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ARICI, DILEK SEMA

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DILEK SEMA
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ARICI
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  • PublicationOpen Access
    A Six Sigma Trial For Reduction of Error Rates in Pathology Laboratory
    (2016-09-01) TURNA, Seval; Tosuner, ZEYNEP; Gucin, ZÜHAL; Kiran, TUĞÇE; Buyukpinarbasili, NUR; TASKIRAN, Olcay; Arici, DİLEK SEMA; TOSUNER, ZEYNEP; GÜCİN, ZÜHAL; KIRAN, TUĞÇE; BÜYÜKPINARBAŞILI, NUR; TURNA, SEVAL; ARICI, DILEK SEMA
    Objective: The aim of this study is to determine differences of levels of empathy among undergraduates in each year of their four-year programs of physiotherapy. Methods: During the 2014-2015 academic school year, 381 physiotherapy students were enlisted from two universities in Istanbul, one a foundation and the other a government university. The Turkish version of the Jefferson Scale of Physician Empathy was administered. Students were asked to indicate interest in particular physiotherapy specialties as well as their region of origin in Turkey. The Kruskal-Wallis analysis was used to determine differences among the four study years, and also to measure relationships between specialty interest, home-region, and empathy scores of the students. Empathy scores were also compared according to gender. Results: The difference of empathy scores between the students of the two universities was borderline significant (p=0.057). Empathy scores in both universities increased to a significant degree after school entrance and decreased in the final year. Levels of empathy did not change according to gender, specialty interest, or home-region (p=0.722, 0.524, and 0.309, respectively). Conclusions: This study points to the need for physiotherapy curricula that would enhance empathy and give students practice in exhibiting this valuable attribute. Additional studies are needed that would include larger study populations and track the same students year by year as to how and why their empathy levels change during their training.
  • PublicationOpen Access
    Diffusion MRI on lymph node staging of gastric adenocarcinoma
    (2015-06-01) HASBAHCECI, Mustafa; Akcakaya, ADEM; Memmi, NAİM; TURKMEN, Ihsan; Cipe, Gokhan; Yildiz, PELİN; Arici, DİLEK SEMA; MUSLUMANOGLU, Mahmut; AKÇAKAYA, ADEM; MEMMİ, NAİM; YILDIZ, PELİN; ARICI, DILEK SEMA
    Objective: The purpose of this study was to evaluate the accuracy of diffusion weighted magnetic resonance imaging (MRI) in preoperative assessment of metastatic lymph nodes of gastric cancer. Methods: A total of 23 gastric cancer patients with a mean age of 59.4±10.9 years were analyzed. Lymph nodes were grouped as perigastric lesser curvature (Group Ia), perigastric greater curvature (Group Ib), D1+/D2 lymph nodes (Group II). Identification of histologically metastatic lymph nodes by diffusion weighted MRI was regarded as the main outcome. Results: A total of 1,056 lymph nodes including 180 histologically proven metastatic lymph nodes were dissected. Although diffusion weighted MRI could identify the metastatic lymph nodes in 18 out of 23 patients (77.8%), only 69 of total 1,056 nodes (6.53%), either metastatic or non-metastatic, could be detected. There was no correlation between histopathology and diffusion weighted MRI with regard to lymph node groups (P>0.05 for all). Overall accuracy was calculated as 69.56, 65.21 and 52.17 for Groups II, Ib and Ia lymph nodes, respectively. Apparent diffusion coefficient (ADC) values could not be helpful to differentiate metastatic lymph nodes (P=0.673). Conclusions: Diffusion weighted MRI has low accuracy to detect or to differentiate metastatic and non-metastatic lymph nodes based on their ADC values in gastric cancer.
