Person: ARICI, DILEK SEMA
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Publication Open Access A Primary Adenosquamous Carcinoma of the Stomach: Report of Two Cases(2017-07-01) Gecer, MELİN; Unver, NURCAN; HASBAHCECI, Mustafa; Gucin, ZÜHAL; Tosuner, ZEYNEP; Akcakaya, ADEM; Arici, Sema; GEÇER, MELİN; ÜNVER, NURCAN; GÜCİN, ZÜHAL; TOSUNER, ZEYNEP; ÇOBAN, EZGİ; AKÇAKAYA, ADEM; ARICI, DILEK SEMAPrimary gastric adenosquamous carcinomas are extremely rare tumors. A gradual transition between the malignant glandular and squamous components of the tumor is seen on performing a histopathological evaluation. These tumors are known to have poorer clinical outcomes than conventional adenocarcinomas. We aimed to present two cases of primary adenosquamous carcinomas that were diagnosed at the later stage in our institute.Publication Metadata only Effects of the Chemokine Receptor 5 (CCR5)-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses and Liver Tissue Pathology in HCV Infected Patients(2014-07-01T00:00:00Z) YILMAZ, ABDULKERİM; ALAGÖZLÜ, HAKAN; ÖZDEMİR, ÖZTÜRK; Arici, Sema; ARICI, DILEK SEMABackground: The specific antiviral T cells provide CC chemokine receptor 5 (CCR5) for the immune response during the hepatitis C virus (HCV) infection. Heterogenous and/or homozygous 32 base pair deletion in CCR5 gene (CCR5 432 bpdel) leads to reduced protein expression.Publication Metadata only Epigenetic Inactivation of Tumor Suppressor SFRP2 and Point Mutation in KRAS Proto-Oncogene in Fistula - Associated Mucinous Type Anal Adenocarcinoma: Report of Two Cases(2010-01-01T00:00:00Z) ŞEN, METİN; Ozdemir, Oztuerk; TURAN, MUSTAFA; Arici, Sema; Yildiz, Fazilet; Koksal, Binnur; Goze, Fahrettin; ARICI, DILEK SEMAThe secreted frizzled-related proteins (SFRPs) genes are unmethylated in normal colorectal mucosa tissue but abberant methylation profiles can be detected in colorectal cancer (CRC), adenomas, and in aberrant crypt foci. The aim of the current study was to clarify whether SFRP2 methylation and K-ras structural mutation in fecal DNA can be found in stool and tumoral tissues of individuals with fistula-associated mucinous type anal adenocarcinomas (MTAA). Two man patients (68 and 56 years old) were treated for anorectal fistula in the surgical department. Patients were evaluated for clinical findings, tumoural tissue samples were examined histopathologically and DNA from fecal and tumoral tissue samples were isolated. K-ras mutation and promoter hypermethylation of SFRP2 gene in tumoral tissues were assessed by methylation-specific PCR based stripAssay hybridisation technique (Me-PCR) and compared to the healthy controls. Fecal and tumoural tissue samples from both patients were found to be fully hypermethylated profiles for SFRP2 gene and combined point mutations were detected in codon 12 and 13 of K-ras proto-oncogene. The current results showed that the combined effects of somatic mutations in K-ras and epigenetic alterations in SFRP2 genes may play an active role in the development of mucinous type anal adenocarcinoma.Publication Metadata only Small bowel tumors in emergency surgery(2010-07-01T00:00:00Z) TURAN, MUSTAFA; KARADAYI, KÜRŞAT; DUMAN, Mustafa; ÖZER, HATİCE; Arici, Sema; YILDIRIR, Cihan; KOCAK, Osman; ŞEN, METİN; ARICI, DILEK SEMABACKGROUNDPublication Open Access Primary pancreatic lymphoma is a rare cause of pancreatic mass: A case report(2015-09-01) BAYSAL, Birol; KAYAR, Yusuf; Ince, ALİ TÜZÜN; Arici, Sema; TURKMEN, Ihsan; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ARICI, DILEK SEMA; ŞENTÜRK, HAKANPrimary pancreatic lymphoma (PPL) is a rare entity, most likely to be clinically misdiagnosed as pancreatic cancer. The cure rate of PPL is higher compared with that of pancreatic adenocarcinoma. This is the case report of a 57-year-old male patient who was hospitalized with complaints of abdominal pain, weight loss and jaundice. The radiological evaluation revealed a pancreatic