Person:
DOĞAN, REMZI

Profile Picture
Status
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
REMZI
Last Name
DOĞAN
Name
Email Address
Birth Date

Filters

2014 - 201982020 - 20223
Reset filters

Settings

Has files: true ×

Search Results

Now showing 1 - 10 of 11
  • Thumbnail Image
    PublicationOpen Access
    Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.
    (2020-11-01T00:00:00Z) Doğan, R; Hafız, AM; Gucin, Z; Ozer, OF; Ozturan, O; Yenigun, Alper; DOĞAN, REMZI; GÜCİN, ZÜHAL; ÖZER, ÖMER FARUK; YENİGÜN, ALPER; ÖZTURAN, ORHAN
  • Thumbnail Image
    PublicationOpen Access
    Dry Eye and Dry Nose Caused by the Effect of Allergic Rhinitis on Tear and Nasal Secretion Osmolarity.
    (2020-03-17T00:00:00Z) Elbay, A; Yenigun, A; Ozturan, O; Bayraktar, H; Ozer, Ömer Faruk; Dogan, R; YENİGÜN, ALPER; ELBAY, AHMET; ÖZDEM, ABDULLAH; ÖZER, ÖMER FARUK; DOĞAN, REMZI; ÖZTURAN, ORHAN
    Objective: Allergic rhinitis is a type 1 hypersensitivity reaction of immunoglobulin E in the rhino-ocular mucosa. This study was planned to demonstrate in patients with allergic rhinitis to evaluate changes in tear, nasal secretions, and blood osmolarity compared to healthy individuals. Method: Forty allergic rhinitis patients, 25 patients with acute upper respiratory tract infections, and 26 healthy participants were included in the study. Positive patients with allergic symptoms and skin prick test results were included in the allergic rhinitis group. Tear, nasal secretion, and blood osmolarity values were examined for the 3 groups. Result: In patients with allergic rhinitis, tear and nasal secretion osmolarity values were significantly higher in patients with acute upper respiratory tract infections and those of the healthy participants (P ¼ .001, P ¼ .038). In blood osmolarity measurements, there was no statistical difference between the groups (P ¼ .489). In patients with allergic rhinitis, Schirmer test results were significantly shorter than patients who had acute upper respiratory tract infection and those of the healthy participants (P ¼ .001, P ¼ .001). Patients with allergic rhinitis and acute upper respiratory tract infections had significantly shorter Schirmer test results than in healthy participants (P ¼ .001, P ¼ .001). Conclusion: Tear osmolarity was increased in allergic rhinitis patients, and this was thought to lead to dry eye findings. In the presence of allergic rhinitis, nasal secretions were found more hyperosmolar than tears. Nasal secretion osmolarity was higher in allergic rhinitis patients than in patients with acute upper respiratory tract infections and control group.
  • Thumbnail Image
    PublicationOpen Access
    Effect of Radiofrequency on DNA Damage and Oxidative Status in Patients with Turbinate Hypertrophy.
    (2019-11-01) Tugrul, S; Koçyiğit, A; Senturk, E; Doğan, Remzi; Eren, SB; Ozturan, ORHAN; Kesgin, S; ŞENTÜRK, EROL; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN; KOÇYİĞİT, ABDÜRRAHİM
    The radiofrequency devices that are used generate radiofrequency in the frequency range of 1.5 and 2.5 MHz. This study aims to demonstrate whether systematic oxidative status and DNA are influenced in this frequency range. In study, 27 patients who received radiofrequency treatment on inferior turbinate as they were diagnosed with inferior turbinate hypertrophy. DNA damage was assessed by alkaline comet assay in peripheral lymphocyte cells. Plasma levels of total antioxidant status (TAS), total oxidative status (TOS) were determined by using an automated measurement method and oxidative stress index (OSI) was calculated (OSI was calculated as: OSI = (TOS/TAS) × 100). There were increased in the OSI and TOS values on days 1 and 15 as compared to the samples taken before the radiofrequency administration. Significant decreases were seen in TAS values on days 1 and 15. As for the DNA damage, no significant differences were found on day 15 compared to the preoperative values even though there was a statistically insignificant increase on day 1. Administration of radiofrequency radiation on inferior turbinates results in increased oxidative stress in the acute period and a decrease in the anti-oxidative system. Although this effect causes a slight increase in the DNA damage in the early post-operative period, the damage is restored to the pre-operative levels on day 15. Therefore, we believe that a more conservative approach should be selected for radiofrequency treatment instead of using it routinely.
  • Thumbnail Image
    PublicationOpen Access
    Use of Topical Tranexamic Acid to Reduce Drainage Output After Thyroidectomy
    (2022-04-01T00:00:00Z) AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, Vildan Betül; Goktas, Seda Sezen; Ozdem, Abdullah; DOĞAN, Remzi; ÖZTURAN, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; ÖZDEM, ABDULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN
    Objective: Thyroid surgery is one of the frequent surgeries in daily operation schedules more often since the thyroid gland is very vascular Hematomas after thyroidectomy may cause airway obstruction, which is life-threatening and requires immediate surgical intervention. Therefore, many hemostatic devices and methods have been developed. Tranexamic acid is a synthetic lysine analog with low molecular weight. This study was planned to demonstrate the effect of intraoperative topical tranexamic acid on postoperative drainage output for thyroid surgery.
  • Thumbnail Image
    PublicationOpen Access
    DNA damage and oxidative status in PFAPA syndrome
    (2015-10-01) TUGRUL, Selahattin; Dogan, REMZİ; Kocyigit, ABDÜRRAHİM; Torun, EMEL; SENTURK, EROL; Ozturan, ORHAN; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; KOÇYİĞİT, ABDÜRRAHİM; TORUN, EMEL; ŞENTÜRK, EROL; ÖZTURAN, ORHAN
