Person: KURTCAN, SERPİL
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Publication Metadata only Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension(2019-05-01) Yilmaz, TEMEL FATİH; Aralasmak, AYŞE; Toprak, HÜSEYİN; MEHDI, Elnur; KOCAMAN, Gulsen; Kurtcan, SERPİL; Kaya, MEHMET ONUR; Alkan, ALPAY; YILMAZ, TEMEL FATİH; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; KURTCAN, SERPİL; KAYA, MEHMET ONUR; ALKAN, ALPAYPurpose To search for CSF dynamics of idiopathic intracranial hypertension (IIH) and communicating hydrocephalus and any correlation between MRI findings, CSF metrics and CSF opening pressure in IIH.Publication Metadata only Auditory Pathway Features Determined by DTI in Subjects with Unilateral Acoustic Neuroma(2016-12-01) KURTCAN, SERPİL; Alkan, ALPAY; Kilicarslan, R.; BAKAN, A. A.; TOPRAK, HÜSEYİN; ARALASMAK, AYŞE; AKSOY, FEYZA MÜBERRA; Kocer, A.; KURTCAN, SERPİL; ALKAN, ALPAY; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞEIn the studies concerning the pathology of the auditory pathway in the vestibulocochlear system, few use advanced neuroimaging applications of magnetic resonance imaging (MRI) such as diffusion tensor imaging (DTI). Those who did use reported DTI changes only at the lateral lemniscus and inferior colliculus level. The aim of our study was to determine diffusion changes in the bilateral auditory pathways of subjects with unilateral acoustic neuroma (AN) and compare them with healthy controls.Publication Metadata only MRS features during encephalopathic crisis period in 11 years old case with GA-1(2015-05-01) Kurtcan, SERPİL; AKSU, Banu; Alkan, ALPAY; GULER, Serhat; Iscan, AKIN; KURTCAN, SERPİL; ALKAN, ALPAY; İŞCAN, AKINGlutaric aciduria type-1 (GA-1) is a disorder of amino acid metabolism. The usual clinical-onset is an acute encephalopathic crisis in early childhood. There are only a few cases diagnosed in older age groups. MRI features of the disease are well defined. However, there are limited number of studies concerning advanced neuroimaging findings. We present DWI and MRS findings of an 11 year-old GA-1 patient admitted with an encephalopathic crisis. Diffusion restrictions in bilateral basal ganglia, corpus callosum and periventricular deep white matter were observed. In left occipital periventricular white matter and left basal ganglia, mild increased Cho/Cr and MI/Cr ratios and decreased NAA/Cr ratio were detected. Also inverted double lactate peak (TB: 135 ms) was present at 1.33 ppm in the left basal ganglia. In addition to these findings, a peak at 1.56 ppm above the baseline was seen on both short and long echo-time MRS in left occipital lobe deep white matter which may show accumulation of degradation products of amino acids in the GCDH enzyme deficiency. (Cd) 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.Publication Metadata only Evaluation of Auditory Pathways Using DTI in Patients Treated with Gamma Knife Radiosurgery for Acoustic Neuroma: A Preliminary Report(2018-09-01) Kurtcan, SERPİL; Hatiboglu, MUSTAFA AZİZ; Alkan, ALPAY; Toprak, HÜSEYİN; Seyithanoglu, MEHMET HAKAN; Aralasmak, AYŞE; Atasoy, BAHAR; Uysal, Omer; KURTCAN, SERPİL; HATİBOĞLU, MUSTAFA AZİZ; ALKAN, ALPAY; TOPRAK, HÜSEYİN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; ATASOY, BAHAR; UYSAL, ÖMERPurpose We aimed to evaluate the change in bilateral auditory pathways using diffusion tensor imaging (DTI) after gamma knife radiosurgery (GKR) and to determine the relationship between the radiosurgical treatment variables and DTI findings.Publication Metadata only Cavernous Sinus: A Comprehensive Review of its Anatomy, Pathologic Conditions, and Imaging Features(2015-06-01) BAKAN, A. A.; Alkan, ALPAY; KURTCAN, SERPİL; ARALASMAK, AYŞE; TOKDEMIR, SEVİL; MEHDI, E.; OZDEMIR, HÜSEYİN; ALKAN, ALPAY; KURTCAN, SERPİL; ARALAŞMAK, AYŞE; TOKDEMİR, SEVİL; ÖZDEMİR, HÜSEYINThe purpose of this article was to review the anatomy of the cavernous sinus (CS), illustrate numerous lesions that can affect the CS, and emphasize the imaging characteristics for each lesion to further refine the differential diagnoses. The CS, notwithstanding its small size, contains a complicated and crucial network that consists of the carotid artery, the venous plexus, and cranial nerves. The wide-ranging types of pathologies that can involve the CS can be roughly classified as tumoral, congenital, infectious/inflammatory/granulomatous, and vascular. Conditions that affect the CS usually lead to symptoms that are similar to each other; thus, for diagnosis, imaging procedures are required. Radiological evaluations are also required to detect pre- and postoperative CS invasion. Magnetic resonance imaging, which can be supplemented with thin-section contrast-enhanced sequences, is the preferred imaging technique for evaluating the CS. For correct