2018-12-16T00:00:00Z, MUNGAN, NİL CEREN, ÖMEROĞLU YEL, BEGÜMHAN, İÇEN, HAYRUNİSA, KAYA, MUSTAFA SARP, GÜNEŞ, FATMA ESRA, AKYÜZ, SERAP HATİCE, KAYA, MUSTAFA SARP

2018-10-01T00:00:00Z, OKTAY, NİHAL ŞEHKAR, TÜRKYILMAZ, İSMET BURCU, KAYA, MUSTAFA SARP, AKYÜZ, SERAP HATİCE, YANARDAĞ, REFİYE, YARAT, AYŞEN, KAYA, MUSTAFA SARP

Amiodarone a pharmaceutical used for the treatment of arrhythmias, causes many side effects. S-Methylmethionine sulfonium is a derivative of methionine and it is widely referred to as vitamin U (Vit U). In the peer-reviewed literature there is no study reported which focuses on the protective effects of Vit U against amiodarone-s side effects on gingiva. In this study, we aimed to investigate the oxidative and inflammatory effect of amiodarone or putative protective role of Vit U on gingiva tissue. Rats were randomly divided into four groups as follows: control group: rats received corn oil; control+Vit U treated group (50 mg/kg/day); amiodarone group (100 mg/kg/day) and amiodarone+Vit U treated group (in same dose). Amiodarone and Vit U were given orally for 7 days. Vit U was given 1 h prior to the administration of amiodarone. Gingival tissues were taken from animals and homogenized in 0.9% NaCl. Lipid peroxidation and sialic acid levels were increased significantly, glutathione levels and superoxide dismutase activities were decreased significantly in the amiodarone group when compared with the control groups. Vit U combination with amiodarone reversed these effects. These results demonstrate that administration of Vit U may have protective effects on gingiva in amiodarone treatment by decreasing oxidative stress.

2018-11-16T00:00:00Z, ÖMEROĞLU YEL, BEGÜMHAN, İÇEN, HAYRUNİSA, Mungan, Nil Ceren, KAYA, MUSTAFA SARP, GÜNEŞ, FATMA ESRA, AKYÜZ, SERAP HATİCE, KAYA, MUSTAFA SARP

2017-11-01T00:00:00Z, Kaya, MUSTAFA SARP, Guclu, B., Schimmel, M., AKYÜZ, SERAP HATİCE, KAYA, MUSTAFA SARP

The unappealing taste of the chewing material and the time-consuming repetitive task in masticatory performance tests using artificial foodstuff may discourage children from performing natural chewing movements. Therefore, the aim was to determine the validity and reliability of a two-colour chewing gum mixing ability test for masticatory performance (MP) assessment in mixed dentition children. Masticatory performance was tested in two groups: systemically healthy fully dentate young adults and children in mixed dentition. Median particle size was assessed using a comminution test, and a two-colour chewing gum mixing ability test was applied for MP analysis. Validity was tested with Pearson correlation, and reliability was tested with intra-class correlation coefficient, Pearson correlation and Bland-Altman plots. Both comminution and two-colour chewing gum mixing ability tests revealed statistically significant MP differences between children (n = 25) and adults (n = 27, both P < 0.01). Pearson correlation between comminution and two-colour chewing gum mixing ability tests was positive and significant (r = 0.418, P = 0.002). Correlations for interobserver reliability and test-retest values were significant (r = 0.990, P = 0.0001 and r = 0.995, P = 0.0001). Although both methods could discriminate MP differences, the comminution test detected these differences generally in a wider range compared to two-colour chewing gum mixing ability test. However, considering the high reliability of the results, the two-colour chewing gum mixing ability test can be used to assess masticatory performance in children, especially at non-clinical settings.