  • PublicationOpen Access
    Metachronous metastatic paraganglioma in jejunum as a rare entity: A case report
    (2015-03-01) Bektasoglu, HÜSEYİN KAZIM; CIPE, Gokhan; YARDIMCI, ERKAN; Arici, DİLEK SEMA; HASBAHCECI, Mustafa; KARATEPE, Oguzhan; MUSLUMANOGLU, Mahmut; BEKTAŞOĞLU, HÜSEYİN KAZIM; YARDIMCI, ERKAN; ARICI, DILEK SEMA
    Pheochromocytomas and paragangliomas are neuroendocrine tumors that arise from chromaffin cells of adrenal medulla and extra-adrenal paraganglia, respectively. The recurrence of these neuroendocrine tumors as a jejunal mass causing obstruction in the small intestine is an exceptional entity. The present study reports the case of a 70-year-old male who presented to the Emergency Department of Bezmialem Vakif University Hospital with abdominal pain and vomiting. The patient possessed a history of left nephrectomy due to malignant pheochromocytoma that had invaded into the left kidney eight months prior to presentation. Bowel obstruction was diagnosed and the patient underwent a laparoscopic procedure. Partial resection of the jejunum was performed and immunohistochemical studies revealed the lesion to be malignant paraganglioma. The majority of paragangliomas are chemo- and radioresistant. Surgical excision remains the primary treatment. Metachronous paraganglioma arising from the small intestine is an extremely rare entity and may be a relevant consideration in patients presenting with bowel obstruction.
  • PublicationOpen Access
    Vulvar granular cell tumor
    (2016-07-01) Sonmez, FATMA CAVİDE; KOROGLU, Nadiye; Guler, BERİL; Arici, DİLEK SEMA; SÖNMEZ, FATMA CAVİDE; GÜLER, BERIL; ARICI, DILEK SEMA
    Granular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. They generally occur as small, slow growing, and skin-colored nodule. GCTs are usually benign, but malignant cases were reported. Recurrence can be seen in benign tumors with clear margins, but rates increase with positive margins. The treatment is complete surgical excision. We report a case of benign GCT of the vulva. A 41-year-old patient presented with vulvar mass, and biopsy was consisted with GCT.
  • PublicationOpen Access
    Transforming a US scholarly concentrations program internationally: lessons learned
    (2019-04-25) Koc, Meliha Meric; Kazancioglu, RÜMEYZA; KÜÇÜKDURMAZ, FATİH; Arici, DİLEK SEMA; DiBiase, Rebecca M.; Greene, Jeremy A.; Beach, Mary Catherine; KAZANCIOĞLU, RÜMEYZA; MERİÇ KOÇ, MELİHA; ARICI, DILEK SEMA
    BackgroundScholarly Concentrations programs in U.S. medical schools aim to instill passion for critical thinking and promote careers in academic medicine. The rise of these programs has seen variable goals, structure, and outcomes. Transformation of these programs internationally is in its infancy.MethodsWe describe implementation of the Johns Hopkins School of Medicine Scholarly Concentrations program, offering Basic Science, Clinical Science, Medical Ethics/Healing Arts, History of Medicine, and Public Health/Community Service, at Bezmialem Vakif University in Istanbul, Turkey. Over six modules in the preclinical years, students develop a faculty-mentored experience which encourages the acquisition of attitudes and skills for self-directed, lifelong learning and scholarship. This culminates in abstract and project presentation. We report program characteristics (context and logistics) and outcomes (student engagement and experiences).ResultsThe Scholarly Concentrations program at Bezmialem began in 2014, with nearly two completed cohorts of students. In comparison to Johns Hopkins, students at Bezmialem begin at an earlier age (thus do not have as much prior research experience) and are subsequently evaluated for residency in terms of test scores rather than scholarship and publications, but have a similar level of intellectual curiosity and desire to take ownership of their project. Eighty-two percent of Bezmialem students stated the project they pursued was either their own idea or was an idea they formed after meeting with their mentor. Students at Bezmialem were more likely to choose Clinical Science projects (p=0.009). Only 5% of Bezmialem students in end-of-course survey felt dissatisfied with the level of ownership they experienced with their project, a frequency similar to that seen by Johns Hopkins students (2%).ConclusionsScholarly Concentrations programs play an important role in U.S. medical schools, and these programs can be successfully implemented internationally. The Scholarly Concentrations program at Johns Hopkins has been transformed to a program at Bezmialem in Istanbul, the first program outside North America or the European Union. When designing these programs, one must consider the context, logistics, student engagement, and outcomes. While long-term outcomes are needed, this can serve as a model for implementation elsewhere.
