Person: AKKAN, AHMET GÖKHAN
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Publication Metadata only Temel ve Klinik Farmakoloji - Katzung(2021-09-01T00:00:00Z) Akkan, Ahmet Gökhan; Köse, Çağla; AKKAN, AHMET GÖKHANPublication Metadata only The Effect of Orphenadrine on Rewarding Property of Morphine-Induced Conditioned Place Preference(2020-05-01T00:00:00Z) Köse, Çağla; Bukharı, Andleeb; Akkan, Ahmet Gökhan; Özyazgan, Sibel; AKKAN, AHMET GÖKHANPublication Metadata only Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol(2021-02-01T00:00:00Z) Todurga Seven, Zeynep Gizem; Bolkent, Sema; Köse, Çağla; Çoşkun, Zeynep Mine; Gökdemir, Selim; Akkan, Ahmet Gökhan; Özyazgan, Sibel; AKKAN, AHMET GÖKHAN: In recent years, cannabinoids have been shown to have beneficial effects on diabetic vascular complica tions. Vascular complications due to fructose-induced hyperinsulinemia (HI) and diabetic vascular complications have similar mechanisms. The aim of this experimental study was to observe whether the cannabinoid agonist delta-9-te trahydrocannabinol (THC) has an ameliorating effect on fructose-induced HI and vascular responses in the aortic ring of rats with HI. Methods: A total of 24 rats were categorized into 4 groups: control (standard food pellets and water), HI (water contain ing 10% fructose provided for 12 weeks), THC (1.5 mg/kg/day intraperitoneal administration for 4 weeks), and THC+HI. Body weight was measured again on the last day of the study and the serum insulin level was measured with an en zyme-linked immunosorbent assay. The acetylcholine (ACh) maximum relaxant effect in aortic rings pre-contracted with noradrenaline (NA) was evaluated. Results: The body weight of THC and THC+HI groups was lower compared with that of the controls (p<0.01). Increased insulin level as a result of fructose consumption decreased with THC administration (p<0.01) while the glucose level increased in all other groups compared with the control group (p<0.01, p<0.05). The NA Emax value decreased in the group receiving THC treatment (p<0.01). The increased ACh pD2 value in the HI groups also decreased in the THC treatment group (p<0.0001). The decreased maximum inhibition value in the HI group increased significantly with THC administration (p<0.001). Conclusion: THC demonstrated beneficial effects on fructose-induced HI. THC improved ACh-induced endothelial dependent relaxation in HI rat aortic rings. Keywords: Endothelial-dependent relaxation, hyperinsulinemia, tetrahydrocannabinol, vascular response