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GÖNCÜ, BEYZA SERVET

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BEYZA SERVET
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GÖNCÜ
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Now showing 1 - 10 of 10
  • PublicationMetadata only
    A COMPARATIVE STUDY OF PARATHYROID TRANSPORT SOLUTION AND UNIVERSITY OF WISCONSIN SOLUTION: EFFECT ON CALCIUM-SENSING RECEPTOR AND VITAMIN-D RECEPTOR DURING COLD ISCHEMIA IN PARATHYROID TISSUE
    (2019-10-01) Goncu, Beyza; Yucesan, Emrah; Ozdemir, Burcu; Akbaş, Fahri; Kazancıoğlu, Rümeyza; Aysan, Erhan; GÖNCÜ, BEYZA SERVET; AKBAŞ, FAHRİ; KAZANCIOĞLU, RÜMEYZA
  • PublicationMetadata only
    Graft survival effect of HLA-A allele matching parathyroid allotransplantation.
    (2020-12-22T00:00:00Z) Goncu, Beyza; Salepcioglu Kaya, Harika; Yucesan, Emrah; Ersoy, Yeliz Emine; Akcakaya, Adem; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKÇAKAYA, ADEM
  • PublicationOpen Access
    Xenotransplantation of Microencapsulated Parathyroid Cells as a Potential Treatment for Autoimmune-Related Hypoparathyroidism.
    (2021-08-09T00:00:00Z) Yucesan, Emrah; Basoglu, Harun; Goncu, Beyza; Gul, Burcu; Aysan, Erhan; Ersoy, Yeliz Emine; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; GÜL, BURCU
  • PublicationMetadata only
    Efficacy of xenotransplantation without immunosuppression in rats
    (2019-01-01T00:00:00Z) Goncu, Beyza; KANIMDAN, EBRU; YÜCESAN, Emrah; Ozdemir, Burcu; Idiz, Oguz; ERSOY, YELİZ EMİNE; AKBAŞ, FAHRİ; Aysan, Erhan; KANIMDAN, EBRU; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; ERSOY, YELIZ EMINE; AKBAŞ, FAHRİ
    Purpose: .The aim of this study was to transplant hyperplastic cells obtained from human parathyroid tissues into the rats without immunsupression, and also evaluate the efficiency.
  • PublicationMetadata only
    Fresh Tissue Parathyroid Allotransplantation from a Cadaveric Donor without Immunosuppression: A 3-Year Follow-Up
    (2020-04-01T00:00:00Z) Aysan, Erhan; YÜCESAN, Emrah; Idiz, Ufuk Oguz; AYŞAN, MUSTAFA ERHAN; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET
  • PublicationOpen Access
    Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells
    (2020-09-01T00:00:00Z) Goncu, Beyza; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA; Gokay, Guzin; ÖZTEN KANDAŞ, NUR; GÖNCÜ, BEYZA SERVET; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA; ÖZTEN KANDAŞ, NUR
    Lichens are stable symbiotic associations between fungus and algae and/or cyanobacteria that have different biological activities. Around 60% of anti-cancer drugs are derived from natural resources including plants, fungi, sea creatures, and lichens. This project aims to identify the apoptotic effects and proliferative properties of extracts ofBryoria capillaris (Ach.) Brodo&D.Hawksw,Cladonia fimbriata (L.) Fr.,Evernia divaricata (L.) Ach.,Hypogymnia tubulosa (Schaer.) Hav.,Lobaria pulmonaria (L.) Hoffm., andUsnea florida (L.) Weber ex Wigg. lichen species on prostate cancer cells. Lichen extracts were performed by ethanol, methanol, and acetone separately by using the Soxhlet apparatus and the effects of the extracts on cell viability, proliferation, and apoptosis were measured with the utilization of MTT, LDH assay, Annexin V assay, and Western Blot. Findings of our study revealed a positive correlation between the elevation of cell sensitivity and the increase in the treatment doses of the extract in that higher doses applied reverberate to higher cell sensitivity. A similar correlation was also identified between cell sensitivity elevation and the duration of the treatment. Evidence in our study have shown the existence of an anti-proliferative effect in the extracts ofBryoria capillaris,Evernia divaricata (L.) Ach.,Hypogymnia tubulosa (Schaer.) Hav.,Lobaria pulmonaria (L.) Hoffm., andUsnea florida (L.) Weber ex Wigg., while a similar effect was not observed in the extracts ofCladonia fimbriata.Evernia divaricatainduced anti-proliferative and apoptotic effects in PC-3 cells,whichinduced apoptotic cell death by both extrinsic and intrinsic pathways.Hypogymnia tubulosahas been shown to have anti-proliferative and apoptotic effects in all extractions methods and our findings identified that both the percentage of the apoptotic cells and apoptotic protein expressions recorded an increase at lower treatment concentrations. AlthoughLobaria pulmonariais known to have significant cytotoxic effects, we did not observe a decrease in cell proliferation. Indeed, proliferation marker proliferating cell nuclear antigen (PCNA) protein expression levels have shown an increase in all extracts, whileUsnea florida exhibitedapoptosis induction and slight proliferation reduction in extract treatments with lower concentrations. We tested 18 extracts of six lichen species during our study. Of these,Evernia divaricataandHypogymnia tubulosademonstrated significant apoptotic activity on prostate cancer cells including at low concentrations, which implies that it is worth pursuing the biologically active lead compounds of these extracts on prostate cancerin vitro. Further corroboratory studies are needed to validate the relative potential of these extracts as anti-metastatic and anti-tumorigenic agents.
