Person: ALİM TORAMAN, GÜLBAHAR ÖZGE
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Publication Metadata only Catechic Tannin Content of Different Tea Samples(2022-06-01T00:00:00Z) Alim Toraman, Gülbahar Özge; Tan, Nur; ALİM TORAMAN, GÜLBAHAR ÖZGEPublication Metadata only Di-, and Triterpenoids Isolation and LC-MS Analysis of Salvia marashica Extracts with Bioactivity Studies(2021-11-01T00:00:00Z) Toraman, Gulbahar O. Alim; Aydin, Sibel Kiran; Ertas, Abdulselam; Boga, Mehmet; EROL, EBRU; Saygi, Tuba Kusman; Halfon, Belkis; TOPÇU, GÜLAÇTI; EROL, EBRU; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIIn this study, dichloromethane, acetone, and methanol extracts of the aerial parts of the Salvia marashica plant which is an endemic species to Anatolia, were investigated. The total phenolic amounts of these extracts were determined as pyrocatechol equivalent and total flavonoids as quercetin equivalent. Antioxidant activity was determined by four complementary methods including inhibition of lipid peroxidation (by beta-carotene color expression), DPPH free radical scavenging activity, ABTS cation radical scavenging activity and CUPRAC methods. Anticholinesterase activity of the extracts was investigated by the Ellman method against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Viability and cytotoxic activity tests were carried out on the fibroblast L929 cells and cytotoxic A549 lung cancer cells, respectively. The triterpenoids and diterpenoids constitute the major secondary metabolites of the S. marashica acetone and methanol extracts isolated by chromatographic methods. Their structures were determined based on spectroscopic methods, namely NMR and mass analyses. Ten terpenoids were obtained from either acetone or methanol extracts of the S. marashica. Seven of them were triterpenoids, elucidated as lupeol, lupeol-3-acetate, lup-12, 20(29)-diene, lup-20(29)-ene, alpha-amyrin-tetracosanoate, oleanolic acid and ursolic acid besides a steroid beta-sitosterol. Two abietane diterpenes, abieta-8,11,13-triene (1) and 18-acetoxymethylene-abieta-8,11,13-triene (2), were obtained from the acetone extract which were isolated from a Salvia species for the first time in the present study. The methanol extract was found to be very rich in rosmarinic acid determined by LC-MS/MS analysis.Publication Metadata only Yeşil Alg Caulerpa cylindracea Sonder-den İzole Edilen Bis-İndol Alkaloidlerin SARS-CoV-2-ye Karşı in vitro Antiviral Aktivitesi(2022-06-23T00:00:00Z) Erol, Ebru; Avşar, Timuçin; Okudan, Emine Şükran; Topçu, Gülaçtı; EROL, EBRU; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTICaulerpaceae familyasına ait olanCaulerpa cylindraceaSonder yeşil bir deniz yosunudur. Gelibolu yarımadası kıyılarından SCUBA dalışlatoplananCaulerpacylindracea-nın builk kimyasal araştırması ile caulerpin1, mono metil caulerpinat2, beta-sitosterol ve palmitik asit izole edildi. İzole edilen bileşiklerin kimyasal yapıları, 1D- ve 2D-NMR ve kütle spektroskopik analizlerle aydınlatıldı. Caulerpin ve mono metil caulerpinatınin vitroanti-viral aktivitesi, Spike proteini ve main proteaza (3CL) karşı incelendi. Bu çalışmanın bulguları, caulerpin ve mono metil caulerpinatın Spike ve ACE2 etkileşimini önemli ölçüde inhibe ettiğini ortaya koymaktadır. Ayrıca, izole edilen bileşiklerin sitotoksik aktivitesi, sağlıklı fibroblast hücre hattı CCD-1079Sk ve iki meme kanseri hücre hattı; MDA-MB-231 ve MCF-7’ye karşı incelendi.Publication Metadata only Centaurea nemecii NAB. Ekstrelerinin Antikolinesteraz İnhibitör Aktivitesi(2021-12-08T00:00:00Z) Alim Toraman, Gülbahar Özge; Kuşman Sayğı, Tuba; Bütün, Burcu; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Metadata only Bazı Salvia Türleri Üzerinde Yapılan Klinik Araştırmalar(2021-11-19T00:00:00Z) Alim Toraman, Gülbahar Özge; Kuşman Sayğı, Tuba; Tan, Nur; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Metadata only GC-MS and LC-MS Analyses of a Brown Algae Cladostephus spongiosus Extracts with Bioactivity Studies(2021-12-08T00:00:00Z) Atasoy, Sezen; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; ATASOY, SEZEN; TOPÇU, GÜLAÇTIPublication Metadata only Aromaterapi(2021-01-01T00:00:00Z) TOPÇU, GÜLAÇTI; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI; ALİM TORAMAN, GÜLBAHAR ÖZGEPublication Metadata only Salvia sericeo-tomentosa var. sericeo-tomentosa ve Salvia sericeo-tomentosa var. hatayica taksonlarının polar ekstrelerinin kimyasal içeriği ve antidiyabetik aktivitelerinin belirlenmesi(2022-06-26T00:00:00Z) Alim Toraman, Gülbahar Özge; Tan, Nur; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Open Access Anti-SARS-CoV-2 and cytotoxic activity of two marine alkaloids from green alga Caulerpa cylindracea Sonder in the Dardanelles(2022-10-01T00:00:00Z) Erol, Ebru; Alim Toraman, Gulbahar Ozge; Orhan, Muge Didem; Avsar, Timucin; Akdemir, Atilla; Okudan, Emine Sukran; Topcu, Gulacti; EROL, EBRU; AKDEMİR, ATİLLA; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTICaulerpa cylindracea Sonder is a green alga belonging to the CauIerpaceae family. This is the first chemical investigation of C. cylindracea in the Dardanelles which resulted in the isolation of four compounds, caulerpin (1), monomethyl caulerpinate (2), beta-sitosterol (3), and palmitic acid (4). Their structures were elucidated by spectroscopic analyses including 1D- and 2D NMR and mass. The isolated compounds 1 and 2 were tested against the SARS-CoV-2 viral targets spike protein and main protease (3CL) enzyme, and both compounds significantly inhibit the interaction of spike protein and ACE2, while the main protease activity was not significantly reduced. Docking studies suggested that compounds 1 and 2 may bind to the ACE2 binding pocket on spike, and compound 2 may aka bind to an allosteric site on spike. As such, these compounds may inhibit the spike-ACE2 complex formation competitively and/or allosterically and have the potential to be used against SARS-CoV-2 virus infection. In addition, compounds 1 and 2 showed at [east two-fold higher cytotoxicity against breast cancer cell Lines MCF7 and MDA-MB-231 compared to the CCD fibroblast control cell LinePublication Metadata only Grateloupia turuturu ekstrelerinin anti-bakteriyel ve anti-fungal aktivitesi(2022-06-11T00:00:00Z) Zengin, Begüm; Dinç, Harika Öykü; Şenol, Halil; ALİM TORAMAN, GÜLBAHAR ÖZGE; DİNÇ, HARİKA ÖYKÜ; ŞENOL, HALIL