    Objective: PFAPA syndrome is a clinical entity of unknown etiology which presents with periodic episodes of fever, aphthous stomatitis, tonsillitis or pharyngitis, and cervical adenitis. In this study we investigated DNA damage and the oxidative stress parameters in patients diagnosed with PFAPA, to elucidate the underlying pathophysiological mechanism of this syndrome. Methods: Thirty-one patients diagnosed with PFAPA (Group 1), 22 patients diagnosed with normal tonsillitis or pharyngitis (Group 2), and 20 healthy volunteers (Group 3) were included in our study. Heparinized peripheral blood samples were drawn from all patients and volunteers. DNA damage was assessed by single cell alkaline electrophoresis assay in peripheral mononuclear leukocytes. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using a novel automated measurement method, and oxidative stress index (OSI) was calculated. Results: DNA damage in the mononuclear leukocytes of Group 1 was significantly higher than that of Group 2 and Group 3. The oxidative stress parameters revealed that the TOS and OSI values of Group 1 were significantly higher than those of Group 2 and Group 3. TAS values of Group 1 were significantly lower than those of Group 2 and Group 3. Correlation analysis of Group 1 demonstrated a significant correlation between TOS, one of the oxidative stress parameters, and DNA damage. Correlations between DNA damage and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were also significant. Conclusion: Our study indicated that both the inflammatory and the oxidative stress parameters were significantly increased in patients with PFAPA syndrome, accompanied by a significant positive correlation between DNA damage and oxidative stress.
  • Thumbnail Image
    PublicationOpen Access
    Investigation of the role of major respiratory viruses in the aetiology of nasal polyps using polymerase chain reaction technique
    (2014-04-01) YENIGUN, A.; AKSOY, FEYZA MÜBERRA; DOGAN, REMZİ; Yilmaz, F.; Ozturan, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN; YENİGÜN, VILDAN BETÜL
    Objective: We aimed to identify the role of major respiratory viruses in the aetiology of human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with nasal polyps and a group of 20 healthy patients (control group) were included in this study. Mucosa was obtained from the polyps of patients with nasal polyposis and from the middle turbinate of the control group patients by means of biopsy. The samples were stored at -80 °C until molecular analysis by polymerase chain reaction was carried out. Results: In the control group, the human coronavirus and human rhinovirus were diagnosed in one of the patients and the human respiratory syncytial virus in another. In the group with nasal polyposis, the influenza B virus was identified in one of the patients and the human coronavirus in another. Conclusion: The results did not demonstrate a statistically significant relationship between nasal polyposis and respiratory viruses.
  • Thumbnail Image
    PublicationOpen Access
    An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats
    (2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUK
    Objectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.
  • Thumbnail Image
    PublicationOpen Access
    A new approach to vocal cord leukoplakia and evaluation of proton pump ınhibitor treatment.
    (2019-02-01) Ozturan, ORHAN; Sezen, Goktas; ÇALıM, ÖMER FARUK; YENIGUN, A; DOGAN, REMZİ; TUGRUL, SELHATTİN; DOĞAN, REMZI; YENİGÜN, ALPER; ÇALIM, ÖMER FARUK; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN
    Purpose: Our aim is identify a new approach to vocal cord leukoplakia treatment and detect to efficiency of proton pump inhibitors. Study design: Prospective, nonrandomized experimental clinical trial. Methods: A 'First Assessment Scale' was prepared. This scale included the lesion's and the patient's characteristics. Using this scale, 24 patients included to the study. 20 mg rabeprazole twice daily was applied to all patients. At the end of 3rd month, a 'Second Assessment Scale' was used and two groups created. In group 1, 19 patients were accepted to responsive for the therapy and received the same therapy. The group 2 was included five patients that accepted unresponsive to treatment and directed to surgery. All patients received the same treatment additionally 3 months. At the end of 6th month, the Reflux Symptom Index (RSI), the Reflux Finding Score (RFS) and the Red-Green-Blue (RGB) values evaluated and comparisons were made. Results: The RSI and RFS values were significantly decreased in all patients. The Red values were significantly decreased with treatment in group 1, but the Green and Blue values were not. In group 2, the RGB values were not showed the significant differences. In conclusion, seven patients (29,2%) showed complete lesion regression, 12 patients (50%) showed partial lesion regression and five patients (20,8%) showed no response to treatment. Conclusions: The proton pump inhibitor treatment may be beneficial for the selected patients. The scales that we prepared were useful for lesion assesment.
  • Thumbnail Image
    PublicationOpen Access
    Letter to the editor on -The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats-
    (2017-09-01) Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN
  • Thumbnail Image
    PublicationOpen Access
    Are There Any Systemic Effects of the Intratympanic Administration of Dexamethasone?
    (2018-07-01T00:00:00Z) Senturk, Erol; Tugrul, Selahattin; Yildirim, Yavuz Selim; DOĞAN, Remzi; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN; ŞENTÜRK, EROL; YILDIRIM, YAVUZ SELİM; DOĞAN, REMZI; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN
    Objective: Systemic absorption of steroids is reasonable because of the lipophilic nature of steroids and high vascularity of the middle ear mucosa. To date, however, of the clinical trials designed to investigate this subject, to the best of our knowledge, none has been based on objective methods. This study aims to demonstrate whether the intratympanic administration of dexamethasone has any systemic effects.