  • PublicationMetadata only
    MINOR HISTOCOMPATIBILITY ANTIGEN SP110: AN EVOLUTIONARY TRACE FOR PARATHYROID TISSUE
    (2019-10-01T00:00:00Z) Goncu, Beyza; YÜCESAN, Emrah; Idiz, Ufuk Oguz; AKBAŞ, FAHRİ; Aysan, Erhan; Kandas, Nur Ozten; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ; ERSOY, YELIZ EMINE
  • PublicationMetadata only
    Comparison of the efficacy of low-level laser therapy and photodynamic therapy on oral mucositis in rats
    (2019-09-01T00:00:00Z) Alinca, Suzan Bayer; Saglam, Ebru; ÖZTEN KANDAŞ, NUR; Okcu, Oguzhan; YILMAZ, NERGİZ; Doğan, Mehmet Ali; SAĞLAM, EBRU; ÖZTEN KANDAŞ, NUR; GÖNCÜ, BEYZA SERVET
    Cancer treatment with chemotherapy or radiotherapy is associated with some side effects including in the oral cavity. One of the more significant oral complications is oral mucositis (OM) which induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking. Although advancements in cancer treatment improved the survival rate, severe OM and opportunistic infection affect treatment adversely. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and photodynamic therapy (PT) are noninvasive methods that reduce inflammation and pain during wound healing. The aim of this study is to evaluate immunohistochemical and histological examination of the OM region of the PT comparing LLLT. In this study, 24 Sprague-Dawley rats were divided into three groups as control, LLLT, and PT groups. All groups received 5-fluorouracil intraperitoneally and a linear trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the LLLT group was administered LLLT, and the PT group had LLLT after indocyanine green application. Then all groups were sacrificed, and histological analyses and protein level detection of basic fibroblast growth factor (bFGF), transforming growth factor (TGF-beta), and platelet-derived growth factor (PDGF-BB) were evaluated in all groups. PT was determined to be more statistically significantly than LLLT with bFGF and PDGF-BB. However, regarding TGF-beta, no statistically significant difference was observed between the groups. Within the limitations of this study, indocyanine green may accelerate the LLLT effect. However, further studies on this subject are required.
  • PublicationMetadata only
    A New Transport Solution for Parathyroid Allotransplantation: Effects on Cell Viability and Calcium-Sensing Receptors.
    (2018-08-01T00:00:00Z) Goncu, Beyza; Yucesan, Emrah; Ozdemir, Burcu; Basoglu, Harun; Kandas, Nur Ozten; Akbas, Fahri; Aysan, Erhan; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ
    Background: Cold ischemia protects organs and tissues by slowing their metabolism, but it also causes ischemic injury. Minimizing cold ischemia has been an important goal in parathyroid auto- and allotransplantation, as well as the transplantation of other major organs. Parathyroid glands are responsible for calcium homeostasis by releasing parathormone (PTH) into the blood circulation. Functionality of a new parathyroid transport solution (NPTS) and effects on cell viability, PTH secretion, and calcium-sensing receptor (CaSR) levels during cold ischemia were evaluated. Materials and Methods: A NPTS was prepared, and the pH was adjusted to a range of 7.2-7.4 and kept at +4 degrees C until use. Seven patients with parathyroid hyperplasia secondary to chronic renal failure who were scheduled to undergo subtotal parathyroidectomy were enrolled in the study. Glands were cold-preserved in NPTS with different time intervals (0, 6, 12, 18, and 24 hours), and then parathyroid cell viability before and after cryopreservation, PTH secretion, and CaSR levels were determined. Results: The mean cell viability before cryopreservation was 92.7% (range 89.2%-97.2%). There were no significant differences in cell viability rates before and after cryopreservation (p=0.1168 and p=0.4085, respectively), and CaSR levels (p=0.5446) were not significant. Conclusions: NPTS is a solution designed specifically for parathyroid tissue transplantation. This patent pending product can support cellular viability and PTH release, as well as protect CaSR functionality for up to 24 hours of cold ischemia.
  • PublicationOpen Access
    GLUT-Targeting Phototherapeutic Nanoparticles for Synergistic Triple Combination Cancer Therapy.
    (2023-02-12T21:00:00Z) Cetin Ersen, Busra; Goncu, Beyza; Dag, Aydan; Birlik Demirel, Gokcen; DAĞ, AYDAN; GÖNCÜ, BEYZA SERVET
    The combination of multimodal therapies into one nanocarrier system is promising for its potential to enhance treatment performance by overcoming the efficacy problems encountered in conventional monomodal therapy. In this study, targeted and multimodal therapeutic hybrid nanocarriers are fabricated for breast cancer treatments. In this context, the synthesized gold nanorods (AuNRd), photothermal therapy (PTT) agent, are coated with doxorubicin (DOX) conjugated, targeted, and biocompatible tetrablock glycopeptide (P(DMAEMA--HMBAMA--FrucMA)--P(Lys)/DOX, P-DOX) polymer. Here, fructose-based (Fruc) glycopeptide polymer enhances cellular uptake into breast cancer through GLUT5. A photosensitizer molecule, indocyanine green (ICG), was loaded into the particles to provide photodynamic therapy (PDT) upon NIR light at 808 nm. In the final step of the fabrication, the polymer-coated nanoparticles are integrated with antisense ISIS5132 oligonucleotides to prevent apoptotic resistance of cells against drug molecules. The biocompatibility and therapeutic efficacy of the nanoparticles are evaluated on both human normal skin fibroblast cell (CCD-1079Sk) and human breast cancer cell (MCF7) lines. These multimodal therapeutic AuNRd@P-DOX/ICG/ISIS5132 nanoparticles demonstrate an efficient triple synergistic effect of chemo-/PTT/PDT, which is desired for breast cancer treatment. We believe that this promising multimodal therapeutic nanoparticle system can promote the further clinical application in the treatment of breast cancer and can also be adapted to other types of cancer.