  • PublicationMetadata only
    Should Core Needle Biopsy be Used in the Evaluation of Thyroid Nodules?
    (2016-12-01) Guler, BERİL; Kiran, TUĞÇE; Arici, DİLEK SEMA; Aysan, Erhan; Sonmez, FATMA CAVİDE; GÜLER, BERIL; KIRAN, TUĞÇE; ARICI, DILEK SEMA; AYŞAN, MUSTAFA ERHAN; SÖNMEZ, FATMA CAVİDE
    Fine needle aspiration (FNA) is the first choice in thyroid nodules suspected of harboring malignancy on sonography in routine practice. However, sampling with core needle biopsy (CNB) is also being used, especially in cases with repeated nondiagnostic/indeterminate diagnoses. The aim of this study was the retrospective evaluation of CNB samples. A total of 604 thyroid CNB samples registered in the Department of Pathology at Bezmialem Foundation University Medical Faculty within the 1-year period between June 2014 and June 2015 were re-evaluated by correlation with previous FNA and later resection results. CNB was divided into diagnostic groups of insufficient, malignant, suspicious for malignancy, no evidence of malignancy/benign, atypia of uncertain significance (AUS)/follicular lesions of uncertain significance (FLUS), and follicular neoplasm (FN)/suspicious for follicular neoplasm (SFN). Among the 604 cases, 15 cases (2.48 %) were classified as malignant and 9 cases (1.49 %) as suspicious for malignancy. No evidence of malignancy was seen in 512 cases (84.76 %). There were 26 (4.3 %) cases in the AUS/FLUS-FN/SFN group, and the sample was inadequate in 42 cases (6.95 %). Resection was performed for 17 of the cases classified as malignant or suspicious for malignancy, and all were found to be malignant. There were also 10 resected cases with a diagnosis of no evidence of malignancy, and all were found to be benign. We think that sampling with CNB may be useful especially in repeating inadequate biopsies or cases diagnosed with AUS/FLUS that have hesitations regarding clinical management. Larger series including comparisons with FNA and resection results are required.
  • PublicationOpen Access
    Carcinoid tumor arising in a mature cystic teratoma: A case report
    (2015-05-01) Tosuner, ZEYNEP; Sonmez, FATMA CAVİDE; Arici, DİLEK SEMA; Dansuk, RAMAZAN; TOSUNER, ZEYNEP; SÖNMEZ, FATMA CAVİDE; ARICI, DILEK SEMA; DANSUK, RAMAZAN
    Mature cystic teratomas are common benign tumors of the ovary. The most common form of malig‑ nant transformation is squamous cell carcinoma, however, malignant transformation is rarely observed and cases are usually asymptomatic. Carcinoid tumors are rare tumors of the neuroendocrine system. A number of the carcinoids result in clinical syndromes due to the secretion of vasoac‑ tive substances produced by the tumor. A 75‑year‑old woman suffering from groin pain was admitted to the Faculty of Medi‑ cine at Bezmialem Vakıf University (Istanbul, Turkey). An adnexal mass was detected during the physical examination. Magnetic resonance imaging scans exhibited an 8x7‑cm mass in the right ovary. Surgical excision of the mass was performed and histopathological examination revealed a mature cystic teratoma with three germ layers. An area consisting of nests and trabeculae was evident in the cyst wall. The pathological diagnosis was of an insular and trabecular variant of carcinoid tumor arising in a mature cystic teratoma. The patient did not present with carcinoid syndrome, and no recurrence was observed after 11 months of follow‑up examinations
  • PublicationMetadata only
    Apoptotic effects of topical antiglaucoma medications on conjunctival epithelium in glaucoma patients
    (2014-01-01) ARICI, MUSTAFA KEMAL; Arici, DİLEK SEMA; Ozec, Ayse Vural; DURSUN, AYHAN; TOKER, MUSTAFA İLKER; ERDOĞAN, HAYDAR; ARICI, MUSTAFA KEMAL; ARICI, DILEK SEMA
    Purpose: In this study, we aimed to investigate the apoptotic effects of topical antiglaucoma medications on the conjunctival epithelium.