diagnosis of CS lesions and accurate evaluations of CS invasions, it is essential to carefully analyze the anatomical structures within the CS and to acquire precise knowledge about the imaging features of CS lesions, which may frequently overlap.Publication Metadata only Neuroimaging Features of Acquired Metabolic and Toxic Encephalopathies(2018-01-01) EDIZ, Suna Sahin; Kurtcan, SERPİL; Alkan, ALPAY; Aydin, SİNEM; Tüzün, Umit; Toprak, HÜSEYİN; Aralasmak, AYŞE; KURTCAN, SERPİL; ALKAN, ALPAY; AYDIN, SİNEM; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞEBackground: Toxic and metabolic encephalopathies are easily misinterpreted or overlooked in daily neuroimaging practices.Publication Metadata only Diffusion tensor imaging findings of the brainstem in subjects with tonsillar ectopia(2018-03-01) Kurtcan, SERPİL; Alkan, ALPAY; YETIS, Huseyin; TÜZÜN, Umit; Aralasmak, AYŞE; Toprak, HÜSEYİN; Ozdemir, HÜSEYİN; KURTCAN, SERPİL; ALKAN, ALPAY; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; ÖZDEMİR, HÜSEYINWe aimed to evaluate the differences between apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) values obtained from different cranial sites in subjects with Chiari I Malformation (CM-I) and borderline tonsillar ectopia (BTE), and to determine correlations between diffusion tensor imaging (DTI) metrics and the severity of tonsillar ectopia. A total of 73 subjects with CM-I and BTE and 35 control underwent MRI and DTI. In our study, ADC values measured from the level of medulla oblongata and the RD values measured in middle cerebellar peduncles, thalamus, and globus pallidus were higher in CM-I patients than in controls. FA values at the medulla oblongata level and AD values at the medulla oblongata and pons level higher in patients with CM-I. ADC and AD values measured at the pons level were higher in BTE subjects than in controls. Compared with BTE, the CM-I subjects- ADC values at the medulla oblongata and AD values at the pons level were higher. In addition, FAs at the pons and medulla oblongata level were higher. At the medulla oblongata level, a positive correlation was observed between ADC and the size of tonsillar ectopia. AD and FA values measured at the level of medulla oblongata and pons were positively correlated with the size of tonsillar ectopia. These findings may be related to the severity of microstructural changes involving neuronal tracts at the brainstem level due to tonsillar ectopia. DTI may be useful in determining the extent of microstructural changes at the tissue level in subjects with tonsillar ectopia.Publication Open Access Craniocervical Dissections: Radiologic Findings, Pitfalls, Mimicking Diseases: A Pictorial Review(2018-01-01) MEHDI, Elnur; Aralasmak, AYŞE; Toprak, HÜSEYİN; Yildiz, Seyma; Kurtcan, SERPİL; Kolukisa, MEHMET; Asil, TALİP; Alkan, ALPAY; ARALAŞMAK, AYŞE; TOPRAK, HÜSEYİN; YILDIZ, ŞEYMA; KURTCAN, SERPİL; KOLUKISA, MEHMET; ASİL, TALIP; ALKAN, ALPAYBackground: Craniocervical Dissections (CCD) are a crucial emergency state causing 20% of strokes in patients under the age of 45. Although DSA (digital substraction angiography) is regarded as the gold standard, noninvasive methods of CT, CTA and MRI, MRA are widely used for diagnosis. Aim: Our aim is to illustrate noninvasive imaging findings in CCD. Conclusion: Emphasizing on diagnostic pitfalls, limitations and mimicking diseases.Publication Metadata only Relationship between the corpus callosum and neurocognitive disabilities in children with NF-1: diffusion tensor imaging features(2016-11-01) Aydin, SİNEM; Kurtcan, SERPİL; Alkan, ALPAY; GULER, Serhat; FILIZ, Mekiya; YILMAZ, TEMEL FATİH; SAHIN, Turkan Uygur; Aralasmak, AYŞE; AYDIN, SİNEM; KURTCAN, SERPİL; ALKAN, ALPAY; YILMAZ, TEMEL FATİH; ARALAŞMAK, AYŞEPurpose: Mild neurocognitive disabilities are commonly observed in children with neurofibromatosis type 1 (NF-1). Enlargement of the corpus callosum (CC) is one of the findings in NF-1, but the pathogenesis has not yet been clarified. In this study, we investigated whether diffusion tensor imaging (DTI) features of CC differed between children with NF-1 and healthy control subjects, and we tried to evahlate the association between the microstructural integrity of CC and neurocognitive disabilities, based on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values.Publication Metadata only Diffusion Tensor Imaging Parameters in Children with Acute Hyperammonemic Encephalopathy due to Urea Cycle Enzyme Defects and Organic Acidemia(2018-01-01) Kurtcan, SERPİL; Alkan, ALPAY; Toprak, HÜSEYİN; Demirkol, Demet; Tüzün, Umit; Aralasmak, AYŞE; KURTCAN, SERPİL; ALKAN, ALPAY; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞEBackground: Prolonged hyperammonemia, as a result of its toxic effect, may cause irreversible damage in the central nervous system.