head mass and, following endoscopic ultrasound-guided fine-needle aspiration biopsy, the tumor was diagnosed as diffuse large B-cell lymphoma. The final diagnosis was PPL, and the patient went into remission after receiving three cycles of treatment with rituximab, doxorubicin, cyclophosphamide, vincristine and prednisolone (R-CHOP regimen). Therefore, PPL should be considered in the differential diagnosis of pancreatic masses and its management differs from that of other types of pancreatic tumor.Publication Open Access What does the Data of 354,725 Patients from Turkey Tell Us About Cervical Smear Epithelial Cell Abnormalities? - The Epithelial Cell Abnormality Rate is Increasing - Quality Control Studies and Corrective Activity are Musts(2017-05-01) Turkmen, Ilknur Cetinaslan; USUBÜTÜN, ALP; Cakir, Asli; Aydin, Ozlem; Bolat, Filiz Aka; Akbulut, Metin; ALTINAY, Serdar; Arici, Sema; ASLAN, Figen; Astarci, Muzeyyen; Bagir, Emine Kilic; Bas, Yilmaz; Bassullu, Nuray; CELIK, Betul; CETINER, Handan; Cobanoglu, Bengu; Aydin, Abdullah; Demir, Hale; Dogan, Hayriye Tatli; EKEN, Kamile Gulcin; ERHAN, Selma Sengiz; Erdogan, Gulgun; Sahin, Nurhan; ERDOGAN, Kivilcim Eren; Eren, Funda; Ersoz, Safak; Firat, Pinar; Gurses, Iclal; Haberal, Nihan; KAHRAMAN, Dudu Solakoglu; KAMALI, Gulcin Harman; KARABULUT, Yasemin Yuyucu; Kefeli, Mehmet; Koyuncuoglu, Meral; Koseoglu, R. Dogan; Muezzinoglu, Bahar; ONAL, Binnur; Onder, Sevgen; OZCAN, Zuhal; KIMILOGLU, Elife; Ozer, Hatice; SONMEZ, F. Cavide; Sahin, Sevinc; Yalta, Tulin; ARICI, DILEK SEMA; ŞAHİN, NURHANObjective: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories.Publication Open Access Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors(2012-09-20T00:00:00Z) ÖZER, HATİCE; Yenicesu, Goncalmir; Arici, Sema; ÇETİN, MERAL; TUNCER, ERSİN; ÇETİN, ALİ; ARICI, DILEK SEMABackground: In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle. This study was designed to evaluate immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, and bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in typing of benign, borderline, and malignant serous and mucinous ovarian tumors.Publication Metadata only Yields of Dual Therapy Containing High-Dose Proton Pump Inhibitor in Eradication of H. Pylori Positive Dyspeptic Patients(2014-07-01) Ince, ALİ TÜZÜN; TOZLU, Mukaddes; BAYSAL, Birol; Senturk, HAKAN; Arici, Sema; Ozden, Ali; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; ARICI, DILEK SEMABackground/Aims: H. pylon eradication has been recommended for dyspeptic patients in high prevalance regions. Triple therapies are still prescribed mostly because culture and antibiotic susceptibility tests aren-t widely available in the world. Dual therapy with high-dose proton pump inhibitors reported to have higher eradication rates. Our objective was to determine eradication success and cost-effectivity of dual therapy in dyspeptic patients. Methodology: Patients were treated orally with either dual (n:74,omeprazole 20mg q.i.d and amoxicillin 1g b.i.d) or triple therapy (n:116,omeprazole 20mg b.i.d and amoxicillin 1g b.i.d and clarithromycin 500mg b.i.d) for 14 days. HpSA was requested 3 months later. The results were evaluated statistically, p values <0,05 were considered significant. Results: Patients (n:190) were included the study((80 female,110 male, mean age: 35.6 11yearr). Alcohol/smoking, endoscopic findings and H. pylon rates with pathological examinations were not significantly different between groups whereas there was significant difference in HpFast tests(p<0.01). Whe examined with HpSA tests 3 months after the treatment eradication rate was 81.1% in the dual therapy group versus 63.8% in the triple therapy group (p:0.011) Dual therapy was economic than triple therapy (144USDvs.107USD,p<0.001). Conclusions: Dual therapy seems more successful cost-effective and is less risky in terms of side effects compared to standard triple therapy in patients with dyspepsia.