  • PublicationMetadata only
    Mature ovarian cystic teratoma containing well-differentiated cerebellar tissue
    (2017-01-01) SONMEZ, F. Cavide; YILDIZ, PELİN; KIRAN, TUĞÇE; Arici, DİLEK SEMA; DANSUK, RAMAZAN; YILDIZ, PELİN; KIRAN, TUĞÇE; ARICI, DILEK SEMA; DANSUK, RAMAZAN
    A 38-year-old female patient experienced groin pain; ultrasound imaging revealed a dermoid cystic mass in the right ovary and a cystectomy was then performed. Unusually, a mature cerebellum is found in the cyst wall. The pathological diagnosis was -mature cystic teratoma with well-differentiated cerebral and cerebellar tissue-. Glial tissue is a common neural component of teratomas, but a cerebellum is extremely rare in mature ovarian cystic teratomas. The authors report the case because of its rare component; they acknowledge that a cystic teratoma is the most common neoplasm of ovarian germ cells.
  • PublicationOpen Access
    General Overview of Renal Cell Carcinoma with the Evaluation of our cases
    (2015-12-01) Yildiz, PELİN; Sonmez, FATMA CAVİDE; Buyukpinarbasili, NUR; Gucin, ZÜHAL; Arici, DİLEK SEMA; KOCAKOC, Ercan; Akcay, MUZAFFER; YILDIZ, PELİN; SÖNMEZ, FATMA CAVİDE; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ARICI, DILEK SEMA; AKÇAY, MUZAFFER
    Objective: Renal cell carcinoma (RCC) is the 14th most common tumor in the world. In 2010, the protocol for the examination of kidney specimens with invasive carcinoma of renal tubular origin was updated. The aim of our study was to review 1-year RCC patients of our hospital according to the new protocol, classification, and staging systems with respect to their morphological and immunohistochemical features.. Methods: The medical records of 54 RCC patients between July 2012 and July 2013 were retrospectively reviewed. They were classified according to the WHO 2004 classification system and newly defined subtypes. The following variables were determined in each case: age, sex, histological subtype, stage, and Fuhrman nuclear grade. Results: In our study, 30 (55.6%) men and 24 (44.4%) women were diagnosed with RCC out of 54 patients. The median age was 56 years. In total, 21 patients had (55.2%) right-and 17 had (44.74%) left-sided tumors. Thirty-eight (70.3%) clear cell, 6 (11.1%) papillary, 7 (12.96%) chromophobe, 1 (1.85%) multilocular, 1 (1.85%) unclassified, and 1 (1.85%) tubulocystic RCC were seen. According to primary tumor, 33 (61.1%) pT1, 10 (18.51%) pT2, 9 (16.66%) pT3, and 2 (3.70%) pT4 patients were reported. Chromophobe RCCs were excluded from the Fuhrman grading (G) system; of the remaining 2 (4.17%) were G1, 30 (62.5%) were G2, 13 (27.08%) were G3, and 3 (6.25%) were G4 tumors. Conclusion: Although RCC constitutes the majority of renal tumors, different subtypes are also encountered. In our study, clear cell RCCs were the most common type of tumors consistent with the literature. The remarkable point was that chromophobe RCCs were more frequent in our study. Because of infrequency, more examples are required to distinguish newly defined subtypes.