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ALİM TORAMAN, GÜLBAHAR ÖZGE

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GÜLBAHAR ÖZGE
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ALİM TORAMAN
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    Yeşil Alg Caulerpa cylindracea Sonder-den İzole Edilen Bis-İndol Alkaloidlerin SARS-CoV-2-ye Karşı in vitro Antiviral Aktivitesi
    (2022-06-23T00:00:00Z) Erol, Ebru; Avşar, Timuçin; Okudan, Emine Şükran; Topçu, Gülaçtı; EROL, EBRU; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
    Caulerpaceae familyasına ait olanCaulerpa cylindraceaSonder yeşil bir deniz yosunudur. Gelibolu yarımadası kıyılarından SCUBA dalışlatoplananCaulerpacylindracea-nın builk kimyasal araştırması ile caulerpin1, mono metil caulerpinat2, beta-sitosterol ve palmitik asit izole edildi. İzole edilen bileşiklerin kimyasal yapıları, 1D- ve 2D-NMR ve kütle spektroskopik analizlerle aydınlatıldı. Caulerpin ve mono metil caulerpinatınin vitroanti-viral aktivitesi, Spike proteini ve main proteaza (3CL) karşı incelendi. Bu çalışmanın bulguları, caulerpin ve mono metil caulerpinatın Spike ve ACE2 etkileşimini önemli ölçüde inhibe ettiğini ortaya koymaktadır. Ayrıca, izole edilen bileşiklerin sitotoksik aktivitesi, sağlıklı fibroblast hücre hattı CCD-1079Sk ve iki meme kanseri hücre hattı; MDA-MB-231 ve MCF-7’ye karşı incelendi.
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    Centaurea nemecii NAB. Ekstrelerinin Antikolinesteraz İnhibitör Aktivitesi
    (2021-12-08T00:00:00Z) Alim Toraman, Gülbahar Özge; Kuşman Sayğı, Tuba; Bütün, Burcu; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
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    Bazı Salvia Türleri Üzerinde Yapılan Klinik Araştırmalar
    (2021-11-19T00:00:00Z) Alim Toraman, Gülbahar Özge; Kuşman Sayğı, Tuba; Tan, Nur; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
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    GC-MS and LC-MS Analyses of a Brown Algae Cladostephus spongiosus Extracts with Bioactivity Studies
    (2021-12-08T00:00:00Z) Atasoy, Sezen; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; ATASOY, SEZEN; TOPÇU, GÜLAÇTI
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    Salvia sericeo-tomentosa var. sericeo-tomentosa ve Salvia sericeo-tomentosa var. hatayica taksonlarının polar ekstrelerinin kimyasal içeriği ve antidiyabetik aktivitelerinin belirlenmesi
    (2022-06-26T00:00:00Z) Alim Toraman, Gülbahar Özge; Tan, Nur; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
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    Adaçayı Yaprağı, Kara Şalba
    (2018-10-01) Tan, Nur; Yazıcı Tütüniş, Seçil; Yeşil, Yeter; Ekinci, Miraç; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
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    Natural Alkaloids as Potential Anti-Coronavirus Compounds
    (2020-12-01T00:00:00Z) Topçu, Gülaçtı; Şenol, Halil; Alim Toraman, Gülbahar Özge; Altan, Vecdi Melih; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; ALİM TORAMAN, GÜLBAHAR ÖZGE; ALTAN, VECDİ MELİH
    Coronaviruses are causative agents of the last three epidemics/pandemic; Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) and the last one Severe Acute Respiratory Syndrome-Cov-2 (SARS-CoV-2). Although meta-analysis of treatment studies against these three coronaviruses found no clear benefit of any spesific regimen, currently, remdesivir and favipiravir are promising potential therapies for SARS-CoV-2. On the other hand, since natural products have always played a crucial role in drug discovery and development process against various diseases, many groups in the world, are now trying to find new or repurposed natural or naturally originated drugs against viruses and coronaviruses. Secondary metabolites of the plants, particularly alkaloids and terpenoids have been exhibited strong antimicrobial and anticancer activities besides synthetic drugs and other natural compounds (nucleosides and nucleotides and bacterial and fungi originated ones). The first isolated secondary metabolites have been converted into important drugs since 1800’s such as morphine, codeine, cocaine, and quinine have alkaloid skeleton as well as some of the recent anticancer drugs vinblastine, vincristine, taxol, etc. This review includes the last two decades of publications about natural alkaloids rather than their plant extracts which showed some promising results against coronaviruses. Marine organisms are also another rich source to discover new lead drugs, however they were excluded in the present review article.