sibel; Kandaz, Cemre; UZUN, Hafize; Aciksari, Gonul; Uygun, Turgut; Opan, Selcuk; Karakaya, Osman; Akkan, Ahmet Gökhan; AKKAN, AHMET GÖKHAN
    We compared Turkish patients with cardiac syndrome X (CSX) and controls with respect to serum pro- and anti-inflammatory cytokine levels, as well as the single-nucleotide polymorphisms located in the promoter regions of their related genes. This study included 111 consecutive patients angiographically diagnosed with CSX and 111 healthy controls with similar demographic characteristics. Serum interleukin (IL) 6, tumor necrosis factor (TNF-), and IL-10 levels were measured, and the genotypes of the patients and controls were determined using standard methods. Serum IL-6 and IL-10 levels were significantly higher in the CSX group than in the control group (P < .01, respectively). Serum TNF- level was lower in the CSX group than in the control group (P < .001). On the other hand, participants with CSX and healthy controls were not significantly different with respect to the genotype distributions of IL-6, TNF-, and IL-10 genes. As a result of our study, both pro-inflammatory and anti-inflammatory cytokines may play a role in the pathogenesis of CSX. In contrast, the studied gene polymorphisms did not influence CSX pathogenesis.
  • PublicationMetadata only
    Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients
    (2018-02-01T00:00:00Z) Kandaz, Cemre; Onal, Burak; Ozen, Deniz; Demir, Bulent; Akkan, Ahmet Gökhan; Ozyazgan, Sibel; AKKAN, AHMET GÖKHAN
    BackgroundDefinition of Cardiac Syndrome X (CSX) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of CSX is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis.